羊慢病毒及其抗性基因研究进展

doi:10.3724/SP.J.1005.2014.1204

遗传 ›› 2014, Vol. 36 ›› Issue (12): 1204-1210.doi: 10.3724/SP.J.1005.2014.1204

羊慢病毒及其抗性基因研究进展

管峰¹, 石国庆², 赵进¹, 王一民³

1. 中国计量学院生命科学学院, 杭州 310018;
2. 新疆兵团绵羊繁育生物技术重点实验室, 石河子 832000;
3. 杭州彩洋牧业有限公司, 杭州 310000

收稿日期:2014-05-09 出版日期:2014-12-20 发布日期:2014-12-20
作者简介:管峰, 博士, 副教授, 研究方向：动物分子遗传育种。
基金资助:
国家自然科学基金项目(编号：31360540), 国家高技术研究发展计划(863计划)项目(编号：2011AA100307)和十二五国家支撑计划课题(编号：2011BAD28B05-1-1)资助

Progress on ovine lentivirus and its resistant genes

Feng Guan¹, Guoqing Shi², Jin Zhao¹, Yimin Wang³

1. College of Life Sciences, China Jiliang University, Hangzhou 310018, China;
2. The Key Sheep Breeding and Reproduction Biotechnology Laboratory of Xinjiang Production and Construction Group, Shihezi 832000, China;
3. Hangzhou Caiyang Animal Husbandry Co., Ltd. Hangzhou 310000, China

Received:2014-05-09 Online:2014-12-20 Published:2014-12-20

摘要/Abstract

摘要： 羊慢病毒也称小反刍动物慢病毒, 主要包括绵羊梅迪–维斯纳病毒和山羊关节炎–脑炎病毒, 二者主要感染绵羊和山羊, 目前该病在世界范围内流行并给养羊业带来很大的经济损失。研究表明, 不同绵羊品种对慢病毒易感性存在差异, 这种差异表明易感性不同的绵羊可能存在遗传多样性的差异。全基因组关联分析发现绵羊跨膜蛋白TMEM154 (Transmembrane protein 154)基因中的一个点突变E35K与抗病力高度相关, 可以作为绵羊抗病选育的分子标记。文章详述了绵羊TMEM154基因E35K突变对抗病力的影响和当前慢病毒抗病基因研究概况, 包括锌指家族、趋化因子受体CCR5、三重基序蛋白TRIM5α、载脂蛋白B mRNA剪辑酶催化多肽样蛋白3、多能发育相关基因2和4, 并简要介绍了羊慢病毒特征和我国羊慢病毒病的流行状况, 以期为我国绵羊养殖业和抗病选育提供参考。

关键词: 羊慢病毒, 梅迪–维斯纳病毒(MVV), TMEM154基因, 突变, 抗病性

Abstract: Ovine lentivirus, also termed as small ruminant lentiviruses (SRLVs), includesmaedi-visna virus (MVV) and caprine arthritis encephalitis virus (CAEV), which can infect sheep and goats. SRLVs are wide spread throughout the world causing serious economic implications for animal industry. Breed differences in susceptibility to MVV had suggested a strong genetic diversity in sheep. Genome wide association study (GWAS) indicated that a SNP (E35K) in ovine transmemebrane protein 154 (TMEM154) gene was significantly associated with sheep resistance to MVV and can be used as a molecular marker in sheep resistant selection breeding. Here, we review the progress of E35K mutation in sheep TMEM154 gene and its effects on resistance to MVV, and other lentivirusresistant genes including zinc finger cluster, chemokine reveptor 5 (CCR5), tripartite motif-containing 5 alpha (TRIM5α), apolipoprotein B mRNA-editing catalytic polypetide like 3 (APOBEC3), developmental pluripotencyassociated 2 (DPPA2) and DPPA4. Furthermore, SRLVs and the epidemic status are introduced. We hope to provide some guidance for sheep re-sistant breeding.

Key words: ovine lentivirus, maedi-visna virus, TMEM154 gene, mutation, resistance

管峰, 石国庆, 赵进, 王一民. 羊慢病毒及其抗性基因研究进展[J]. 遗传, 2014, 36(12): 1204-1210.

Feng Guan, Guoqing Shi, Jin Zhao, Yimin Wang. Progress on ovine lentivirus and its resistant genes[J]. HEREDITAS(Beijing), 2014, 36(12): 1204-1210.

参考文献

[1] Ramírez H, Reina R, Amorena B, de Andrés D, Martínez HA. Small ruminant lentiviruses: genetic variability, tropism and diagnosis. Viruses, 2013, 5(4): 1175–1207.
[2] Larruskain A, Jugo BM. Retroviral infections in sheep and goats: small ruminant lentiviruses and host interaction. Viruses, 2013, 5(8): 2043–2061.
[3] 曲娟娟, 刘慧敏, 相文华, 沈荣显. 山羊关节炎–脑炎的研究现状. 中国预防兽医学报, 2005, 27(4): 431–434.
[4] Blacklaws BA. Small ruminant lentiviruses: immuno-pathogenesis of visna-maedi and caprine arthritis and en-cephalitis virus. Comp Immunol Microbiol Infect Dis, 2012, 35(3): 259–269.
[5] Shah C, Huder JB, B?ni J, Sch?nmann M, Mühlherr J, Lutz H, Schüpbach J. Direct evidence for natural transmission of small-ruminant lentiviruses of subtype A4 from goats to sheep and vice versa. J Virol, 2004, 78(14): 7518–7522.
[6] Minardi da Cruz JC, Singh DK, Lamara A, Chebloune Y. Small ruminant lentiviruses (SRLVs) break the species barrier to acquire new host range. Viruses, 2013, 5(7): 1867–1884.
[7] Smith JB, Jenks JA, Grovenburg TW, Klaver RW. Disease and Predation: Sorting out Causes of a Bighorn Sheep (Ovis canadensis) Decline. PLoS ONE, 2014, 9(2): e88271.
[8] White SN, Knowles DP. Expanding possibilities for inter-vention against small ruminant lentiviruses through genetic marker-assisted selective breeding. Viruses, 2013, 5(6): 1466–1499.
[9] Leymaster KA, Chitko-McKown CG, Clawson ML, Harhay GP, Heaton MP. Effects of TMEM154 haplotypes 1 and 3 on susceptibility to ovine progressive pneumonia virus following natural exposure in sheep. J Anim Sci, 2013, 91(11): 5114–5121.
[10] Leroux C, Cruz JC, Mornex JF. SRLVs: a genetic continuum of lentiviral species in sheep and goats with cumulative evidence of cross species transmission. Curr HIV Res, 2010, 8(1): 94–100.
[11] White SN, Mousel MR, Reynolds JO, Herrmann-Hoesing LM, Knowles DP. Deletion variant near ZNF389 is asso-ciated with control of ovine lentivirus in multiple sheep flocks. Anim Genet, 2014, 45(2): 297–300.
[12] Thormar H. The origin of lentivirus research: Maedi-visna virus. Curr HIV Res, 2013, 11(1): 2–9.
[13] Sider LH, Heaton MP, Chitko-McKown CG, Harhay GP, Smith TP, Leymaster KA, Laegreid WW, Clawson ML. Small ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes. Vet Res, 2013, 44: 64.
[14] Crawford TB, Adams DS, Cheevers WP, Cork LC. Chronic arthritis in goats caused by a retrovirus. Science, 1980, 207(4434): 997–999.
[15] Li Y, Zhou FJ, Li X, Wang JH, Zhao XP, Huang JH. De-velopment of TaqMan-based qPCR method for detection of caprine arthritis-encephalitis virus (CAEV) infection. Arch Virol, 2013, 158(10): 2135–2141.
[16] 夏炉明, 陈琦, 孙泉云. 梅迪–维斯纳病概述. 上海畜牧兽医通讯, 2011, (4): 56–57.
[17] Heaton MP, Clawson ML, Chitko-Mckown CG, Leymaster KA, Smith TPL, Harhay GP, White SN, Herrmann-Hoesing LM, Mousel MR, Lewis GS, Kalbfleisch TS, Keen JE, Laegreid WW. Reduced lentivirus susceptibility in sheep with TMEM154 mutations. PLoS Genet, 2012, 8(1): e1002467.
[18] Keen JE, Hungerford LL, Littledike ET, Wittum TE, Kwang J. Effect of ewe ovine lentivirus infection on ewe and lamb productivity. Prev Vet Med, 1997, 30(2): 155–169.
[19] White SN, Mousel MR, Herrmann-Hoesing LM, Reynolds JO, Leymaster KA, Neibergs HL, Lewis GS, Knowles DP. Genome-wide association identifies multiple genomic re-gions associated with susceptibility to and control of ovine lentivirus. PLoS ONE, 2012, 7(10): e47829.
[20] Benavides J, Fuertes M, García-Pariente C, Otaola J, Del-gado L, Giraldez J, García Marín JF, Carmen Ferreras M, Pérez V. Impact of maedi-visna in intensively managed dairy sheep. Vet J, 2013, 197(3): 607–612.
[21] Sigurdsson B, Grimsson H, Palsson PA. Maedi, a chronic, progressive infection of sheep's lungs. J Infect Dis, 1952, 90(3): 233–241.
[22] 邓普辉, 简子健, 刘君明, 阿合买提?买买提, 周自富, 朱飞兵. 绵羊进行性肺炎在世界的流行及控制. 新疆农业科学, 1992, (4): 189–192.
[23] Gudnadóttir M, Demosthe

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

羊慢病毒及其抗性基因研究进展

Progress on ovine lentivirus and its resistant genes

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	李凯伦, 卢荆奥, 陈小辉, 张文清, 刘伟. 尿囊素促进破骨细胞缺陷斑马鱼骨折修复[J]. 遗传, 2023, 45(4): 341-353.
[2]	龚一鸣, 王翔宇, 贺小云, 刘玉芳, 余平, 储明星, 狄冉. 绵羊FecB突变对BMPR1B活性及BMP/SMAD通路的影响研究进展[J]. 遗传, 2023, 45(4): 295-305.
[3]	马捷, 黄露杰, 张巧霞, 朱艳, 钱露. 以A2型短指(趾)症为案例的医学遗传学PBL教学设计[J]. 遗传, 2023, 45(2): 176-183.
[4]	李璐阳, 刘孙强, 施云, 赵成程, 周红文, 郑旭琴. 一例葡萄糖激酶基因突变致低血糖症的诊疗及家系遗传分析[J]. 遗传, 2022, 44(9): 810-818.
[5]	张充, 魏子璇, 王敏, 陈瑶生, 何祖勇. 利用CRISPR/Cas9在人类黑色素瘤细胞中编辑MC1R与功能分析[J]. 遗传, 2022, 44(7): 581-590.
[6]	宋绍征, 何正义, 成勇, 于宝利, 张婷, 李丹. TALENs介导MSTN基因突变山羊的制备及性能分析[J]. 遗传, 2022, 44(6): 531-542.
[7]	王思琪, 陈阳, 罗宽宏, 史宁杰, 肖康丽, 崔振海, 曾天舒, 黎慧清. 一例SOX10基因缺失所致的Waardenburg综合征2型合并低促性腺激素性性腺功能减退症的诊断和基因检测分析[J]. 遗传, 2022, 44(12): 1158-1166.
[8]	宋青青, 张素素, 张振, 孙嘉, 杨锐, 李佶桐, 陈宏. 一例CYP11B基因突变导致11β-羟化酶缺乏症的诊疗和基因检测分析[J]. 遗传, 2022, 44(12): 1175-1182.
[9]	贾觉睿智, 肖诚, 刘艺文, 李冉, 张化冰, 于淼. 二例GCK基因突变致先天性高胰岛素性低血糖症的诊疗和基因检测分析[J]. 遗传, 2022, 44(11): 1056-1062.
[10]	肖诚, 刘洁颖, 杨春如, 于淼. LMNA基因突变相关脂肪萎缩综合征的研究进展[J]. 遗传, 2022, 44(10): 913-925.
[11]	蒋琬姿, 张丽雯, 贺彩红, 阮梅花, 季勇, 于建荣, 周红文. 家族性高胆固醇血症研究进展[J]. 遗传, 2021, 43(11): 1011-1022.
[12]	刘志勇, 任贺, 陈冲, 张京晶, 张晓梦, 石妍, 石林玉, 陈滢, 程凤, 贾莉, 陈曼, 范庆炜, 张家榕, 李万婷, 王萌春, 任子林, 刘雅诚, 倪铭, 孙宏钰, 严江伟. 基于有限突变模型和大规模数据的19个常染色体STR的实际突变率研究[J]. 遗传, 2021, 43(10): 949-961.
[13]	赵利楠, 王娜, 杨国良, 苏现斌, 韩泽广. 基于单细胞靶向测序探究基因碱基突变的方法[J]. 遗传, 2020, 42(7): 703-712.
[14]	程苗苗, 曹延延. NMD逃逸机制及其在疾病治疗中的应用[J]. 遗传, 2020, 42(4): 354-362.
[15]	朱海美, 黄鹏程, 赵田田, 周长慧, 李若婉, 于春荣, 陈志勇, 顾林峰, 常艳. 纳米银颗粒及纳米二氧化钛颗粒的体外遗传毒性研究[J]. 遗传, 2020, 42(12): 1192-1200.