关键词: 男性不育, 遗传因素, 非梗阻性无精子症, 精子畸形, 鞭毛多发性形态异常, 原发性纤毛运动障碍。

Abstract: About 15% couples suffer from infertility, half of which are caused by male factors. Male infertility usually manifests as teratozoospermia, oligospermia and/or asthenospermia, of which the most severe form is azoospermia. Recently, with the fast development of high-throughput chips and sequencing technologies, many genetic factors of male infertility have been discovered and analyzed. The discovery of a series of disease genes helped the characterization of the pathological mechanisms of male infertility. Therefore, a comprehensive and in-depth understanding of genetic factors in male infertility will play important roles in the clinical diagnosis, treatment and genetic counseling of male infertility.

Key words: male infertility, genetics, Nonobstructive azoospermia (NOA), teratozoospermia, Multiple morphological abnormalities of the flagella (MMAF), primary ciliary dyskinesia (PCD)