犏牛雄性不育的减数分裂基因表达与表观遗传调控研究进展

doi:10.16288/j.yczz.20-176

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Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (11): 1081-1092.doi: 10.16288/j.yczz.20-176

• Review • Previous Articles Next Articles

Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle

Huiyou Chen, Jianmin Zhang, Baisen Li, Yonglin Deng, Gongwei Zhang()

College of Animal Science and Technology , Southwest University, Chongqing 402460, China

Received:2020-06-15 Revised:2020-07-14 Online:2020-11-20 Published:2020-09-23
Contact: Zhang Gongwei E-mail:zgw-vip@163.com
Supported by:
Supported by the National Natural Science Foundation of China No(31802046);the Fundamental Research Funds for the Central Universities Nos(XDJK2020D011);the Fundamental Research Funds for the Central Universities Nos(XDJK2019RC001)

Abstract

Abstract:

Interspecific hybrid male sterility is a common occurrence in nature and plays an important role in species reproductive isolation. Dzo (cattle-yak), the offspring of interspecific cross between domestic yak (Bos grunniens) and cattle (Bos taurus), is a unique animal model for investigating interspecific hybrid male sterility. Dzo females are completely fertile while the males are sterile. In recent years, molecular studies have demonstrated that the expressions of genes were dysregulated during meiosis in Dzo testis, as compared to those in cattle or yak. Other studies have revealed that epigenetic factors/events, such as DNA methylation, histone modification and non-coding RNA, are also involved in spermatogenesis. This review summarizes the dysregulation of gene expression, DNA methylation, microRNA (miRNA), PIWI-interacting RNA (piRNA), long non-coding RNA (lncRNA), and histone methylation modification during meiosis in Dzo testis. These results highlighted the potential roles of genetic and epigenetic regulations of meiosis in Dzo testis, thereby providing a more detailed understanding on the molecular mechanisms of interspecific hybrid male sterility.

Key words: Dzo, male sterility, epigenetic, gene expression

Huiyou Chen, Jianmin Zhang, Baisen Li, Yonglin Deng, Gongwei Zhang. Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle[J]. Hereditas(Beijing), 2020, 42(11): 1081-1092.

Figures/Tables 3

Table 1

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基因	主要功能	参考文献
DAZ蛋白家族	DAZ、DAZL和BOULE蛋白是精子发生的重要调控因子	[6,26,27]
SYCP蛋白家族	SYCP1、SYCP2、SYCP3和FKBP6是联会复合体的重要组成部分,与精子发生过程中的减数分裂密切相关	[11~13,28,29]
DEAD-box蛋白家族	DDX4、DDX3Y和DDX25是生殖相关基因,参与广泛RNA代谢过程	[15,18,29]
减数分裂同源重组相关基因	DMC1、RAD51、RPA1和BLM是参与哺乳动物减数分裂同源重组修复的关键基因	[20,21]
MSY (Y染色体雄性特异区)相关基因	Y染色体连锁基因家族(TSPY、PRAMEY等)在精子发生和雄性生育中起重要作用	[25,30,31]
SNRPN	SNRPN (small nuclear ribonucleoprotein polypeptide N)与细胞分化和增殖有关	[32,33]
H19、IGF2	印迹基因IGF2 (insulin like growth factor 2)、H19 (H19 imprinted maternally expressed transcript)促进多种细胞的增殖、抑制细胞凋亡	[33,34]
CDC2、CDC25A	CDC2(cell division cycle 2)、CDC25A是减数分裂的两个关键基因	[35]
PIWIL1	PIWIL1(piwi like RNA-mediated gene silencing 1)在精子发生和转座子控制中起重要作用	[29,36]
STRA8	STRA8(stimulated by retinoic acid 8)参与调控精原干细胞(SSCs)自我更新与分化	[37]
PRDM9	PRDM9(PR/SET domain 9)具有PR结构域,和雄性不育相关	[38]
DMRT7	DMRT7(double sex and mab3-relatated transcrip-tion factor7)缺乏是犏牛雄性不育的一个强有力的候选因素	[39]
ERK1、ERK2	ERK1 (extracellular signal-regulated kinase 1)、ERK2属于MAPK信号通路	[40]

Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle

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