遗传 ›› 2010, Vol. 32 ›› Issue (3): 211-218.doi: 10.3724/SP.J.1005.2010.00211

• 综述 • 上一篇    下一篇

马基因组研究进展

杨虹1, 马月辉2, 李蓓1, 芒来1   

  1. 1. 内蒙古农业大学动物科学与医学学院, 呼和浩特 010018; 
    2. 中国农业科学院北京畜牧兽医研究所, 北京 100193
  • 收稿日期:2009-08-06 修回日期:2009-10-19 出版日期:2010-03-20 发布日期:2010-03-15
  • 通讯作者: 芒来 E-mail:dmanglai@yahoo.com.cn
  • 基金资助:

    国家自然科技平台建设项目(编号:2005DKA21101)和国家自然科学基金项目(编号:30760162)资助

Progress on horse genome project

YANG Hong1, MA Yue-Hui2, LI Bei1, Dugarjaviin Manglai1   

  1. 1. College of Animal Science and Animal Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China; 
    2. Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing 100193, China
  • Received:2009-08-06 Revised:2009-10-19 Online:2010-03-20 Published:2010-03-15
  • Contact: HUANG Lai E-mail:dmanglai@yahoo.com.cn

摘要:

各种生物都具有其独特的遗传信息, 深入了解生物体的形成过程以及各种生命活动都离不开基因组的研究成果。由于在世界范围内马具有良好的健康情况记录和详细的系谱记录, 使得马成为生命科学研究中极具价值的模式动物。尽管起步较晚, 但在过去的几年中, 马基因组图谱经历了前所未有的发展。文章主要对近年来马基因组遗传图谱、物理图谱、基因组比较作图以及功能基因组学等研究进展进行了综述, 这些图谱也正是世界各地研究人员用以探寻与马的各种性状(包括全部的健康状况、抗病性能、生殖生育能力、运动性能以及诸如毛色这样的表型特征等)相关基因的重要工具。相信这些研究成果将为马匹疾病预防、诊断和治疗提供新的思路与方法, 并将为马遗传育种提供更好的选配依据。

关键词: 马, 基因组图谱, 基因组测序, 比较基因组, 基因组分析

Abstract:

There is unique genetic information belonging to various kinds of living beings. Understanding of the formation process of organisms and a variety of vital movement is associated with the achievements of genome study. As horse has a notable health condition and great record of the genealogy in the world, thus it becomes a valuable model animal for studying life science. Despite of a late start, the map of the horse genome has undergone unprecedented expansion during the last few years. The current progresses of the horse genome, including genetic map, physical map, comparative genomic map, and functional genomics, were reviewed in this paper. The maps are currently used worldwide to discover genes associated with various traits of significance in horse including general health, disease resistance, reproduction, fertility, athletic performance, phenotypic characteristics like coat color, etc. The results are believed to provide new ideas and approaches for prevention, diagnostics, and therapeutic for horses, and also better foundation of breed selection and equine genetic breeding.

Key words: horse, genome map, genome sequencing, comparative genomics, genome analysis