LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展

doi:10.16288/j.yczz.17-358

遗传 ›› 2018, Vol. 40 ›› Issue (4): 292-304.doi: 10.16288/j.yczz.17-358

LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展

周瑞,王以鑫,龙科任,蒋岸岸,金龙()

四川农业大学,畜禽遗传资源发掘与创新利用四川省重点实验室,成都 611130

收稿日期:2017-12-18 修回日期:2018-03-01 出版日期:2018-04-20 发布日期:2018-03-19
通讯作者: 金龙 E-mail:longjin@sicau.edu.cn
作者简介:周瑞,硕士研究生,专业方向：动物遗传育种与繁殖。E-mail: 948417369@qq.com
基金资助:
国家自然科学基金项目(31601919);国家自然科学基金项目(31772576);国家自然科学基金项目(31522055);四川省教育厅项目(16ZB0037);四川省省院省校科技合作研发项目(2017JZ0025);四川省青年科技创新研究团队资助(2015TD0012)

Regulatory mechanism for lncRNAs in skeletal muscle development and progress on its research in domestic animals

Zhou Rui,Wang Yixin,Long Keren,Jiang Anan,Jin Long()

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China

Received:2017-12-18 Revised:2018-03-01 Online:2018-04-20 Published:2018-03-19
Contact: Jin Long E-mail:longjin@sicau.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(31601919);Supported by the National Natural Science Foundation of China(31772576);Supported by the National Natural Science Foundation of China(31522055);the Project of Sichuan Education Department(16ZB0037);the Project of Sichuan Provincial and Municipal Science and Technology Cooperation in Research and Development(2017JZ0025);Sichuan Youth Science and Technology Innovation Research Team(2015TD0012)

摘要/Abstract

摘要：

骨骼肌是维持机体功能必不可少的组织,与家养动物的产肉率等重要经济性状密切相关。近年来,高通量测序鉴定了大量与骨骼肌生成相关的长链非编码RNA (long non-coding RNA, lncRNA),它们可作为调节因子在表观调控、转录调控以及转录后调控等多个层面调控基因表达。lncRNA通过靶向关键因子参与调控骨骼肌发育的各个环节,包括骨骼肌干细胞增殖、迁移、分化,成肌细胞增殖、分化、肌管融合,肌纤维肥大和纤维类型转换等过程。本文重点归纳了lncRNA在人和小鼠骨骼肌发育中的分子调控机制,介绍了lncRNA的研究方法,综述了lncRNA在家养动物骨骼肌发育中的研究进展,分析了目前家养动物lncRNA研究所面临的困难和挑战,最后展望了未来家养动物lncRNA研究的方向,以期为进一步阐明骨骼肌生长发育的分子调控机制提供参考。

关键词: 长链非编码RNA, 骨骼肌, 作用机制, 发育, 家养动物

Abstract:

Skeletal muscle is an essential tissue to maintain the normal functions of an organism. It is also closely associated with important economic performance, such as carcass weight, of domestic animals. In recent years, studies using high-throughput sequencing techniques have identified numerous long non-coding RNAs (lncRNAs) with myogenic functions involved in regulation of gene expression at multiple levels, including epigenetic, transcriptional and post-transcriptional regulation. These lncRNAs target myogenic factors, which participate in all processes of skeletal muscle development, including proliferation, migration and differentiation of skeletal muscle stem cells, proliferation, differentiation and fusion of myocytes, muscle hypertrophy and conversion of muscle fiber types. In this review, we summarize the functional roles of lncRNAs in regulation of myogenesis in humans and mice, describe the methods for the analysis of lncRNA function, discuss the progress of lncRNA research in domestic animals, and highlight the current problems and challenges in lncRNA research on livestock production. We hope to provide a useful reference for research on lncRNA in domestic animals, thereby further identifying the molecular regulatory mechanisms in skeletal muscle growth and development.

Key words: long non-coding RNAs, skeletal muscle, acting mechanism, development, domestic animals

周瑞,王以鑫,龙科任,蒋岸岸,金龙. LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展[J]. 遗传, 2018, 40(4): 292-304.

Zhou Rui,Wang Yixin,Long Keren,Jiang Anan,Jin Long. Regulatory mechanism for lncRNAs in skeletal muscle development and progress on its research in domestic animals[J]. Hereditas(Beijing), 2018, 40(4): 292-304.

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LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展

Regulatory mechanism for lncRNAs in skeletal muscle development and progress on its research in domestic animals

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