抗流感病毒小RNAs研究进展

doi:10.3724/SP.J.1005.2012.00526

遗传 ›› 2012, Vol. 34 ›› Issue (5): 526-532.doi: 10.3724/SP.J.1005.2012.00526

抗流感病毒小RNAs研究进展

郑维豪, 林志强, 卓敏, 杜红丽, 王小宁

华南理工大学生物科学与工程学院, 广州 510006

收稿日期:2011-09-01 修回日期:2011-11-16 出版日期:2012-05-20 发布日期:2012-05-25
通讯作者: 杜红丽 E-mail:hldu@scut.edu.cn
基金资助:
十二五“重大新药创制”专项项目(编号: 2011ZX09307-303-03), 广东省科技计划项目（编号: 2010B060200007）和国家大学生创新性实验计划项目(编号: 091056153)资助

Research progress on influenza antiviral small RNAs

ZHENG Wei-Hao, LIN Zhi-Qiang, ZHUO Min, DU Hong-Li, WANG Xiao-Ning

School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China

Received:2011-09-01 Revised:2011-11-16 Online:2012-05-20 Published:2012-05-25
Contact: Hongli Du E-mail:hldu@scut.edu.cn

摘要/Abstract

摘要： 流行性感冒是一类由流感病毒引起的呼吸道传染病, 通过季节性流行或全球性爆发严重威胁着人类健康。目前防治流感的主要方法是疫苗和药物, 但存在神经毒性、肠胃副作用、易耐药等诸多限制因素。新的技术特别是小RNAs介导的RNA干扰(RNAi)技术, 因其具有高效、特异、快速等特点, 已成为抗病毒治疗的候选方法之一。随着近年来流感病毒的流行, 应用小RNAs抗流感病毒的报导越来越多, 其中靶向PA、NP和M2的PA-2087, NP-1496和M-950是目前报道的抑制流感病毒效果最好的siRNA。靶向不同流感病毒基因保守区域的siRNA具有更广泛的病毒毒株抑制效果, 靶向不同基因的siRNAs联合使用可取得更好的病毒抑制效果。文章就目前siRNAs和miRNAs在抗流感病毒方面的研究进展及RNAi治疗的前景和问题进行了综述。

关键词: 流感病毒, 小RNAs, siRNAs, miRNAs, RNAi

Abstract: Worldwide influenza caused by influenza virus is a respiratory disease which threats the public health by seasonal epidemics or global influenza outbreak. Vaccines and drugs are current therapies, but there are many restricted factors such as neurotoxicity, side effects of gastrointestinal, and drug resistance. New technologies, particularly RNAi mediated by small RNAs, has become a potential and robust method in influenza antiviral research for its high efficiency, specific, and speedy. Following the spread and epidemic of the influenza virus, application of small RNAs into influenza antiviral research has been reported increasingly. The small RNAs, PA-2087, NP-1496, and M-950, which targets PA, NP, and M2 genes, respectively, are the most effective anti-influenza siRNAs up to now. siRNA of targeting conservative region of different influenza viral genes has broader effect on virus inhibition. The combination of siRNAs of targeting different genes can achieve better virus inhibition. In this review, we mainly described the progress of siRNAs and miRNAs for anti-influenza virus, and the prospects and hurdles of influenza RNAi therapy as well.

Key words: influenza virus, small RNAs, siRNAs, miRNAs, RNAi

郑维豪，林志强，卓敏，杜红丽，王小宁. 抗流感病毒小RNAs研究进展[J]. 遗传, 2012, 34(5): 526-532.

ZHENG Wei-Hao, LIN Zhi-Qiang, ZHUO Min, DU Hong-Li, WANG Xiao-Ning. Research progress on influenza antiviral small RNAs[J]. HEREDITAS, 2012, 34(5): 526-532.

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抗流感病毒小RNAs研究进展

Research progress on influenza antiviral small RNAs

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