摘要： 为调查广东地区汉族人群中是否存在着亚群结构，对来自广州、佛山、东莞、江门和中山-珠海5个不同地区的471随机个体血样本进行15个STR的基因分型，并作Hardy-Weinberg平衡检验，比较群体之间的等位基因频率，计算这个5个地区人群间的共祖系数。结果显示，广东汉族人群没有明显的Hardy-Weinberg不平衡，5个地区人群的等位基因分布均没有差异，他们之间的共祖系数小于0.01。因此，广东地区汉族人群中没有明显的亚群结构。
Abstract:To investigate the subpopulation structure within the Han Population in Guandong area,a total of 471 DNA samples from five populations in Guandong Province,including Guangzhou,Foshan,Dongguan,Jiangmen and Zhongshan-Zhuhai region,were genotyped at 15 STR(short tandem repeats) markers.Hardy-Weinberg tests were performed,allele frequencies were compared,and the genetic coancestry coefficient(FST ) was estimated.The results did not show significant departure from Hardy-Weinberg equilibrium in the total population.Difference of allele frequencies among these populations was not observed,and the coancestry coefficient(FST)was less than 0.01.Subpopulation structure within Han Population in Guandong Province could not be detected.