遗传 ›› 2021, Vol. 43 ›› Issue (5): 393-396.doi: 10.16288/j.yczz.21-019

• 领域前瞻 • 上一篇    下一篇

解析基因组如何编码脑的挑战

谢维1,2,3(), 林承棋1, 李健1, 李默怡1,2   

  1. 1. 东南大学生命科学与技术学院,发育与疾病相关基因教育部重点实验室,南京 200096
    2. 东南大学医学院遗传与发育生物学系,南京 210009
    3. 东南大学脑科学与智能技术研究院/SEU-ALLEN联合中心,南京 200096
  • 收稿日期:2021-01-18 修回日期:2021-03-18 出版日期:2021-05-20 发布日期:2021-04-13
  • 通讯作者: 谢维 E-mail:wei.xie@seu.edu.cn
  • 基金资助:
    国家自然科学基金项目编号资助(91632201);国家自然科学基金项目编号资助(31430035)

Decoding brain encoded by genome

Wei Xie1,2,3(), Chengqi Lin1, Jian Li1, Moyi Li1,2   

  1. 1. The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China
    2. Department of Genetics and Development, School of Medicine, Southeast University, Nanjing 210009, China
    3. Institute for Brain and Intelligence, Southeast University, Nanjing 210096, China
  • Received:2021-01-18 Revised:2021-03-18 Online:2021-05-20 Published:2021-04-13
  • Contact: Xie Wei E-mail:wei.xie@seu.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China Nos(91632201);Supported by the National Natural Science Foundation of China Nos(31430035)

摘要:

人脑是自然界生物体内结构和功能最复杂的器官。解析人类基因组如何编码人脑的结构与功能是极具挑战的科学与技术问题,也是从根本上认识脑的本质问题。本文对近年来脑的“断面”组学研究的相关进展进行归纳,提出解析基因组如何编码脑的挑战与展望。

关键词: 脑, 发育, 基因组, 编码, 自闭症

Abstract:

Human brain is the most complicated living organ in nature. How the human genome encodes the structure and function of brain is a fundamental question to understand the essence of mind. Currently, it is still an unsolved scientific problem requiring the further breakthrough of comprehensive technologies. Here, we summarize the recent advances in brain development/function OMICS studies, and discuss the huge challenges and prospects in understanding how brain is encoded by genome.

Key words: brain, development, genome, encode, autism