遗传 ›› 2014, Vol. 36 ›› Issue (5): 447-455.doi: 10.3724/SP.J.1005.2014.0447

• 综述 • 上一篇    下一篇

细胞自噬发生的表观遗传调节

孙源超1,2, 秦训思1, 陈宏2, 沈伟1   

  1. 1. 青岛农业大学动物科技学院, 山东省高校动物生殖与种质创新重点实验室, 青岛 266109; 
    2. 西北农林科技大学动物科技学院, 陕西省农业分子生物学重点实验室, 杨凌 712100
  • 收稿日期:2013-10-22 修回日期:2014-01-16 出版日期:2014-05-20 发布日期:2014-05-25
  • 通讯作者: 沈伟, 博士, 教授, 博士生导师, 研究方向:生殖细胞生物学。E-mail: shenwei427@163.com E-mail:shenwei427@163.com
  • 作者简介:孙源超, 博士研究生, 研究方向:生殖细胞生物学。E-mail: sycdeyx1@163.com
  • 基金资助:

    教育部新世纪优秀人才支持计划(编号:NCET-12-1026)和山东省自然科学杰出青年基金项目(编号:JQ201109)资助

Epigenetic control of autophagy

Yuanchao Sun1,2 , Xunsi Qin1, Hong Chen2, Wei Shen1   

  1. 1. Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China; 
    2. Key Laboratory of Agricultural Molecular Biology of Shanxi, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
  • Received:2013-10-22 Revised:2014-01-16 Online:2014-05-20 Published:2014-05-25

摘要:

细胞自噬是一种进化上保守的, 通过吞噬降解自身大分子物质或细胞器来维持细胞生存的活动。自噬与多种生命活动息息相关, 其功能的紊乱往往会导致肿瘤发生、神经退行性疾病、微生物感染等疾病。研究表明, 表观遗传修饰可以调控细胞自噬的发生, 并在细胞自噬的生物学功能调节过程中发挥重要作用, 但具体调控机制尚需进一步探究。文章综述了细胞自噬发生过程中存在的表观遗传效应, 包括组蛋白乙酰化对细胞自噬激活或抑制的负反馈调控, 通过DNA甲基化调节自噬相关基因活性来影响细胞自噬的发生, miRNA通过靶向调节自噬相关基因表达来影响组蛋白修饰, 从而调控细胞自噬的发生及作用过程等, 旨在为人们进一步研究细胞自噬发生过程中的表观遗传修饰及其机制提供信息依据。

关键词: 自噬, 表观遗传, DNA甲基化, 组蛋白修饰, miRNA

Abstract:

Autophagy is an evolutionarily conserved cellular process through cell degradation of own protein aggregates or organelles to survive. Autophagy is closely related to many life activities, and especially, its dysfunctions might cause many diseases and physiological problems, such as tumorigenesis, neurodegeneration and microbial infection. In recent years, many studies found that epigenetic modifications may regulate the occurrence of autophagy and also play an important role in the process of autophgy biological function.However the exact mechanism of epigenetic modifications remains largely unknown. Here,we review the epigenetic effects on regulation of autophagy process, including histone acetylation activation and negatively feedback controlling autophagy, DNA methylation regulating cell autophagy process by changing autophagy related genes, and miRNA regulating autophagy related gene expression by targeted degradation and histone modifications. This review will help understand the relationship between epigenetic effects and autophagy.

Key words: autophagy, epigenetic effects, DNA methylation, histone modification, miRNA