遗传 ›› 2021, Vol. 43 ›› Issue (3): 215-225.doi: 10.16288/j.yczz.20-332

• 综述 • 上一篇    下一篇

RHR转录因子家族起源、功能以及进化机制的研究进展

吕孟冈1,2(), 刘艾嘉1,2, 李庆伟1,2(), 苏鹏1,2()   

  1. 1 辽宁师范大学生命科学学院,大连 116081
    2 辽宁师范大学七鳃鳗研究中心,大连 116081;
  • 收稿日期:2020-11-25 发布日期:2021-01-29
  • 基金资助:
    国家自然科学基金项目(31801973);国家自然科学基金项目(31772884);,大连市支持高层次人才创新创业项目(2019RQ126);国家重大基础研究发展规划(973)计划课题(2013CB835304);全国海洋公益项目(201305016);,辽宁省海洋与渔业厅科研项目(201805);大连市科技创新基金项目(2018J12SN079)

Progress on the origin, function and evolutionary mechanism of RHR transcription factor family

Menggang Lv1,2(), Aijia Liu1,2, Qingwei Li1,2(), Peng Su1,2()   

  1. 1 College of Life Science, Liaoning Normal University, Dalian 116081, China
    2 Lamprey Research Center, Liaoning Normal University, Dalian 116081, China;
  • Received:2020-11-25 Published:2021-01-29
  • Supported by:
    the National Natural Science Foundation of China(31801973);the National Natural Science Foundation of China(31772884);Dalian Supports Innovation and Entrepreneurship Projects of High Level Talents(2019RQ126);the Chinese Major State Basic Research Development Program (973)(2013CB835304);the Marine Public Welfare Project of the State Oceanic Administration(201305016);the project of Department of Ocean and Fisheries of Liaoning Province(201805);and the Science and Technology Innovation Fund Research Project(2018J12SN079)

摘要:

转录因子是一类能够通过与基因特异性序列进行结合,从而调控基因转录与表达的蛋白质,对细胞的生物学活性具有重要的调节作用。RHR (Rel-homology region, RHR)转录因子家族属于IF (immunoglobulin fold)转录因子超家族最主要的成员,其成员含有保守的Rel结构域和IPT (immunoglobulin-like fold)结构域。作为古老的转录因子家族,RHR家族成员随着物种演化,通过基因的复制、突变和沉默,不断分化出新型同源基因的同时也伴随着基因的丢失。自然选择导致了各家族成员不同的进化速率,并且在一些功能结构域上展现出了特殊的进化机制。然而,目前有关RHR家族起源和分化的综述比较少见。本文综述了RHR家族各成员的分布、分类、功能及家族进化等方面的研究成果,以期为研究整个转录因子家族的演化机制和物种之间的进化关系提供参考和新的思路。

关键词: 转录因子, RHR家族, 进化, 基因复制, 同源基因

Abstract:

Transcription factors are a class of proteins that regulate gene transcription and expression by binding to gene-specific sequences and play an essential role in regulating the biological activities of cells. The RHR (Rel-homology region) transcription factor family is the primary member of the IF (immunoglobulin fold) transcription factor superfamily, whose members contain the conserved Rel domain and IPT (immunoglobulin-like fold) domain. As an ancient transcription factor family, the RHR family continues differentiation on gene gain and loss through gene duplication, mutation, and silencing, accompanied with the evolution of diverse species. Natural selection has led to different rates of evolution among members of the family, and some domains of the protein family have shown unique mechanisms of evolution. However, the current reviews about the origin and differentiation of RHR family are rare. In this review, we summarize the research results on the distribution, classification, function, and evolution of the members of the RHR family in order to provide a reference and new idea for studying the evolution mechanism of the whole transcription factor family and the evolutionary relationship among species.

Key words: transcription factors, RHR family, evolution, gene duplication, homologous gene