绵羊PRNP遗传多样性与抗病育种研究进展

doi:10.3724/SP.J.1005.2009.00137

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HEREDITAS ›› 2009, Vol. 31 ›› Issue (2): 137-141.doi: 10.3724/SP.J.1005.2009.00137

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Research progress on genetic diversity of sheep PRNP and resistance breeding

GUAN Feng¹,PAN Lei¹,SHI Guo-Qing²,LIU Shou-Ren²,YANG Li-Guo³

1. College of Life Sciences, China Jiliang University, Hangzhou 310018, China;
2. The Key Sheep Breeding and Reproduction Biotechnology Laboratory of Xinjiang Production and Construction Group, Shihezi 832000, China;
3. Key Laboratory of Agriculture Animal Heredity, Breeding and Reproduction, Ministry of Education, Huazhong Agriculture University, Wuhan 430070, China

Received:2008-05-04 Revised:2008-06-26 Online:2009-02-10 Published:2009-02-10
Contact: GUAN Feng1

Abstract

Abstract: Prion protein (PrP) is a pathogeny identified in recent years, which infects both mankind and other mammals. It has been proved that PrP is a sole protein able to duplicate and propagate with itself. PrP can express in many tissues and has important physiological functions in many species of animals. The conformation change of PrP is the origin of trans-missible spongiform encephalopathies (TSEs). It has been proved that the sheep genetic diversity of prion protein gene (PRNP) is significantly associated with the resistance to scrapie. In this review, the evidence of association between poly-morphisms of PRNP and resistance or susceptibility to scrapie and its effects on reproduction and performance traits were focused. The aim is to provide theory guidance for sheep breeding resistant to disease.

Key words: sheep, PRNP, genetic diversity, resistance, reproduction traits

GUAN Feng, PAN Lei, SHI Guo-Qing, LIU Shou-Ren, YANG Li-Guo. Research progress on genetic diversity of sheep PRNP and resistance breeding[J]. HEREDITAS, 2009, 31(2): 137-141.

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Research progress on genetic diversity of sheep PRNP and resistance breeding

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