遗传 ›› 2016, Vol. 38 ›› Issue (9): 791-800.doi: 10.16288/j.yczz.16-120
董莲花1, 2, 冉茂良1, 2, 李智1, 2, 彭馥芝1, 2, 陈斌1, 2
收稿日期:2016-04-05
出版日期:2016-09-20
发布日期:2016-09-20
通讯作者:
陈斌,博士,教授,博士生导师,研究方向：动物遗传育种。E-mail: chenbin7586@126.com
作者简介:董莲花,硕士研究生,专业方向：动物遗传育种。E-mail: donglianhua013@126.com
基金资助:Lianhua Dong1, 2, Maoliang Ran1, 2, Zhi Li1, 2, Fuzhi Peng1, 2, Bin Chen1, 2
Received:2016-04-05
Online:2016-09-20
Published:2016-09-20
Supported by:摘要： 泛素-蛋白酶体途径(Ubiquitin-proteasome pathway,UPP)是真核细胞内蛋白质主要降解途径,通过调节蛋白质相互作用、蛋白活性、蛋白定位及信号转导,进而在细胞周期进程、细胞凋亡、应激反应及机体生长发育等过程发挥重要作用。研究表明,UPP在人和动物精子生成中的顶体生物合成及精子尾部形成过程起着关键的调控作用,精子变态过程中UPP调控异常导致精子畸形及精子活力降低,并引发少精子症、不育及睾丸肿瘤等生殖系统疾病。本文综述了UPP在动物精子生成过程中的信号传导及调节机制,以期为后续相关研究提供参考。
董莲花, 冉茂良, 李智, 彭馥芝, 陈斌. 泛素-蛋白酶体途径在精子生成中的作用[J]. 遗传, 2016, 38(9): 791-800.
Lianhua Dong, Maoliang Ran, Zhi Li, Fuzhi Peng, Bin Chen. The role of ubiquitin-proteasome pathway in spermatogenesis[J]. Hereditas(Beijing), 2016, 38(9): 791-800.
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