遗传 ›› 2003, Vol. 25 ›› Issue (5): 620-622.
唐荣华1;2;张君诚2;庄伟建2;吴为人2 TANG Rong-Hua1;2;ZHANG Jun-Cheng2;ZHUANG Wei-Jian2;WU Wei-Ren2
摘要: 本文综述了拟南芥SUPERMAN基因表观突变体clark kent(clk)的表型、基因型、DNA甲基化及表观突变机制等方面的研究进展。主要研究结果有:clk是SUPERMAN(SUP)的等位基因,能遗传但不稳定,其对称位点(CpG和CPXPG)和非对称位点的胞嘧啶高度甲基化,伴随着SUP转录水平的下降;CpG和CPXPG胞嘧啶甲基转移酶分别是METHYLTRANSFERASE1(MET1)和受KRYPTONITE基因调控的CHROMOMETHYLASE3 (CMT3)。
Abstract:The SUPERMAN gene in Arabidopsis has its epigenetic mutants (the clark kent alleles,clk). The phenotype of clk and its genotype and methylated patterns and the epi-mutation mechanisms of SUPERMAN were summarized in the review. Heritable but unstable sup epi-alleles are associated with nearly identical patterns of excess cytosine methylation within the SUP gene and a decreased level of SUP RNA. The methylation of cytosine at CpG and CPXPG is controlled by METHYLTRANSFERASE1(MET1)and CHROMOMETHYLASE3 (CMT3) which is regulated by KRYPTONITE gene,respectively.