Hippo信号通路在肠道稳态、再生及癌变过程中的作用及机制

doi:10.16288/j.yczz.17-048

遗传 ›› 2017, Vol. 39 ›› Issue (7): 588-596.doi: 10.16288/j.yczz.17-048

Hippo信号通路在肠道稳态、再生及癌变过程中的作用及机制

顾远¹(),张雷²,余发星¹()

1. 复旦大学附属儿科医院暨生物医学研究院,上海 200032
2. 中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海 200031

收稿日期:2017-02-17 修回日期:2017-04-10 出版日期:2017-07-20 发布日期:2017-05-23
作者简介:顾远,临床医学八年制,专业方向：临床医学。E-mail: yuangu14@fudan.edu.cn|余发星,研究员,博士生导师,研究方向：细胞生物学。E-mail: fxyu@fudan.edu.cn
基金资助:
国家自然科学基金面上项目(81622038,31571479)

Functions and regulations of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis

Gu Yuan¹(),Zhang Lei²,Yu Faxing¹(),

1. Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
2. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Received:2017-02-17 Revised:2017-04-10 Online:2017-07-20 Published:2017-05-23
Supported by:
the National Natural Science Foundation of China(81622038,31571479)

摘要/Abstract

摘要：

肠道是人体最重要的消化器官之一,急慢性肠炎、肠道肿瘤等肠道疾病严重威胁着人类的健康,因此对肠道生理及病理机制的研究具有重要的科学意义及临床价值。Hippo信号通路在细胞增殖与分化、组织损伤再生、肿瘤发生和发展过程中起重要作用,参与肠道中众多生理及病理进程的调控。本文结合近年来肠道相关Hippo信号通路的研究进展,对该领域的前沿信息进行概括总结,重点阐述了Hippo信号在肠稳态、再生与癌变过程中的作用,并在此基础上展望了肠道中Hippo信号通路研究的前景及潜在的临床价值。

关键词: 肠道, Hippo信号通路, YAP, 再生, 大肠癌

Abstract:

The intestine is an important digestive organ. Intestinal diseases such as acute or chronic enteritis and colorectal cancer pose a great threat to human health, which endows the studies related to intestine with great scientific and clinical value. The Hippo signaling pathway plays an important role in proliferation and differentiation of intestinal stem cells, and is involved in diverse physiological and pathological processes in the intestine. In this review, we summarize known functions and mechanisms of the Hippo signaling pathway in intestinal regeneration and tumorigenesis, provide a prospective on future research directions, and discuss potential therapeutic strategies targeting the Hippo signaling pathway.

Key words: intestine, Hippo signaling pathway, YAP, regeneration, colorectal cancer

顾远, 张雷, 余发星. Hippo信号通路在肠道稳态、再生及癌变过程中的作用及机制[J]. 遗传, 2017, 39(7): 588-596.

Gu Yuan, Zhang Lei, Yu Faxing. Functions and regulations of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis[J]. Hereditas(Beijing), 2017, 39(7): 588-596.

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Hippo信号通路在肠道稳态、再生及癌变过程中的作用及机制

Functions and regulations of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis

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