LINE-1在肿瘤早期诊断和治疗中的研究与应用

doi:10.16288/j.yczz.21-062

遗传 ›› 2021, Vol. 43 ›› Issue (6): 571-579.doi: 10.16288/j.yczz.21-062

LINE-1在肿瘤早期诊断和治疗中的研究与应用

寇艳妮, 岑山(), 李晓宇()

中国医学科学院&北京协和医学院,医药生物技术研究所免疫生物学室,北京 100050

收稿日期:2021-02-10 修回日期:2021-05-07 出版日期:2021-06-20 发布日期:2021-05-28
通讯作者: 岑山,李晓宇 E-mail:shancen@imb.pumc.edu.cn;xiaoyulik@hotmail.com
作者简介:寇艳妮,在读硕士研究生,专业方向：LINE-1与肿瘤维持的内在机制研究。E-mail: yanni_1995@126.com
基金资助:
国家科技重大专项编号(2018ZX10301408-004);国家自然科学基金资助编号(31870164)

Research and application on LINE-1 in diagnosis and treatment of tumorigenesis

Kou Yanni, Cen Shan(), Li Xiaoyu()

Department of Immunology, Institute of Medicinal Biotechnology, Chinese academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received:2021-02-10 Revised:2021-05-07 Online:2021-06-20 Published:2021-05-28
Contact: Cen Shan,Li Xiaoyu E-mail:shancen@imb.pumc.edu.cn;xiaoyulik@hotmail.com
Supported by:
Supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China No(2018ZX10301408-004);the National Natural Science Foundation of China No(31870164)

摘要/Abstract

摘要：

长散布元件-1 (long interspersed elements-1, LINE-1)约占人类基因组的17%,是人类基因组中唯一具有自主转座能力的转座子。LINE-1可通过逆转录转座过程插入到新的基因位点上,从而会导致基因组的不稳定。因而机体对LINE-1的复制和转座有着严格的限制,在正常体细胞中几乎检测不到LINE-1的表达。然而,在绝大多数的肿瘤组织或癌组织中LINE-1的表达却普遍存在,提示LINE-1的表达和转座与肿瘤的发生发展密切相关。LINE-1在肿瘤细胞中的差异表达可以作为肿瘤早期诊断的标志物,同时也可作为肿瘤治疗预后评价的重要指标。与此同时,LINE-1作为肿瘤治疗潜在靶点的可行性也在评估和验证中。本文介绍了在临床方面LINE-1作为肿瘤诊断、预后方面的应用,以及作为肿瘤治疗潜在靶点的研究进展,以期为临床上肿瘤的诊断和治疗提供一些参考。

关键词: 长散布元件-1, 肿瘤, 诊断, 治疗, 预后

Abstract:

Long interspersed element-1 (LINE-1), which is the only autonomous retrotransposon in human genome, makes up about 17% of the human genome. For LINE-1 retrotransposition may result in genome instability, it was strictly restricted by organisms, and its expression was therefore barely detected in normal somatic cells. However, the expression of LINE-1 is a common phenomenon in most tumor or cancer tissues, suggesting a close relationship between LINE-1 expression and cancer development. Differentially expressed LINE-1 in cancer tissues can be used as a biomarker for tumor diagnosis and an important indicator of prognosis after cancer therapeutics. Meanwhile, the feasibility of LINE-1 as a potential drug target for tumor treatment has also been evaluating and verifying in clinicals. In this review, we introduce the application of LINE-1 as a biomarker in tumor diagnosis and prognostic, as well as the research progress in LINE-1 as potential drug target for tumor treatment, in order to provide some references for clinical application in cancer treatment.

Key words: long interspersed element-1, tumor, diagnosis, treatment, prognosis

寇艳妮, 岑山, 李晓宇. LINE-1在肿瘤早期诊断和治疗中的研究与应用[J]. 遗传, 2021, 43(6): 571-579.

Kou Yanni, Cen Shan, Li Xiaoyu. Research and application on LINE-1 in diagnosis and treatment of tumorigenesis[J]. Hereditas(Beijing), 2021, 43(6): 571-579.

图/表 2

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LINE-1的异常表征	癌症实例	参考文献
LINE-1启动子低甲基化	结肠癌、卵巢癌、非小细胞肺癌、肝细胞癌、食管鳞状细胞癌、乳腺癌、急性髓性白血病、膀胱癌	[13~20]
LINE-1 RNA 表达	慢性粒细胞白血病、食管腺癌、乳腺癌、卵巢癌	[21~24]
ORF1p表达	乳腺癌、卵巢癌、胰腺癌、食道癌、结肠癌、肺癌、前列腺癌	[23~29]
ORF2p表达	结肠癌、前列腺癌、肺腺癌、乳腺浸润性导管癌	[29~32]

LINE-1在肿瘤早期诊断和治疗中的研究与应用

Research and application on LINE-1 in diagnosis and treatment of tumorigenesis

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