遗传 ›› 2009, Vol. 31 ›› Issue (1): 13-28.doi: 10.3724/SP.J.1005.2009.00013

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哺乳动物性早熟相关基因的研究进展

储明星1;冯涛2;狄冉1;张宝云3;张英杰2

  

  1. 1. 中国农业科学院北京畜牧兽医研究所, 农业部畜禽遗传资源与利用重点开放实验室, 北京 100193;
    2. 甘肃农业大学动物科学技术学院, 兰州 730070;
    3. 重庆大学生物工程学院, 重庆 400030

  • 收稿日期:2008-04-23 修回日期:2008-05-19 出版日期:2009-01-10 发布日期:2009-01-10
  • 通讯作者: 储明星

Advances on related genes with sexual precocity in mammals

CHU Ming-Xing1;FENG Tao2;DI Ran1;ZHANG Bao-Yun3;ZHANG Ying-Jie2   

  1. 1. Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;
    3. Bioengineering College, Chongqing University, Chongqing 400030, China
  • Received:2008-04-23 Revised:2008-05-19 Online:2009-01-10 Published:2009-01-10
  • Contact: MingXing Chu

摘要:

人类的性早熟是一种病理状态, 而在动物上, 性早熟可能是一个在生产上具有价值的数量性状。一些物种在进化过程中形成了性早熟的特性并能在群体中稳定遗传。性早熟在很大程度上与遗传密切相关, 是一个由多基因决定的复杂性状。文章主要介绍了KiSS-1基因、GPR54基因、LHR基因、FSHR基因、CYP基因家族、ER基因、TGFa基因、IGF-Ⅰ基因、GNAS1基因、HSD3B2基因、SHBG基因、VDR基因等与哺乳动物性早熟的关系。

关键词: 性早熟, 初情期, 基因, 生殖, 调控

Abstract:

In mammals and humans, reproductive capacity is attained at puberty as the end-point of a complex series of developmental and neuroendocrine events that lead to true sexual maturity. As for humans, sexual precocity looks like a pathologic status. While for some animals, sexual precocity may be a valuable quantitative character. For some species, the character of sexual precocity was developed in the evolutionary process and stably transmitted to future generations. Sexual precocity is a complex character determined by polygenes. This review introduced the association between KiSS-1, GPR54, LHR, FSHR, CYP, ER, TGFa, IGF-Ⅰ, GNAS1, HSD3B2, SHBG, VDR genes and sexual precocity in mammals.