遗传 ›› 2014, Vol. 36 ›› Issue (12): 1204-1210.doi: 10.3724/SP.J.1005.2014.1204

• 综述 • 上一篇    下一篇

羊慢病毒及其抗性基因研究进展

管峰1, 石国庆2, 赵进1, 王一民3   

  1. 1. 中国计量学院生命科学学院, 杭州 310018;
    2. 新疆兵团绵羊繁育生物技术重点实验室, 石河子 832000;
    3. 杭州彩洋牧业有限公司, 杭州 310000
  • 收稿日期:2014-05-09 出版日期:2014-12-20 发布日期:2014-12-20
  • 作者简介:管峰, 博士, 副教授, 研究方向:动物分子遗传育种。
  • 基金资助:
    国家自然科学基金项目(编号:31360540), 国家高技术研究发展计划(863计划)项目(编号:2011AA100307)和十二五国家支撑计划课题(编号:2011BAD28B05-1-1)资助

Progress on ovine lentivirus and its resistant genes

Feng Guan1, Guoqing Shi2, Jin Zhao1, Yimin Wang3   

  1. 1. College of Life Sciences, China Jiliang University, Hangzhou 310018, China;
    2. The Key Sheep Breeding and Reproduction Biotechnology Laboratory of Xinjiang Production and Construction Group, Shihezi 832000, China;
    3. Hangzhou Caiyang Animal Husbandry Co., Ltd. Hangzhou 310000, China
  • Received:2014-05-09 Online:2014-12-20 Published:2014-12-20

摘要: 羊慢病毒也称小反刍动物慢病毒, 主要包括绵羊梅迪–维斯纳病毒和山羊关节炎–脑炎病毒, 二者主要感染绵羊和山羊, 目前该病在世界范围内流行并给养羊业带来很大的经济损失。研究表明, 不同绵羊品种对慢病毒易感性存在差异, 这种差异表明易感性不同的绵羊可能存在遗传多样性的差异。全基因组关联分析发现绵羊跨膜蛋白TMEM154 (Transmembrane protein 154)基因中的一个点突变E35K与抗病力高度相关, 可以作为绵羊抗病选育的分子标记。文章详述了绵羊TMEM154基因E35K突变对抗病力的影响和当前慢病毒抗病基因研究概况, 包括锌指家族、趋化因子受体CCR5、三重基序蛋白TRIM5α、载脂蛋白B mRNA剪辑酶催化多肽样蛋白3、多能发育相关基因2和4, 并简要介绍了羊慢病毒特征和我国羊慢病毒病的流行状况, 以期为我国绵羊养殖业和抗病选育提供参考。

关键词: 羊慢病毒, 梅迪–维斯纳病毒(MVV), TMEM154基因, 突变, 抗病性

Abstract: Ovine lentivirus, also termed as small ruminant lentiviruses (SRLVs), includesmaedi-visna virus (MVV) and caprine arthritis encephalitis virus (CAEV), which can infect sheep and goats. SRLVs are wide spread throughout the world causing serious economic implications for animal industry. Breed differences in susceptibility to MVV had suggested a strong genetic diversity in sheep. Genome wide association study (GWAS) indicated that a SNP (E35K) in ovine transmemebrane protein 154 (TMEM154) gene was significantly associated with sheep resistance to MVV and can be used as a molecular marker in sheep resistant selection breeding. Here, we review the progress of E35K mutation in sheep TMEM154 gene and its effects on resistance to MVV, and other lentivirusresistant genes including zinc finger cluster, chemokine reveptor 5 (CCR5), tripartite motif-containing 5 alpha (TRIM5α), apolipoprotein B mRNA-editing catalytic polypetide like 3 (APOBEC3), developmental pluripotencyassociated 2 (DPPA2) and DPPA4. Furthermore, SRLVs and the epidemic status are introduced. We hope to provide some guidance for sheep re-sistant breeding.

Key words: ovine lentivirus, maedi-visna virus, TMEM154 gene, mutation, resistance