MT1-MMP在肿瘤转移中的研究进展

doi:10.16288/j.yczz.22-213

遗传 ›› 2022, Vol. 44 ›› Issue (9): 745-755.doi: 10.16288/j.yczz.22-213

MT1-MMP在肿瘤转移中的研究进展

郝庆刚¹(), 孙凤桂², 严程浩¹, 孙建伟¹()

1. 云南大学生命科学学院,生命科学研究中心,昆明 650504
2. 山东省寿光市人民医院听力筛查室,寿光 262750

收稿日期:2022-06-22 修回日期:2022-08-01 出版日期:2022-09-20 发布日期:2022-08-15
通讯作者: 孙建伟 E-mail:haoqinggang@yeah.net;jwsun@ynu.edu.cn
作者简介:郝庆刚,在读博士研究生,研究方向：细胞生物学。E-mail: haoqinggang@yeah.net。
基金资助:
云南省应用基础研究基金(编号)(202101AV070002);云南省应用基础研究基金(编号)(2019FY003030);云南省科技计划重大专项编号(202102AA310055);云南大学第十三届研究生科研创新项目(编号)资助(2021Z088)

Progress on the role and mechanism of MT1-MMP in tumor metastasis

Qinggang Hao¹(), Fenggui Sun², Chenghao Yan¹, Jianwei Sun¹()

1. Center for life Sciences, School of life Sciences, Yunnan University, Kunming 650504, China
2. Department of Hearing Screening Room, Shouguang People's Hospital of Shandong Province, Shouguang 262750, China

Received:2022-06-22 Revised:2022-08-01 Online:2022-09-20 Published:2022-08-15
Contact: Sun Jianwei E-mail:haoqinggang@yeah.net;jwsun@ynu.edu.cn
Supported by:
Supported by the Applied Basic Research Foundation of Yunnan Province Nos(202101AV070002);Supported by the Applied Basic Research Foundation of Yunnan Province Nos(2019FY003030);the Major Science and Technique Programs in Yunnan Province No(202102AA310055);the 13th Graduate Scientific Research Innovation Project of Yunnan University No(2021Z088)

摘要/Abstract

摘要：

基质金属蛋白酶(matrix metallopeptidase, MMPs)家族是一类锌依赖性内肽酶,可降解大多数细胞外基质。MT1-MMP是MMPs家族的重要成员,定位在细胞膜上,并在多种肿瘤中高表达。MT1-MMP通过影响细胞外基质重塑、血管生成、脂质代谢、炎症反应等过程促进肿瘤转移。然而,其具体的调控作用机制仍未完全阐明。本文综述了目前MT1-MMP在各系统肿瘤中的最新研究进展,总结并探讨了其在肿瘤中的促转移调控机制,为其在肿瘤领域的深入研究和应用提供借鉴和参考。

关键词: MT1-MMP, 肿瘤, 转移, 转运, 回收

Abstract:

The matrix metallopeptidase family (matrix metallopeptidase, MMPs) is a class of zinc-dependent endopeptidases that can degrade most extracellular matrices. MT1-MMP (membrane type 1 metalloprotease) is an important metallopeptidase, which is located on plasma membrane and highly expressed in most tumors. MT1-MMP promotes cancer metastasis through affecting the extracellular matrix remodeling, angiogenesis, lipid metabolism, and inflammation. However, the mechanisms of MT1-MMP in different tumors have not been fully elucidated. In this review, we summarize the latest progress and the metastasis-promoting regulatory mechanisms of MT1-MMP in different tumors, which will provide references for its in-depth research and application in the field of cancer biology.

Key words: MT1-MMP, tumor, metastasis, trafficking, recycling

郝庆刚, 孙凤桂, 严程浩, 孙建伟. MT1-MMP在肿瘤转移中的研究进展[J]. 遗传, 2022, 44(9): 745-755.

Qinggang Hao, Fenggui Sun, Chenghao Yan, Jianwei Sun. Progress on the role and mechanism of MT1-MMP in tumor metastasis[J]. Hereditas(Beijing), 2022, 44(9): 745-755.

图/表 2

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MT1-MMP在肿瘤转移中的研究进展

Progress on the role and mechanism of MT1-MMP in tumor metastasis

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