植物非编码RNA调控春化作用的表观遗传

doi:10.3724/SP.J.1005.2012.00829

遗传 ›› 2012, Vol. 34 ›› Issue (7): 829-834.doi: 10.3724/SP.J.1005.2012.00829

植物非编码RNA调控春化作用的表观遗传

张绍峰, 李晓荣, 孙传宝, 何玉科

中国科学院上海生命科学研究院植物生理生态研究所, 植物分子遗传国家重点实验室, 上海200032

收稿日期:2011-12-13 修回日期:2012-02-02 出版日期:2012-07-20 发布日期:2012-07-25
通讯作者: 何玉科 E-mail:ykhe@sibs.ac.cn
基金资助:
国家自然科学基金重点项目(编号：30730053)和上海市科委基础重点项目(编号, 09JC1416000)资助

Epigenetics of plant vernalization regulated by non-coding RNAs

ZHANG Shao-Feng, LI Xiao-Rong, SUN Chuan-Bao, HE Yu-Ke

State Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology & Ecology, Shanghai Institutes for Biologi-cal Sciences, Chinese Academy of Sciences, Shanghai 200032, China

Received:2011-12-13 Revised:2012-02-02 Online:2012-07-20 Published:2012-07-25

摘要/Abstract

摘要： 在自然界中许多高等植物需要通过冬季的低温阶段实现从营养生长到生殖生长的时期转化, 这一生物学过程称作春化作用。小麦(Triticum aestivum L.)和油菜(Brassica napus L.)等作物以种子为产品器官, 生产上往往通过茬口安排和栽培措施使植株尽早通过春化作用, 以促进花芽形成和花器官发育, 而大白菜 (B rapa ssp. pekinenesis)和甘蓝(B. oleracea)等作物以叶球等营养器官作为产品器官, 生产上则设法避免低温引起的春化作用, 以保证产品器官的充分生长。FLOWERING LOCUS C(FLC)作为一种重要的开花抑制蛋白负调控春化作用, 参与植株从营养生长向生殖生长的转化过程。文章综述了春化中FLC表达受抑制主要通过低温诱导表达FLC基因区域的非编码RNA以及VRN1、VRN2、VIN3等蛋白参与介导组蛋白甲基化, 从而在表观遗传上控制春化作用的进程和产品器官的正常发育。

关键词: 表观遗传, 春化作用, FLC, 非编码RNA, 天然反向转录本

Abstract: Many higher plants must experience a period of winter cold to accomplish the transition from vegetative to reproductive growth. This biological process is called vernalization. Some crops such as wheat (Triticum aestivum L.) and oilseed rape (Brassica napus L.) produce seeds as edible organs, and therefore special measures of rotation and cultivation are necessary for plants to go through an early vernalization for flower differentiation and development, whereas the other crops such as Chinese cabbage (B rapa ssp. pekinenesis) and cabbage (Brassica napus L.) produce leafy heads as edible organs, and additional practice should be taken to avoid vernalization for a prolonged and fully vegetative growth. Before vernalization, flowering is repressed by the action of a gene called Flowering Locus C (FLC). This paper reviewed the function of non-coding RNAs and some proteins including VRN1, VRN2, and VIN3 in epigenetic regulation of FLC during vernalization.

Key words: epigenetics, vernalization, non-coding RNA, natural antisense transcripts, FLC

张绍峰，李晓荣，孙传宝，何玉科. 植物非编码RNA调控春化作用的表观遗传[J]. 遗传, 2012, 34(7): 829-834.

ZHANG Shao-Feng, LI Xiao-Rong, SUN Chuan-Bao, HE Yu-Ke. Epigenetics of plant vernalization regulated by non-coding RNAs[J]. HEREDITAS, 2012, 34(7): 829-834.

参考文献

[1] Swiezewski S, Crevillen P, Liu F, Ecker JR, Jerzmanowski A, Dean C. Small RNA-mediated chromatin silencing directed to the 3′ region of the Arabidopsis gene encoding the developmental regulator, FLC. Proc Natl Acad Sci USA, 2007, 104(9): 3633-3638.
[2] Groszmann M, Greaves IK, Albert N, Fujimoto R, Helli-well CA, Dennis ES, Peacock WJ. Epigenetics in plants-vernalization and hybrid. Biochim Biophys Acta, 2011, 1809(8): 427-437.
[3] Kole C, Quijada P, Michaels SD, Amasino RM, Osborn TC. Evidence for homology of flowering-time genes VFR2 from Brassica rapa and FLC from Arabidopsis thaliana. Theor Appl Genet, 2001, 102(2-3): 425-430.
[4] Schranz ME, Quijada P, Sung S,B, Lukens L, Amasino R, Osborn TC. Characterization and effects of the replicated flowering time gene FLC in Brassica rapa. Genetics, 2002, 162(3): 1457-1468.
[5] Kim SY, Michaels SD. SUPPRESSOR OF FRI 4 encodes a nuclear-localized protein that is required for delayed flowering in winter-annual Arabidopsis. Development, 2006, 133(23): 4699-4707.
[6] Yang TJ, Kim JS, Kwon SJ, Lim KB, Choi BS, Kim JA, Jin M, Park JY, Lim MH, Kim HI, Lim YP, Kang JJ, Hong JH, Kim CB, Bhak J, Bancroft I, Park BS. Sequence-level analysis of the diploidization process in the triplicated FLOWERING LOCUS C region of Brassica rapa. Plant Cell, 2006, 18(6): 1339-1347.
[7] Lin SI, Wang JG, Poon SY, Su CL, Wang SS, Chiou TJ. Differential regulation of FLOWERING LOCUS C expression by vernalization in cabbage and Arabidopsis. Plant Physiol, 2005, 137(3): 1037-1048.
[8] Kim SY, Park BS, Kwon SJ, Kim J, Lim MH, Park YD, Kim DY, Suh SC, Jin YM, Ahn JH, Lee YH. Delayed flowering time in Arabidopsis and Brassica rapa by the overexpression of FLOWERING LOCUS C (FLC) homologs isolated from Chinese cabbage (Brassica rapa L. ssp. pekinensis). Plant Cell Rep, 2007, 26(3): 327-336.
[9] Bastow R, Mylne JS, Lister C, Lippman Z, Martienssen RA, Dean C. Vernalization requires epigenetic silencing of FLC by histone methylation. Nature, 2004, 427(6970): 164-167.
[10] Sung S, He Y, Eshoo TW, Tamada Y, Johnson L, Nakahigashi K, Goto K, Jacobsen SE, Amasino RM. Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1. Nat Genet, 2006, 38(6): 706-710.
[11] Swiezewski S, Liu F, Magusin A, Dean C. Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target. Nature, 2009, 462(10): 799-802.
[12] Heo JB, Sung S. Vernalization-mediated epigenetic silencing by a long intronic noncoding RNA. Science, 2011, 331(6013): 76-79.
[13] Turck F, Coupland G. When vernalization makes sense. Science, 2011, 331(6013): 36-37.
[14] Rank G, Prestel M, Paro R. Transcription through intergenic chromosomal memory elements of the Drosophila bithorax complex correlates with an epigenetic switch. Mol Cell Biol, 2002, 22(22): 8026-8034.
[15] Schmitt S Prestel M, Paro R. Intergenic transcription through a polycomb group response element counteracts silencing. Genes Dev, 2005, 19(6): 697-708.
[16] Lavorgna G, Dahary D, Lehner B, Sorek R, Sanderson CM, Casari G. In search of antisense. Trends Biochem Sci, 2004, 29(2): 88-94.
[17] Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD. Genome-wide RNAi screen of Ca²⁺ influx identifies genes that regulate Ca(2+) release-activated Ca²⁺ channel activity. Proc Natl Acad Sci USA, 2006, 103(24): 9357-9362.
[18] Yelin R, Dahary D, Sorek R, Levanon EY, Goldstein O, Shoshan A, Diber A, Biton S, Tamir Y, Khosravi R, Nemzer S, Pinner E, Walach S, Bernstein J, Savitsky K, Rotman G. Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol, 2003, 21: 379-386.
[19] Sleutels F, Zwart R, Barlow DP. The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature, 2002, 415(6873): 810-813.
[20] Thakur N, Tiwari VK, Thomassin H, Pandey RR, Kanduri M, Gondor A, Grange T, Ohlsson R, Kanduri C. An antisense RNA regulates the bidirectional silencing property of the kcnq1 imprinting control region. Mol Cell Biol, 2004, 24(18): 7855-7862.
[21] Vacic V, Jin H, Zhu JK, Lonardi S. A probabilistic method for small RNA flowgram matching. Pac Symp Biocomput, 2008: 75-86.
[22] Liu FQ, Marquardt S, Lister C, Swiezewski S, Dean C. Targeted 3. Processing of antisense transcripts triggers Arabidopsis FLC chromatin silencing. Science, 2010, 327(5961): 94-97.
[23] Camblong J, Iglesias N, Fickentscher C, Dieppois G, Stutz F. Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae. Cell, 2007, 131(4): 706-717.
[24] Sheldon CC, Rouse DT, Finnegan EJ, Peacock WJ, Dennis ES. The molecular basis of vernalization: the central role of FLOWERING LOCUS C (FLC). Proc Natl Acad Sci USA, 2000, 97(7): 3753-3758.
[25] Swiezewski S, Crevillen P, Liu F, Ecker JR, Jerzmanowski A, Dean C. Small RNA-mediated chromatin silencing directed to the 3' region of the Arabidopsis gene encoding the developmental regulator, FLC. Proc Natl Acad Sci USA, 2007, 104(9): 3633-3638.
[26] Bushey AM, Dorman ER, Corces VG. Chromatin insulators: regulatory mechanisms and epigenetic inheritance. Mol Cell, 2008, 32(1): 1-9.
[27] Sheldon CC, Hills MJ, Lister C, Dean C, Dennis ES. Peacock, W. J. Resetting of FLOWERING LOCUS C expression after epigenetic repression by vernalization. Proc Natl Acad Sci USA, 2008, 105(6): 2214-2219.
[28] Alvarez-Buylla ER, Liljegren SJ, Pelaz S, Gold SE, Burgeff C, Ditta GS, Vergara-Silva F, Yanofsky MF. MADS- box gene evolution beyond flowers: expression in pollen, endosperm, guard cells, roots and trichomes. Plant J, 2000, 24(4): 457-466.
[29] Becker A, Theissen G. The major clades of MADS-box genes and their role in the development and evolution of flowering plants. Mol Phylogenet Evol, 2003, 29(3): 464-489.
[30] Ratcliffe OJ, Nadzan GC, Reuber TL, Riechmann JL. Regulation of flowering in Arabidopsis by an FLC homelogue. Plant Physiol, 2001, 126(1): 122-132.
[31] Yu H, Ito T, Wellmer F, Meyerowitz EM. Repression of AGAMOUS-LIKE 24 is a crucial step in promoting flower development. Nat Genet, 2004, 36(2): 157-161.
[32] Gregis V, Sessa A, Colombo L, Kater MM. AGL24, SHORT VEGETATIVE PHASE, and APETALA1 redundantly control AGAMOUS during early stages of flower development in Arabidopsis. Plant Cell, 2006, 18(6): 1373-1382.
[33] Schönrock N, Bouveret R, Leroy O, Borghi L, Köhler C, Gruissem W, Hennig L. Polycomb-group proteins repress the floral activator AGL19 in the FLC-independent vernalization pathway. Genes Dev, 2006, 20(12): 1667-1678.
[34] Schranz ME, Quijada P, Sung SB, Lukens L, Amasino R, Osborn TC. Characterization and effects of the replicated flowering time gene FLC in Brassica rapa. Genetics, 2002, 162(3): 1457-1468.

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

植物非编码RNA调控春化作用的表观遗传

Epigenetics of plant vernalization regulated by non-coding RNAs

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	刘传明,丁利军,李佳音,戴建武,孙海翔. 衰老导致卵巢功能低下研究进展[J]. 遗传, 2019, 41(9): 816-826.
[2]	张競文,续倩,李国亮. 癌症发生发展中的表观遗传学研究[J]. 遗传, 2019, 41(7): 567-581.
[3]	马志鹏, 陈军. 无义突变与“遗传补偿效应”[J]. 遗传, 2019, 41(5): 359-364.
[4]	张华伟, 孟星宇, 李连峰, 杨玉莹, 仇华吉. 长链非编码RNA——抗病毒天然免疫应答的新兴调控因子[J]. 遗传, 2018, 40(7): 525-533.
[5]	周瑞,王以鑫,龙科任,蒋岸岸,金龙. LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展[J]. 遗传, 2018, 40(4): 292-304.
[6]	朱亚男, 敖英, 李斌, 万阳, 汪晖. 足细胞发育异常及相关肾脏疾病研究进展[J]. 遗传, 2018, 40(2): 116-125.
[7]	李恩惠,赵欣,张策,刘威. 脆性X智力低下蛋白参与非编码RNA通路的研究进展[J]. 遗传, 2018, 40(2): 87-94.
[8]	黎伟, 秦俊, 汪晖, 陈廖斌. 表观遗传生物标志物在人类疾病早期诊治中的研究进展[J]. 遗传, 2018, 40(2): 104-115.
[9]	王天工, 叶孟. m ⁶A甲基化与肿瘤研究进展[J]. 遗传, 2018, 40(12): 1055-1065.
[10]	柯玉文,刘江. 动物早期胚胎发育中染色质结构的继承和重编程[J]. 遗传, 2018, 40(11): 977-987.
[11]	叶仲杰,刘启鹏,岑山,李晓宇. LINE-1编码的逆转录酶在肿瘤形成过程中的作用[J]. 遗传, 2017, 39(5): 368-376.
[12]	刘福林, 周瑾, 张蔚, 汪晖. 胎盘发育过程中的表观遗传学改变及其相关疾病[J]. 遗传, 2017, 39(4): 263-275.
[13]	陈青云,李有志,樊宪伟. 植物气孔发育的分子调控机制[J]. 遗传, 2017, 39(4): 302-312.
[14]	王建, 张凯翔, 芦国珍, 赵湘辉. 5-羟甲基胞嘧啶及其TET氧合酶在神经系统发育和相关疾病中的研究进展[J]. 遗传, 2017, 39(12): 1138-1149.
[15]	岳敏, 杨禹, 郭改丽, 秦曦明. 哺乳动物生物钟的遗传和表观遗传研究进展[J]. 遗传, 2017, 39(12): 1122-1137.