| [1] Daum M, Herrmann S, Wilkinson B, Bechthold A. Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol, 2009, 13(2): 180-188.[2] Kirby J, Keasling JD. Biosynthesis of plant isoprenoids: perspectives for microbial engineering. Annu Rev Plant Biol, 2009, 60(1): 335-355.[3] Ajikumar PK, Tyo K, Carlsen S, Mucha O, Phon TH, Stephanopoulos G. Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microor-ganisms. Mol Pharm, 2008, 5(2): 167-190.[4] Walsh CT, Fischbach MA. Natural products version 2.0: connecting genes to molecules. J Am Chem Soc, 2010, 132(8): 2469-2493.[5] Muntendam R, Melillo E, Ryden A, Kayser O. Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts. Appl Microbiol Biotechnol, 2009, 84(6): 1003-1019.[6] Komatsu M, Tsuda M, ōmura S, Oikawa H, Ikeda H. Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. Proc Natl Acad Sci USA, 2008, 105(21): 7422-7427.[7] Brown GD. The biosynthesis of steroids and triterpenoids. Nat Prod Rep, 1998, 15(6): 653-696.[8] Cane DE, Rosshi T, Pachlatko JP. The biosynthesis of pentalenolactone. Tetrahedron Lett, 1979, 20(38): 3639-3642.[9] Tamamura T, Sawa T, Isshiki K, Masuda T, Homma Y, Inuma H, Naganawa H, Hamada M, Takeuchi T, Umezawa H. Isolation and characterization of terpentecin, a new antitumor antibiotic. J Antibiot, 1985, 38(12): 1664-1669.[10] Shiomi K, Nakamura H, Iinuma H, Naganawa H, Isshiki K, Takeuchi T, Umezawa H, Iitaka Y. Structures of new anti-biotics napyradiomycins. J Antibiot, 1986, 39(4): 494-501.[11] Nakanishi S, Osawa K, Saito Y, Kawamoto I, Kuroda K, Kase H. KS-505a, a novel inhibitor of bovine brain Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase from Streptomyces argenteolus. J Antibiot, 1992, 45(3): 341-347. [12] Komiyama K, Funayama S, Anraku Y, Ishibashi M, Takahashi Y, Omura S. Novel antibiotic, furaquinocins A and B. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics. J Antibiot, 1990, 43(3): 247-252.[13] Torigoe K, Wakasugi N, Sakaizumi N, Ikejima T, Suzuki H, Kojiri K, Suda H. BE-40644, a new human thioredoxin system inhibitor isolated from Actinoplanes sp. A40644. J Antibiot, 1996, 49(3): 314-317.[14] Komaki H, Nemoto A, Tanaka Y, Takagi H, Yazawa K, Mikami Y, Shigemori H, Kobayashi J, Ando A, Nagata Y. Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isola-tion and biological activity. J Antibiot, 1996, 52(1): 13-19.[15] Dairi T. Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes. J Antibiot, 2005, 58(4): 227-243.[16] Dairi T, Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H. Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. J Bacteriol, 2001, 183(20): 6085-6094.[17] Kawasaki T, Kuzuyama T, Furihata K, Itoh N, Seto H, Dairi T. A relationship between the mevalonate pathway and isoprenoid production in actinomycetes. J Antibiot, 2003, 56(11): 957-966.[18] Kawasaki T, Hayashi Y, Kuzuyama T, Furihata K, Itoh N, Seto H, Dairi T. Biosynthesis of a natural polyketide-iso-prenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. J Bacteriol, 2006, 188(4): 1236-1244.[19] Winter JM, Moffitt MC, Zazopoulos E, McAlpine JB, Dorrestein PC, Moore BS. Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin bio-synthetic gene cluster. J Biol Chem, 2007, 282(22): 16362-16368.[20] Bringmann G, Haagen Y, Gulder TAM, Gulder T, Hei |
