植物RNA聚合酶IV调控DNA甲基化和发育的研究进展

doi:10.16288/j.yczz.22-063

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Hereditas(Beijing) ›› 2022, Vol. 44 ›› Issue (7): 567-580.doi: 10.16288/j.yczz.22-063

• Review • Previous Articles Next Articles

Advances of RNA polymerase IV in controlling DNA methylation and development in plants

Mengxuan Xu(), Ming Zhou()

Institute of Plant Biology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Received:2022-03-08 Revised:2022-06-07 Online:2022-07-20 Published:2022-06-21
Contact: Zhou Ming E-mail:21907017@zju.edu.cn;mingzhou@zju.edu.cn
Supported by:
Supported by 111 Project No(B14027);the Hundred-Talent Program of Zhejiang University

Abstract

Abstract:

DNA methylation is a type of stable epigenetic modifications that plays crucial roles in regulating gene expression, silencing transposons and maintaining genome stability. In plants, the de novo DNA methylation is established via a pathway termed as RNA-directed DNA methylation (RdDM). The plant-specific DNA-dependent RNA polymerase IV (Pol IV) as the core protein in RdDM pathway produces non-coding RNAs that direct the establishment of DNA methylation, regulates gene expression and controls plant development. Pol IV function is regulated by several proteins including SHH1, which recognizes H3K9 methylation and guides Pol IV to genome specific sites, the chromatin remodeling factor CLSY family that is involved in assisting Pol IV chromatin association and RDR2 that converts Pol IV produced single-stranded RNA into double-stranded RNA. In this review, we summarize the latest progress on Pol IV and its co-regulators, and focus on their functions in shaping epigenome and development in plants, which might provide implications for studying of DNA methylation and crop breeding.

Key words: DNA methylation, RdDM pathway, Pol IV, epigenome, development

Mengxuan Xu, Ming Zhou. Advances of RNA polymerase IV in controlling DNA methylation and development in plants[J]. Hereditas(Beijing), 2022, 44(7): 567-580.

Figures/Tables 3

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