遗传 ›› 2012, Vol. 34 ›› Issue (1): 19-26.doi: 10.3724/SP.J.1005.2012.00019

• 综述 • 上一篇    下一篇

鸡的端粒生物学研究

王伟, 王珊珊, 李辉, 王宁   

  1. 东北农业大学动物科学与技术学院, 哈尔滨 150030
  • 收稿日期:2011-04-13 修回日期:2011-06-28 出版日期:2012-01-20 发布日期:2012-01-25
  • 通讯作者: 王宁 E-mail:ningwang2001@yahoo.com
  • 基金资助:

    国家自然科学基金项目(编号:30972086)和国家重点基础研究发展计划(973计划)项目(编号:2009CB941604)资助

Telomere biology of the chicken

WANG Wei, WANG Shan-Shan, LI Hui, WANG Ning   

  1. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China
  • Received:2011-04-13 Revised:2011-06-28 Online:2012-01-20 Published:2012-01-25
  • Contact: Ning WANG E-mail:ningwang2001@yahoo.com

摘要: 端粒是线性染色体末端的核蛋白“帽子”结构, 其长度由端粒酶来维持。端粒对于维持基因组的稳定、防止细胞衰老和肿瘤发生具有重要的作用。鸡是遗传和发育研究的经典模式动物, 随着鸡基因组学研究的不断深入, 鸡的端粒和端粒酶研究取得了很大进展。文章综述了近年来鸡的端粒生物学研究进展, 并提出了未来的研究方向。

关键词: 鸡端粒酶RNA, 鸡, 端粒, 端粒酶, 鸡端粒酶逆转录酶

Abstract: Telomeres, the nucleoprotein “caps” protecting the ends of linear chromosomes, are maintained by telomerase. Telomeres have important roles in maintaining genomic stability and preventing senescence or oncogenesis. Chicken is a classical model animal for genetic and developmental studies. With further development of chicken genomics, great progress has been made in research of chicken telomere and telomerase. This review describes recent advances and future research directions in chicken telomere biology.

Key words: chicken, telomere, telomerase, chTERT, chTR