遗传 ›› 2018, Vol. 40 ›› Issue (1): 22-32.doi: 10.16288/j.yczz.17-163

• 综述 • 上一篇    下一篇

GATA6在肝脏发育中的作用及调控机制

张玲(),何建波   

  1. 西南大学生命科学学院,淡水鱼类资源与生殖发育教育部重点实验室,重庆 400715
  • 收稿日期:2017-05-08 修回日期:2017-12-13 出版日期:2018-01-20 发布日期:2017-12-27
  • 基金资助:
    国家级大学生创新创业训练计划(201610635068);中央高校基本科研业务费专项资金(XDJK2015B011)

Progress of GATA6 in liver development

Ling Zhang(),Jianbo He   

  1. Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400715, China
  • Received:2017-05-08 Revised:2017-12-13 Online:2018-01-20 Published:2017-12-27
  • Supported by:
    the National Undergraduate Innovation and Entrepreneurship Training Program of China(201610635068);Fundamental Research Funds for the Central Universities(XDJK2015B011)

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摘要：

GATA6 (GATA binding protein 6)是GATA锌指转录因子家族成员之一,以其保守的结合基序(G/A)GATA(A/T) 而得名。GATA家族在脊椎动物细胞命运决定与分化、增殖和迁移以及内胚层和中胚层来源的器官发育中具有重要作用。GATA6作为谱系特化因子、染色质重塑因子、多能性因子和“先锋因子”,在内胚层肝脏谱系决定、肝脏特化、肝芽生长以及肝母细胞增殖分化等阶段发挥关键的调控作用。本文综述了GATA6在肝脏发育中的作用及其研究进展,以期为进一步研究 GATA6 等发育关键转录因子的功能及调控机制提供参考。

关键词: GATA6, 肝脏发育, 转录因子, 先锋因子, 重编程

Abstract:

GATA binding protein 6 (GATA6) is a member of the GATA family of zinc-finger transcriptional regulators, whose names come from the conservative base sequence (G/A)GATA(A/T). The GATA families play key roles in cell fate determination, proliferation, migration, and organogenesis of endoderm- and mesoderm-derived organs in vertebrates. As a lineage-specific factor, a chromatin remodeling factor, a pluripotent factor and a pioneer factor, GATA6 is involved in various stages of liver development, including endoderm liver-lineage determination, liver specification, hepatic bud outgrowth and hepatoblast differentiation. In this review, we summarize recent progress in the roles and regulatory mechanisms of GATA6 in liver development.

Key words: GATA6, liver development, transcription factor, pioneer factor, reprogramming