遗传 ›› 2013, Vol. 35 ›› Issue (10): 1143-1152.doi: 10.3724/SP.J.1005.2013.01143
• 综述 • 下一篇
汤琳琳1, 刘琼1,2, 步世忠1,2, 徐雷艇1,2, 王钦文1,2, 麦一峰3, 段世伟1,2
收稿日期:2013-04-25
修回日期:2013-07-04
出版日期:2013-10-20
发布日期:2013-10-25
通讯作者:
段世伟, 博士, 研究员, 研究方向：遗传学。
E-mail:duanshiwei@nbu.edu.cn
作者简介:汤琳琳, 硕士研究生, 专业方向：内科学。E-mail: tll318@163.com
基金资助:国家自然科学基金项目(编号：31100919), 浙江省自然科学基金杰出青年项目(编号：LR13H020003), 宁波市科技局/农业与社会发展攻关项目(编号：2012C50032), 宁波市自然科学基金项目(编号：2007A610077, 200701A6304004), 宁波大学重点学科项目(编号：XKL11D2117)和宁波大学王宽诚幸福基金项目资助
TANG Lin-Lin1, LIU Qiong1,2, BU Shi-Zhong1,2, XU Lei-Ting1,2, WANG Qin-Wen1,2, MAI Yi-Feng3, DUAN Shi-Wei1,2
Received:2013-04-25
Revised:2013-07-04
Online:2013-10-20
Published:2013-10-25
摘要：
2 型糖尿病(Type 2 diabetes mellitus, T2DM)是由于遗传与环境因素共同作用而引起葡萄糖代谢紊乱的疾病。DNA甲基化修饰的研究发现环境因素可以通过影响DNA甲基化修饰, 显著地增加T2DM的患病风险。目前, T2DM环境相关基因的DNA甲基化修饰研究已在人及动物的不同组织中取得进展。此外, T2DM相关基因的甲基化研究主要集中在糖代谢、能量代谢、炎症等。文章系统地综述了目前T2DM致病环境因素与DNA甲基化研究进展。
汤琳琳 刘琼 步世忠 徐雷艇 王钦文 麦一峰 段世伟. 2型糖尿病环境因素与DNA甲基化的研究进展[J]. 遗传, 2013, 35(10): 1143-1152.
TANG Lin-Lin LIU Qiong BU Shi-Zhong XU Lei-Ting WANG Qin-Wen MAI Yi-Feng DUAN Shi-Wei. The effect of environmental factors and DNA methylation on type 2 diabetes mellitus[J]. HEREDITAS, 2013, 35(10): 1143-1152.
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