Hippo信号通路调控免疫细胞的功能

doi:10.16288/j.yczz.17-083

遗传 ›› 2017, Vol. 39 ›› Issue (7): 650-658.doi: 10.16288/j.yczz.17-083

Hippo信号通路调控免疫细胞的功能

余淑娟(),耿晶(),陈兰芬()

厦门大学生命科学学院,厦门 361102

收稿日期:2017-03-09 修回日期:2017-04-07 出版日期:2017-07-20 发布日期:2017-06-28
作者简介:余淑娟,博士研究生,研究方向：免疫学。E-mail: shujuanyu24@126.com|耿晶,博士,博士后,研究方向：免疫学。E-mail: jgeng18@foxmail.com|陈兰芬,教授,博士生导师,研究方向：免疫学。E-mail: chenlanfen@xmu.edu.cn
基金资助:
国家重点基础研究发展规划(973计划)项目(2017YFA0504502,2015CB910502);国家自然科学基金项目(81422018,U1405225,81372617,31600698);厦门市重大疾病科研攻关项目(3502Z20149029)

The functions of the Hippo signaling pathway in immune cells

Shujuan Yu(),Jing Geng(),Lanfen Chen()

School of Life Sciences, Xiamen University, Xiamen 361102, China

Received:2017-03-09 Revised:2017-04-07 Online:2017-07-20 Published:2017-06-28
Supported by:
the National Basic Research Program of China (973 Program)(2017YFA0504502,2015CB910502);the National Natural Science Foundation of China(81422018,U1405225,81372617,31600698);Major Disease Research Projects of Xiamen(3502Z20149029)

摘要/Abstract

摘要：

Hippo信号通路最初是在果蝇(Drosophila)中被发现的,是在进化上高度保守并能调控器官大小的信号转导通路。在哺乳动物多种组织器官中,Hippo信号通路的关键激酶MST1和MST2(果蝇Hippo激酶的同源分子)通过抑制下游的转录共激活分子YAP(果蝇中为Yorki)的活性来实现对细胞增殖和凋亡的调控。在这些组织器官中条件性敲除Mst1和Mst2或过表达Yap大都会造成细胞过度增殖或肿瘤的发生。近年来,随着研究的不断深入,Hippo信号通路不依赖于YAP的非经典功能也逐渐被发现。其中,Hippo信号通路多个成员在免疫系统中的调控功能逐渐成为该领域的研究热点,特别是在免疫细胞发育分化、机体自身免疫性疾病及应对病毒和细菌入侵等过程中所发挥的调控作用。本文重点阐述了Hippo信号通路在T淋巴细胞中发育、分化、活化和迁移等方面及在部分天然免疫细胞抗感染过程中的功能和调控。

关键词: Hippo信号通路, T淋巴细胞, 天然免疫细胞

Abstract:

The Hippo signaling pathway, first identified in Drosophila, has emerged as a critical regulator for controlling the size of organs. Activation of the Hippo signaling pathway negatively regulates the Yorkie ortholog YAP in multiple organs, important in the regulation of cell proliferation, differentiation, and apoptosis during development. The Serine/Threonine protein kinases MST1 and MST2, mammalian homologs of the Drosophila Hippo kinase, play central roles in the Hippo signaling pathway in mammals. Recent studies reveal that non-canonical Hippo signaling pathways are also involved in the regulation of various other biological processes, particularly the important roles of MST1 and MST2 kinases in immune cell activation, adhesion, migration, growth, and apoptosis. In this review, we summarize the recent advances in understanding the roles of MST1 and MST2 kinases in the regulation of the functions of T lymphocytes and innate immune cells.

Key words: Hippo signaling pathway, T cells, innate immune cells

余淑娟,耿晶,陈兰芬. Hippo信号通路调控免疫细胞的功能[J]. 遗传, 2017, 39(7): 650-658.

Shujuan Yu,Jing Geng,Lanfen Chen. The functions of the Hippo signaling pathway in immune cells[J]. Hereditas(Beijing), 2017, 39(7): 650-658.

参考文献

[1]	Harvey KF, Pfleger CM, Hariharan IK. The drosophila mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell, 2003, 114(4): 457-467.
[2]	Jia JH, Zhang WS, Wang B, Trinko R, Jiang J. The drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev, 2003, 17(20): 2514-2519.
[3]	Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev, 1995, 9(5): 534-546.
[4]	Pantalacci S, Tapon N, Léopold P. The salvador partner hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol, 2003, 5(10): 921-927.
[5]	Udan RS, Kango-Singh M, Nolo R, Tao CY, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol, 2003, 5(10): 914-920.
[6]	Wu SA, Huang JB, Dong JX, Pan DJ. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell, 2003, 114(4): 445-456.
[7]	Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: the drosophila lats gene encodes a putative protein kinase. Development, 1995, 121(4): 1053-1063.
[8]	Creasy CL, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene, 1995, 167(1-2): 303-306.
[9]	Creasy CL, Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem, 1995, 270(37): 21695-21700.
[10]	Tao WF, Zhang S, Turenchalk GS, Stewart RA, St John MAR, Chen WL, Xu T. Human homologue of the drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet, 1999, 21(2): 177-181.
[11]	Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA. Mechanism of activation of ndr (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J Biol Chem, 2004, 279(34): 35228-35235.
[12]	Tapon N, Harvey KF, Bell DW, Wahrer DCR, Schiripo TA, Haber DA, Hariharan IK. salvador promotes both cell cycle exit and apoptosis in drosophila and is mutated in human cancer cell lines. Cell, 2002, 110(4): 467-478.
[13]	Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the yes proto-oncogene product. Oncogene, 1994, 9(8): 2145-2152.
[14]	Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions w

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

Hippo信号通路调控免疫细胞的功能

The functions of the Hippo signaling pathway in immune cells

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 11

编辑推荐

Metrics