调控褐色脂肪细胞分化的microRNAs

doi:10.16288/j.yczz.14-360

遗传 ›› 2015, Vol. 37 ›› Issue (3): 240-249.doi: 10.16288/j.yczz.14-360

调控褐色脂肪细胞分化的microRNAs

郭云涛,苗向阳

中国农业科学院北京畜牧兽医研究所,北京 100193

收稿日期:2014-10-19 修回日期:2014-12-16 出版日期:2015-03-20 发布日期:2015-02-10
通讯作者: 苗向阳,研究员,博士,博士生导师,研究方向：基因工程与功能基因组学及转基因动物。E-mail: mxy32@sohu.com E-mail:yuntao008@126.com
作者简介:郭云涛,硕士,专业方向：转基因与细胞工程。E-mail: yuntao008@126.com
基金资助:
转基因生物新品种培育科技重大专项(编号：2009ZX08008-004B, 2008ZX08008-003),国家高技术研究发展计划(863计划)项目(编号：2008AA10Z140),国家自然科学基金项目(编号：30571339),中国农业科学院创新基金项目(编号：2004-院-1),中央级公益性科研院所基本科研业务费专项资金项目(编号：2013ywf-yb-5, 2013ywf-zd-2)和中国农业科学院农业科技创新项目(编号：ASTIP-IAS05)资助

MicroRNAs in the regulation of brown adipocyte differentiation

Yuntao Guo, Xiangyang Miao

Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2014-10-19 Revised:2014-12-16 Online:2015-03-20 Published:2015-02-10

摘要/Abstract

摘要： MicroRNA(miRNA)是近年来在真核生物中发现的一类长约22nt的内源性非编码RNA,在动物中主要通过抑制靶mRNA翻译,在转录后水平调控基因表达。动物体内有两种类型的脂肪组织：褐色和白色脂肪,白色脂肪以甘油三脂形式贮存能量,而褐色脂肪利用甘油三酯产生能量。褐色脂肪因其对肥胖的拮抗作用而对研究肥胖等代谢疾病具有重要意义,大量研究表明miRNA在褐色脂肪细胞分化中扮演着重要角色,其自身也受到多种转录因子和环境因子调控,这个复杂的调控网络维持了体内脂肪组织稳态。文章主要综述了miRNA在褐色脂肪细胞分化中的最新研究进展,以期为利用miRNA进行肥胖、糖尿病等相关疾病及其并发症的治疗提供新思路。

关键词: microRNA, 褐色脂肪细胞, 分化

Abstract: MicroRNAs (miRNAs), a class of endogenous non-coding RNA about 22 nucleotide long, regulate gene expression at the post-transcription level by inhibiting the translation or inducing the degradation of their target mRNAs in organisms. There are two types of adipose tissues: brown and white. White adipose tissues store energy in the form of triglycerides (TGs), while brown adipose tissues catabolize TGs to generate energy. Brown adipose tissues are of great importance to the research of obesity and related metabolic diseases due to their function of preventing people from obesity. A lot of studies have revealed that miRNAs play crucial roles in regulating brown adipocyte differentiation and are modulated by lots of transcription factors and environmental factors, which form a complex regulatory network maintaining the homeostasis of adipose tissues. In this review, we summarize the latest studies of miRNAs in brown adipocyte differentiation, which might provide new strategies for the treatment of obesity and other related diseases.

Key words: microRNA, brown adipocyte, differentiation

郭云涛, 苗向阳. 调控褐色脂肪细胞分化的microRNAs[J]. 遗传, 2015, 37(3): 240-249.

Yuntao Guo, Xiangyang Miao. MicroRNAs in the regulation of brown adipocyte differentiation[J]. HEREDITAS(Beijing), 2015, 37(3): 240-249.

参考文献

[1] Lean MEJ, Han TS, Seidell JC. Impairment of health and quality of life in people with large waist circumference. Lancet , 1998, 351(9106): 853-856.
[2] Cummings DE, Schwartz MW. Genetics and pathophysiology of human obesity. Annu Rev Med , 2003, 54: 453- 471.
[3] Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol , 2008, 9(5): 367-377.
[4] Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol , 2006, 7(12): 885-896.
[5] Connolly E, Morrisey RD, Carnie JA. The effect of interscapular brown adipose tissue removal on body-weight and cold response in the mouse. Br J Nutr , 1982, 47(3): 653-658.
[6] Lowell BB, S-Susulic V, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP, Flier JS. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature , 1993, 366 (6457): 740-742.
[7] Hamann A, Flier JS, Lowell BB. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology , 1996, 137(1): 21-29.
[8] Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med , 2009, 360(15): 1509-1517.
[9] Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmuller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J. Brown adipose tissue activity controls triglyceride clearance. Nat Med , 2011, 17(2): 200-205.
[10] Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell , 2005, 120(1): 15-20.
[11] He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet , 2004, 5(7): 522-531.
[12] Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell , 2009, 136(2): 215-233.
[13] Lee Y, Ahn C, Han JJ, Choi H, Kim J, Yim J, Lee J, Provost P, Radmark O, Kim S, Kim VN. The nuclear RNase III Drosha initiates microRNA processing. Nature , 2003, 425(6956): 415-419.
[14] Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin -4 encodes small RNAs with antisense complementarity to lin -14. Cell , 1993, 75(5): 843- 854.
[15] Ambros V. MicroRNA pathways in flies and worms. Cell , 2003, 113(6): 673-676.
[16] Hyun S, Lee JH, Jin H, Nam J, Namkoong B, Lee G, Chung J, Kim VN. Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K. Cell , 2009, 139(6): 1096-1108.
[17] Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex. Nature , 2009, 460(7259): 1154-1158.
[18] Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch. Nature , 2008, 454(7207): 961-967.
[19] Sun TW, Fu MG, Bookout AL, Kliewer SA, Mangelsdorf DJ. MicroRNA let -7 regulates 3T3-L1 adipogenesis. Mol Endocrinol , 2009, 23(6): 925-931.
[20] Andersen DC, Jensen CH, Schneider M, Nossent AY, Eskildsen T, Hansen JL, Teisner B, Sheikh SP. MicroRNA-15a fine-tunes the level of Delta-like 1 homolog (DLK1) in proliferating 3T3-L1 preadipocytes. Exp Cell Res , 2010, 316(10): 1681-1691.
[21] Li HL, Li TP, Wang SH, Wei JF, Fan JF, Li J, Han Q, Liao LM, Shao CS, Zhao RC. miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells. Stem Cell Res , 2013, 10(3): 313-324.
[22] Wang Q, Li YC, Wang JH, Kong J, Qi YC, Quigg RJ, Li XM. miR-17

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

调控褐色脂肪细胞分化的microRNAs

MicroRNAs in the regulation of brown adipocyte differentiation

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	吴玲玲, 张小玉, 李晓, 靳建军, 杨公社, 史新娥. miR-196b-5p促进成肌细胞增殖分化[J]. 遗传, 2023, 45(5): 435-446.
[2]	孙凤宇, 许强华. 血液发生相关microRNAs研究进展[J]. 遗传, 2022, 44(9): 756-771.
[3]	赵欢, 周斌. 胰岛beta细胞再生研究进展[J]. 遗传, 2022, 44(5): 370-382.
[4]	余志鑫, 李鹏宇, 李凯, 缪时英, 王琳芳, 宋伟. 精原干细胞微环境研究进展[J]. 遗传, 2022, 44(12): 1103-1116.
[5]	张恩权, 蔡伟聪, 李桂玲, 李健, 刘静雯. 赫氏颗石藻(Emiliania huxleyi)响应病毒感染的microRNA转录组分析[J]. 遗传, 2021, 43(11): 1088-1100.
[6]	邹礼平, 潘铖, 王梦馨, 崔林, 韩宝瑜. 激素调控植物成花机理研究进展[J]. 遗传, 2020, 42(8): 739-751.
[7]	杜坤, 毛初阳, 任安勇, 吴雪梅, 李庆玲, 陈婷婷, 陈仕毅, 赖松家. 家兔前体脂肪细胞分化不同时期基因表达谱分析[J]. 遗传, 2020, 42(3): 309-320.
[8]	赵晓琪, 敖英, 陈海云, 汪晖. miRNA与肾脏发育[J]. 遗传, 2020, 42(11): 1062-1072.
[9]	陈万银, 颜一丹, 栾晓瑾, 王敏, 方杰. CG8005基因在果蝇睾丸生殖细胞中的功能分析[J]. 遗传, 2020, 42(11): 1122-1132.
[10]	杨科, 薛征, 吕湘. 细胞终末分化过程中三维基因组结构与功能调控的分子机制[J]. 遗传, 2020, 42(1): 32-44.
[11]	尹玲倩,冉金山,李菁菁,任鹏,张贤娴,刘益平. 禽类就巢性状的遗传调控[J]. 遗传, 2019, 41(5): 391-403.
[12]	黄子莹, 李龙, 李倩倩, 刘向东, 李长春. lncRNA TCONS_00815878对猪骨骼肌卫星细胞分化的影响[J]. 遗传, 2019, 41(12): 1119-1128.
[13]	李欢, 冯晋川, 李贵林, 王讯, 李明洲, 刘海峰. Lnc-RAP3对小鼠3T3-L1前脂肪细胞分化的影响[J]. 遗传, 2018, 40(9): 758-766.
[14]	任岚,肖茹丹,张倩,娄晓敏,张昭军,方向东. KLF1和KLF9对K562细胞红系分化的协同调控作用[J]. 遗传, 2018, 40(11): 998-1006.
[15]	杨熳,卢冰婕,段媛媛,陈晓峰,马建岗,郭燕. 骨质疏松症易感基因BDNF的遗传学关联分析及功能研究[J]. 遗传, 2017, 39(8): 726-736.