[1]张石革. 免疫抑制剂的进展与临床应用评价. 中国医院用药评价与分析, 2008, 8(11): 803-808.
[2]Schreiber SL. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science, 1991, 251(4991): 283-287.
[3]Fruman DA, Burakoff SJ, Bierer BE. Immunophilins in protein folding and immunosuppression. FASEB J, 1994, 8(6): 391-400.
[4]Baumann G. Molecular mechanism of immunosuppressive agents. Transplant Proc, 1992, 24(4 Suppl 2): 4-7.
[5]Gold BG, Storm-Dickerson T, Austin DR. The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor Neurol Neurosci, 1994, 6(4): 287-296.
[6]Sigal NH, Dumont FJ. Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu Rev Immunol, 1992, 10: 519-560.
[7]Harding MW, Galat A, Uehling DE, Schreiber SL. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature, 1989, 341(6244): 758- 760.
[8]Siekierka JJ, Staruch MJ, Hung SH, Sigal NH. FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin. J Immunol, 1989, 143(5): 1580-1583.
[9]Fischer G, Bang H, Mech C. Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides. Biomed Biochim Acta, 1984, 43(10): 1101-1111.
[10]Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J. Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex. Science, 1991, 252(5007): 839-842.
[11]He ZY, Li LG, Luan S. Immunophilins and parvulins. Superfamily of peptidyl prolyl isomerases in Arabidopsis. Plant Physiol, 2004, 134(4): 1248-1267.
[12]Gollan PJ, Bhave M. Genome-wide analysis of genes encoding FK506-binding proteins in rice. Plant Mol Biol 2010, 72(1-2): 1-16.
[13]Yu YL, Zhang H, Li WC, Zhang FJ, Mu CH, Wang LM, Meng ZD. Genome-wide analysis and environmental response profiling of the FK506-binding protein gene family in maize (Zea mays L.). Gene, 2012, 498(2): 212-222.
[14]Breiman A, Fawcett TW, Ghirardi ML, Mattoo AK. Plant organelles contain distinct peptidylprolyl cis, trans- isomerases. J Biol Chem, 1992, 267(30): 21293-21296.
[15]Breiman A, Camus I. The involvement of mammalian and plant FK506-binding proteins (FKBPs) in development. Transgenic Res, 2002, 11(4): 321-335.
[16]Geisler M, Bailly A. Tete-a-tete: the function of FKBPs in plant development. Trends Plant Sci, 2007, 12(10): 465- 473.
[17]Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J. Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. J Mol Biol, 1993, 229(1): 105-124.
[18]Patterson CE, Gao JM, Rooney AP, Davis EC. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. Genomics, 2002, 79(6): 881-889.
[19]Somarelli JA, Lee SY, Skolnick J, Herrera RJ. Structure-based classification of 45 FK506-binding proteins. Proteins, 2008, 72(1): 197-208.
[20]Fanghänel J, Fischer G. Insights into the catalytic mechanism of peptidyl prolyl cis/trans isomerases. Front Biosci, 2004, 9: 3453-3478.
[21]Gollan PJ, Bhave M, Aro EM. The FKBP families of higher plants: Exploring the structures and functions of protein interaction specialists. FEBS Lett, 2012, 586(20): 3539-3547.
[22]Szep S, Park S, Boder ET, Van Duyne GD, Saven JG. Structural coupling between FKBP12 and buried water. Proteins, 2009, 74(3): 603-611.
[23]Xu Q, Liang SP, Kudla J, Luan S. Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin. Plant J, 1998, 15(4): 511-519.
[24]Faure JD, Gingerich D, Howell SH. An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506. Plant J, 1998, 15(6): 783-789.
[25]Agredano-Moreno LT, Reyes de la Cruz H, Martinez-Castilla LP, Sánchez de Jimenez E. Distinctive expression and functional regulation of the maize (Zea mays L.) TOR kinase ortholog. Mol Biosyst, 2007, 3(11): 794- 802.
[26]Yu YL, Li YZ, Huang GX, Meng ZD, Zhang D, Wei J, Yan K, Zheng CH, Zhang LY. PwHAP5, a CCAAT-binding transcription factor, interacts with PwFKBP12 and plays a role in pollen tube growth orientation in Picea wilsonii. J Exp Bot, 2011, 62(14): 4805-4817.
[27]Vespa L, Vachon G, Berger F, Perazza D, Faure JD, Herzog M. The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication. Plant Physiol, 2004, 134(4): 1283-1292.
[28]Kamphausen T, Fanghänel J, Neumann D, Schulz B, Rahfeld JU. Characterization of Arabidopsis thaliana AtFKBP42 that is membrane-bound and interacts with Hsp90. Plant J, 2002, 32(3): 263-276.
[29]Geisler M, Kolukisaoglu HÜ, Bouchard R, Billion K, Berger J, Saal B, Frangne N, Koncz-Kalman Z, Koncz C, Dudler R, Blakeslee JJ, Murphy AS, Martinoia E, Schulz B. TWISTED DWARF1, a unique plasma membrane- anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19. Mol Biol Cell, 2003, 14(10): 4238-4249.
[30]Henrichs S, Wang BJ, Fukao Y, Zhu JS, Charrier L, Bailly A, Oehring SC, Linnert M, Weiwad M, Endler A, Nanni P, Pollmann S, Mancuso S, Schulz A, Geisler M. Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation. EMBO J, 2012, 31(13): 2965-2980.
[31]Titapiwatanakun B, Blakeslee JJ, Bandyopadhyay A, Yang HB, Mravec J, Sauer M, Cheng Y, Adamec J, Nagashima A, Geisler M, Sakai T, Friml J, Peer WA, Murphy AS. ABCB19/PGP19 stabilises PIN1 in membrane microdomains in Arabidopsis. Plant J, 2009, 57(1): 27-44.
[32]Wu GS, Otegui MS, Spalding EP. The ER-localized TWD1 immunophilin is necessary for localization of multidrug resistance-like proteins required for polar auxin transport in Arabidopsis roots. Plant Cell, 2010, 22(10): 3295-3304.
[33]Geisler M, Girin M, Brandt S, Vincenzetti V, Plaza S, Paris N, Kobae Y, Maeshima M, Billion K, Kolukisaoglu UH, Schulz B, Martinoia E. Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Mol Biol Cell, 2004, 15(7): 3393-3405.
[34]Vucich VA, Gasser CS. Novel structure of a high molecular weight FK506 binding protein from Arabidopsis thaliana. Mol Gen Genet, 1996, 252(5): 510-517.
[35]Blecher O, Erel N, Callebaut I, Aviezer K, Breiman A. A novel plant peptidyl-prolyl-cis-trans-isomerase (PPIase): cDNA cloning, structural analysis, enzymatic activity and expression. Plant Mol Biol, 1996, 32(3): 493-504.
[36]Magiri EN, Farchi-Pisanty O, Avni A, Breiman A. The expression of the large rice FK506 binding proteins (FKBPs) demonstrate tissue specificity and heat stress responsiveness. Plant Sci, 2006, 170(4): 695-704.
[37]Gu SH, Zhang F, Wu NH. OsFKBP1 interacts with phytochrome B in rice. Prog Nat Sci, 2009, 19(11): 1523-1528.
[38]Hueros G, Rahfeld J, Salamini F, Thompson R. A maize FK506-sensitive immunophilin, mzFKBP-66, is a peptidylproline cis-trans-isomerase that interacts with calmodulin and a 36-kDa cytoplasmic protein. Planta, 1998, 205(1): 121-131.
[39]Meiri D, Breiman A. Arabidopsis ROF1 (FKBP62) modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs. Plant J, 2009, 59(3): 387-399.
[40]Meiri D, Tazat K, Cohen-Peer R, Farchi-Pisanty O, Aviezer-Hagai K, Avni A, Breiman A. Involvement of Arabidopsis ROF2 (FKBP65) in thermotolerance. Plant Mol Biol, 2010, 72(1-2): 191-203.
[41]Bissoli G, Ninoles R, Fresquet S, Palombieri S, Bueso E, Rubio L, Garcia-Sanchez MJ, Fernandez JA, Mulet JM, Serrano R. Peptidyl-prolyl cis-trans isomerase ROF2 modulates intracellular pH homeostasis in Arabidopsis. Plant J, 2012, 70(4): 704-716.
[42]Aviezer-Hagai K, Skovorodnikova J, Galigniana M, Farchi-Pisanty O, Maayan E, Bocovza S, Efrat Y, von Koskull-Doring P, Ohad N, Breiman A. Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced, and bind HSP90. Plant Mol Biol, 2007, 63(2): 237-255.
[43]Kurek I, Aviezer K, Erel N, Herman E, Breiman A. The wheat peptidyl prolylcis-trans-isomerase FKBP77 is heat induced and developmentally regulated. Plant Physiol, 1999, 119(2): 693-704.
[44]Vittorioso P, Cowling R, Faure JD, Caboche M, Bellini C. Mutation in the Arabidopsis PASTICCINO1 gene, which encodes a new FK506-binding protein-like protein, has a dramatic effect on plant development. Mol Cell Biol, 1998, 18(5): 3034-3043.
[45]Carol RJ, Breiman A, Erel N, Vittorioso P, Bellini C. PASTICCINO1 (AtFKBP70) is a nuclear-localised immunophilin required during Arabidopsis thaliana embryogenesis. Plant Science, 2001, 161(3): 527-535.
[46]Smyczynski C, Roudier F, Gissot L, Vaillant E, Grandjean O, Morin H, Masson T, Bellec Y, Geelen D, Faure JD. The C terminus of the immunophilin PASTICCINO1 is required for plant development and for interaction with a NAC-like transcription factor. J Biol Chem, 2006, 281(35): 25475-25484.
[47]Roudier F, Gissot L, Beaudoin F, Haslam R, Michaelson L, Marion J, Molino D, Lima A, Bach L, Morin H, Tellier F, Palauqui JC, Bellec Y, Renne C, Miquel M, Dacosta M, Vignard J, Rochat C, Markham JE, Moreau P, Napier J, Faure JD. Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis. Plant Cell, 2010, 22(2): 364-375.
[48]Luan S, Kudla J, Gruissem W, Schreiber SL. Molecular characterization of a FKBP-type immunophilin from higher plants. Proc Natl Acad Sci USA, 1996, 93(14): 6964-6969.
[49]Nigam N, Singh A, Sahi C, Chandramouli A, Grover A. SUMO-conjugating enzyme (Sce) and FK506-binding protein (FKBP) encoding rice (Oryza sativa L.) genes: genome-wide analysis, expression studies and evidence for their involvement in abiotic stress response. Mol Genet Genomics, 2008, 279(4): 371-383.
[50]Jääskeläinen T, Makkonen H, Palvimo JJ. Steroid up-regulation of FKBP51 and its role in hormone signaling. Curr Opin Pharmacol, 2011, 11(4): 326-331.
[51]Li H, Luan S. AtFKBP53 is a histone chaperone required for repression of ribosomal RNA gene expression in Arabidopsis. Cell Res, 2010, 20(3): 357-366.
[52]Luan S, Albers MW, Schreiber SL. Light-regulated, tissue-specific immunophilins in a higher plant. Proc Natl Acad Sci USA, 1994, 91(3): 984-988.
[53]Gupta R, Mould RM, He ZY, Luan S. A chloroplast FKBP interacts with and affects the accumulation of Rieske subunit of cytochrome bf complex. Proc Natl Acad Sci USA, 2002, 99(24): 15806-15811.
[54]Gollan PJ, Ziemann M, Bhave M. PPIase activities and interaction partners of FK506-binding proteins in the wheat thylakoid. Physiol Plant, 2011, 143(4): 385-395.
[55]Edvardsson A, Shapiguzov A, Petersson UA, Schröder WP, Vener AV. Immunophilin AtFKBP13 sustains all peptidyl-prolyl isomerase activity in the thylakoid lumen from Arabidopsis thaliana deficient in AtCYP20-2. Biochemistry, 2007, 46(33): 9432-9442.
[56]Gopalan G, He ZY, Balmer Y, Romano P, Gupta R, Héroux A, Buchanan BB, Swaminathan K, Luan S. Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen. Proc Natl Acad Sci USA, 2004, 101(38): 13945-13950.
[57]Lima A, Lima S, Wong JH, Phillips RS, Buchanan BB, Luan S. A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana. Proc Natl Acad Sci USA, 2006, 103(33): 12631-12636.
[58]Edlich F, Weiwad M, Erdmann F, Fanghänel J, Jarczowski F, Rahfeld JU, Fischer G. Bcl-2 regulator FKBP38 is activated by Ca²⁺/calmodulin. EMBO J, 2005, 24(14): 2688- 2699.
[59]Owens-Grillo JK, Stancato LF, Hoffmann K, Pratt WB, Krishna P. Binding of immunophilins to the 90 kDa heat shock protein (hsp90) via a tetratricopeptide repeat domain is a conserved protein interaction in plants. Biochemistry, 1996, 35(48): 15249-15255.
[60]Davies TH, Sánchez ER. FKBP52. Int J Biochem Cell Biol, 2005, 37(1): 42-47.
[61]Ahn JC, Kim DW, You YN, Seok MS, Park JM, Hwang H, Kim BG, Luan S, Park HS, Cho HS. Classification of rice (Oryza sativa L. Japonica nipponbare) immunophilins (FKBPs, CYPs) and expression patterns under water stress. BMC Plant Biol, 2010, 10: 253-275.
[62]Bouchard R, Bailly A, Blakeslee JJ, Oehring SC, Vincenzetti V, Lee OR, Paponov I, Palme K, Mancuso S, Murphy AS, Schulz B, Geisler M. Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoproteins. J Biol Chem, 2006, 281(41): 30603- 30612.
[63]Bailly A, Sovero V, Vincenzetti V, Santelia D, Bartnik D, Koenig BW, Mancuso S, Martinoia E, Geisler M. Modulation of P-glycoproteins by auxin transport inhibitors is mediated by interaction with immunophilins. J Biol Chem, 2008, 283(31): 21817-21826.
[64]Scheidt HA, Vogel A, Eckhoff A, Koenig BW, Huster D. Solid-state NMR characterization of the putative membrane anchor of TWD1 from Arabidopsis thaliana. Eur Biophys J, 2007, 36(4-5): 393-404.
[65]Granzin J, Eckhoff A, Weiergräber OH. Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: a paradigm for regulation of plant ABC transporters. J Mol Biol, 2006, 364(4): 799-809.
[66]Park J, Song WY, Ko D, Eom Y, Hansen TH, Schiller M, Lee TG, Martinoia E, Lee Y. The phytochelatin transporters AtABCC1 and AtABCC2 mediate tolerance to cadmium and mercury. Plant J, 2012, 69(2): 278-288.
[67]Harrar Y, Bellec Y, Bellini C, Faure JD. Hormonal control of cell proliferation requires PASTICCINO genes. Plant Physiol, 2003, 132(3): 1217-1227.
[68]Hoekstra D, Maier O, van der Wouden JM, Slimane TA, van IJzendoorn SC. Membrane dynamics and cell polarity: the role of sphingolipids. J Lipid Res, 2003, 44(5): 869- 877.
[69]Bach L, Michaelson LV, Haslam R, Bellec Y, Gissot L, Marion J, Da Costa M, Boutin JP, Miquel M, Tellier F, Domergue F, Markham JE, Beaudoin F, Napier JA, Faure JD. The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proc Natl Acad Sci USA, 2008, 105(38): 14727-14731.
[70]Schubert M, Petersson UA, Haas BJ, Funk C, Schroder WP, Kieselbach T. Proteome map of the chloroplast lumen of Arabidopsis thaliana. J Biol Chem, 2002, 277(10): 8354-8365.
[71]Peltier JB, Emanuelsson O, Kalume DE, Ytterberg J, Friso G, Rudella A, Liberles DA, Soderberg L, Roepstorff P, von Heijne G, van Wijk KJ. Central functions of the lumenal and peripheral thylakoid proteome of Arabidopsis determined by experimentation and genome-wide prediction. Plant Cell, 2002, 14(1): 211-236.
[72]Shapiguzov A, Edvardsson A, Vener AV. Profound redox sensitivity of peptidyl-prolyl isomerase activity in Arabidopsis thylakoid lumen. FEBS Lett, 2006, 580(15): 3671- 3676.
[73]Ingelsson B, Shapiguzov A, Kieselbach T, Vener AV. Peptidyl-prolyl isomerase activity in chloroplast thylakoid lumen is a dispensable function of immunophilins in Arabidopsis thaliana. Plant Cell Physiol, 2009, 50(10): 1801-1814.
[74]Peng LW, Fukao Y, Fujiwara M, Takami T, Shikanai T. Efficient operation of NAD(P)H dehydrogenase requires supercomplex formation with photosystem I via minor LHCI in Arabidopsis. Plant Cell, 2009, 21(11): 3623- 3640.
[75]Gopalan G, He ZY, Battaile KP, Luan S, Swaminathan K. Structural comparison of oxidized and reduced FKBP13 from Arabidopsis thaliana. Proteins, 2006, 65(4): 789-795.
[76]DalCorso G, Pesaresi P, Masiero S, Aseeva E, Schunemann D, Finazzi G, Joliot P, Barbato R, Leister D. A complex containing PGRL1 and PGR5 is involved in the switch between linear and cyclic electron flow in Arabidopsis. Cell, 2008, 132(2): 273-285.
[77]Iwai M, Takizawa K, Tokutsu R, Okamuro A, Takahashi Y, Minagawa J. Isolation of the elusive supercomplex that drives cyclic electron flow in photosynthesis. Nature, 2010, 464(7292): 1210-1213.
[78]Majeran W, Zybailov B, Ytterberg AJ, Dunsmore J, Sun Q, van Wijk KJ. Consequences of C4 differentiation for chloroplast membrane proteomes in maize mesophyll and bundle sheath cells. Mol Cell Proteomics, 2008, 7(9): 1609-1638.
[79]Marivet J, Frendo P, Burkard G. DNA sequence analysis of a cyclophilin gene from maize: developmental expression and regulation by salicylic acid. Mol Gen Genet, 1995, 247(2): 222-228.
[80]Riggs DL, Cox MB, Tardif HL, Hessling M, Buchner J, Smith DF. Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling. Mol Cell Biol, 2007, 27(24): 8658- 8669.
[81]Galat A. A note on clustering the functionally-related paralogues and orthologues of proteins: a case of the FK506-binding proteins (FKBPs). Comput Biol Chem, 2004, 28(2): 129-140.
[82]Lu KP, Finn G, Lee TH, Nicholson LK. Prolyl cis-trans isomerization as a molecular timer. Nat Chem Biol, 2007, 3(10): 619-629.
[83]Li L, Lou Z, Wang L. The role of FKBP5 in cancer aetiology and chemoresistance. Br J Cancer, 2011, 104(1): 19-23.