| [1] Sauve AA, Wolberger C, Schramm VL, Boeke JD. The biochemistry of sirtuins. Annu Rev Biochem, 2006, 75(1): 435–465.
[2] Haigis MC, Guarente LP. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev, 2006, 20(21): 2913–2921.
[3] Michan S, Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem J, 2007, 404(1): 1–13.
[4] Nemoto S, Fergusson MM, Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science, 2004, 306(5704): 2105–2108.
[5] Ford J, Jiang M, Milner J. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res, 2005, 65(22): 10457–10463.
[6] Brooks CL, Gu W. How does SIRT1 affect metabolism, se-nescence and cancer? Nat Rev Cancer, 2009, 9(2): 123–128.
[7] Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guar-ente L, Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell, 2001, 107(2): 137–148.
[8] Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. hSIR2(SIRT1) functions as an NAD+-dependent p53 deacetylase. Cell, 2001, 107(2): 149–159.
[9] Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L. SIRT1 represses fork-head transcription factors. Cell, 2004, 116(4): 551–563.
[10] Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Stress-dependent regulation of FOXO tran-scription factors by the SIRT1 deacetylase. Science, 2004, 303(5666): 2011–2015.
[11] Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, Watkins DN, Herman JG, Mankowski JL, Baylin SB. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet, 2003, 33(2): 197–202.
[12] Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB. Tu-mor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell, 2005, 123(3): 437–448.
[13] Zhang Q, Wang SY, Fleuriel C, Leprince D, Rocheleau JV, Piston DW, Goodman RH. Metabolic regulation of SIRT1 transcription via a HIC1: CtBP corepressor complex. Proc Natl Acad Sci USA, 2007, 104(3): 829–833.
[14] Chen W, Cooper TK, Zahnow CA, Overholtzer M, Zhao Z, Ladanyi M, Karp JE, Gokgoz N, Wunder JS, Andrulis IL, LJvine AF, Mankowski JL, Baylin SB. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumori-genesis. Cancer Cell, 2004, 6(4): 387–398.
[15] Stankovic-Valentin N, Deltour S, Seeler J, Pinte S, Vergoten G, Guerardel C, Dejean A, Leprince D. An acetyla-tion/deacetylation-SUMOylation switch through a phyloge-netically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol Cell Biol, 2007, 27(7): 2661–2675.
[16] Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J, 2000, 19(4): 662–671.
[17] Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S, Finkel T, Gu W, Cress WD, Chen J. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol, 2006, 8(9): 1025–1031.
[18] Kwon HS, Ott M. The ups and downs of SIRT1. Trends Bio-chem Sci, 2008, 33(11): 517–525.
[19] Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell, 2007, 25(4): 543–557.
[20] Yamakuchi M, Ferlito M, Lowenstein CJ. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci USA, 2008, 105 |
