G蛋白偶联受体3：调控神经系统和卵泡发育的关键因子

doi:10.3724/SP.J.1005.2013.00578

遗传 ›› 2013, Vol. 35 ›› Issue (5): 578-586.doi: 10.3724/SP.J.1005.2013.00578

G蛋白偶联受体3：调控神经系统和卵泡发育的关键因子

张宝乐^1,2, 高殿帅¹, 徐银学²

1. 徐州医学院神经生物学教研室, 徐州 221002 2. 南京农业大学动物科学技术学院, 南京 210095

收稿日期:2012-08-27 修回日期:2012-09-26 出版日期:2013-05-20 发布日期:2013-05-25
通讯作者: 徐银学 E-mail:xuyinxue@njau.edu.cn
基金资助:
国家高技术研究发展计划项目(863计划)(编号：2006AA10Z136)资助

G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development

ZHANG Bao-Le^1,2, GAO Dian-Shuai¹, XU Yin-Xue²

1. Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, China 2. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China

Received:2012-08-27 Revised:2012-09-26 Online:2013-05-20 Published:2013-05-25

摘要/Abstract

摘要： G蛋白偶联受体(G protein-coupled receptors, GPCRs)是细胞表面最大的受体超家族, 参与调节多种生理和病理过程。G蛋白偶联受体3(G protein-coupled receptor 3, Gpr3)是一种新发现的鞘氨醇1-磷酸受体, 它直接或者间接参与调节脊椎动物神经系统及卵泡的发育过程。作为潜在的治疗多种神经疾病和卵巢早衰的药物靶标, Gpr3的生理功能及作用的分子机制等都值得进一步研究。文章主要就Gpr3及其介导的信号通路在脊椎动物神经系统发育及卵巢卵泡发育过程中的相关作用作一综述。

关键词: G蛋白偶联受体, Gpr3, 神经系统, 卵泡发育, 减数分裂

Abstract: G protein-coupled receptors (GPCRs), the largest cell surface receptor superfamily, are involved in many physiological and pathological processes. G protein-coupled receptor 3 (Gpr3) is a newly discovered sphingosine 1-phosphate receptor, which directly or indirectly takes part in regulating the processes of nervous system and follicle development in the vertebrates. As a potential therapeutic drug target for a variety of neurological diseases and premature ovarian failure, its physiological function and biological mechanisms deserve further studies. In this paper, we reviewed the functions of Gpr3 in the processes of nervous system development and ovarian follicular development in the vertebrates.

Key words: G protein-coupled receptors, Gpr3, nervous system, follicular development, meiosis

张宝乐高殿帅徐银学. G蛋白偶联受体3：调控神经系统和卵泡发育的关键因子[J]. 遗传, 2013, 35(5): 578-586.

ZHANG Bao-Le GAO Dian-Shuai XU Yin-Xue. G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development[J]. HEREDITAS, 2013, 35(5): 578-586.

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G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development

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