Sp1/Krüppel样因子的研究进展

doi:10.3724/SP.J.1005.2010.00531

遗传 ›› 2010, Vol. 32 ›› Issue (6): 531-538.doi: 10.3724/SP.J.1005.2010.00531

Sp1/Krüppel样因子的研究进展

熊倩^{1, 2}, 阮修艳¹, 方向东¹

中国科学院北京基因组研究所

收稿日期:2009-09-15 修回日期:2009-10-27 出版日期:2010-06-20 发布日期:2010-05-24
通讯作者: 方向东 E-mail:fangxd@big.ac.cn
基金资助:
国家自然科学基金项目(编号: 30971673)和中国科学院知识创新工程青年人才领域前沿项目资助

Progress on Sp1-like and Krüppel-like factors

XIONG Qian^1,2, RUAN Xiu-Yan¹, FANG Xiang-Dong¹

1．Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China; 2．Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2009-09-15 Revised:2009-10-27 Online:2010-06-20 Published:2010-05-24
Contact: FANG Xiang-Dong E-mail:fangxd@big.ac.cn

摘要/Abstract

摘要：

Sp1/Krüppel样因子(Sp1-like and Krüppel-like factors, Sp1/KLFs)是一组与真核细胞转录调控密切相关的锌指蛋白。Sp1/KLFs的羧基末端高度保守, 含有3个串联的Cys₂His₂锌指结构, 用于结合DNA; 其氨基末端在不同的家族成员间存在较大差异, 主要是通过结合辅助因子发挥转录调控作用。Sp1/KLFs的表达具有组织、细胞分布以及发育时期的特异性, 它们通过调控多种富含GC或CACCC的启动子的基因的表达, 参与细胞增殖、分化、凋亡和肿瘤发生、发展等多种生理、病理过程。文章综述了Sp1/KLFs的结构特征、作用机制及生物学功能。

关键词: Sp1/Krüppel样因子, 锌指区, 转录调控

Abstract:

Sp1-like and Krüppel-like factors (Sp1/KLFs) are a family of zinc-finger proteins that are important components of transcriptional machinery in eukaryotic cells. Sp1/KLFs have highly conserved DNA binding domains at the carboxyl terminus that have three tandem zinc-finger motifs. Their amino terminal regions vary greatly and contain transcription regulatory domains that interact with co-regulators. By regulating the expression of a large number of genes containing GC-rich or CACCC promoters in a tissue-, cell- and developmental stage-specific manner, Sp1/KLFs may be involved in many biological processes, including cell proliferation, differentiation, apoptosis and neoplastic transformation. In this arti-cle, we reviewed the structure, molecular mechanisms and biological functions of Sp1/KLFs.

Key words: Sp1-like and Krüppel-like factors, zinc-finger domain, transcriptional regulating

熊倩，阮修艳，方向东. Sp1/Krüppel样因子的研究进展[J]. 遗传, 2010, 32(6): 531-538.

XIONG Qian, RUAN Xiu-Yan, FANG Xiang-Dong. Progress on Sp1-like and Krüppel-like factors[J]. HEREDITAS, 2010, 32(6): 531-538.

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Sp1/Krüppel样因子的研究进展

Progress on Sp1-like and Krüppel-like factors

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