遗传 ›› 2015, Vol. 37 ›› Issue (3): 240-249.doi: 10.16288/j.yczz.14-360
郭云涛,苗向阳
收稿日期:2014-10-19
修回日期:2014-12-16
出版日期:2015-03-20
发布日期:2015-02-10
通讯作者:
苗向阳,研究员,博士,博士生导师,研究方向：基因工程与功能基因组学及转基因动物。E-mail: mxy32@sohu.com
E-mail:yuntao008@126.com
作者简介:郭云涛,硕士,专业方向：转基因与细胞工程。E-mail: yuntao008@126.com
基金资助:Yuntao Guo, Xiangyang Miao
Received:2014-10-19
Revised:2014-12-16
Online:2015-03-20
Published:2015-02-10
摘要： MicroRNA(miRNA)是近年来在真核生物中发现的一类长约22nt的内源性非编码RNA,在动物中主要通过抑制靶mRNA翻译,在转录后水平调控基因表达。动物体内有两种类型的脂肪组织：褐色和白色脂肪,白色脂肪以甘油三脂形式贮存能量,而褐色脂肪利用甘油三酯产生能量。褐色脂肪因其对肥胖的拮抗作用而对研究肥胖等代谢疾病具有重要意义,大量研究表明miRNA在褐色脂肪细胞分化中扮演着重要角色,其自身也受到多种转录因子和环境因子调控,这个复杂的调控网络维持了体内脂肪组织稳态。文章主要综述了miRNA在褐色脂肪细胞分化中的最新研究进展,以期为利用miRNA进行肥胖、糖尿病等相关疾病及其并发症的治疗提供新思路。
郭云涛, 苗向阳. 调控褐色脂肪细胞分化的microRNAs[J]. 遗传, 2015, 37(3): 240-249.
Yuntao Guo, Xiangyang Miao. MicroRNAs in the regulation of brown adipocyte differentiation[J]. HEREDITAS(Beijing), 2015, 37(3): 240-249.
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