遗传 ›› 2021, Vol. 43 ›› Issue (6): 571-579.doi: 10.16288/j.yczz.21-062
收稿日期:
2021-02-10
修回日期:
2021-05-07
出版日期:
2021-06-20
发布日期:
2021-05-28
通讯作者:
岑山,李晓宇
E-mail:shancen@imb.pumc.edu.cn;xiaoyulik@hotmail.com
作者简介:
寇艳妮,在读硕士研究生,专业方向:LINE-1与肿瘤维持的内在机制研究。E-mail: 基金资助:
Kou Yanni, Cen Shan(), Li Xiaoyu(
)
Received:
2021-02-10
Revised:
2021-05-07
Online:
2021-06-20
Published:
2021-05-28
Contact:
Cen Shan,Li Xiaoyu
E-mail:shancen@imb.pumc.edu.cn;xiaoyulik@hotmail.com
Supported by:
摘要:
长散布元件-1 (long interspersed elements-1, LINE-1)约占人类基因组的17%,是人类基因组中唯一具有自主转座能力的转座子。LINE-1可通过逆转录转座过程插入到新的基因位点上,从而会导致基因组的不稳定。因而机体对LINE-1的复制和转座有着严格的限制,在正常体细胞中几乎检测不到LINE-1的表达。然而,在绝大多数的肿瘤组织或癌组织中LINE-1的表达却普遍存在,提示LINE-1的表达和转座与肿瘤的发生发展密切相关。LINE-1在肿瘤细胞中的差异表达可以作为肿瘤早期诊断的标志物,同时也可作为肿瘤治疗预后评价的重要指标。与此同时,LINE-1作为肿瘤治疗潜在靶点的可行性也在评估和验证中。本文介绍了在临床方面LINE-1作为肿瘤诊断、预后方面的应用,以及作为肿瘤治疗潜在靶点的研究进展,以期为临床上肿瘤的诊断和治疗提供一些参考。
寇艳妮, 岑山, 李晓宇. LINE-1在肿瘤早期诊断和治疗中的研究与应用[J]. 遗传, 2021, 43(6): 571-579.
Kou Yanni, Cen Shan, Li Xiaoyu. Research and application on LINE-1 in diagnosis and treatment of tumorigenesis[J]. Hereditas(Beijing), 2021, 43(6): 571-579.
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