遗传 ›› 2014, Vol. 36 ›› Issue (2): 95-102.doi: 10.3724/SP.J.1005.2014.0095
• 综述 • 下一篇
许飞1, 张进1, 马端1,2
收稿日期:2013-08-26
修回日期:2013-11-25
出版日期:2014-02-20
发布日期:2014-01-25
通讯作者:
张进, 博士, 讲师, 研究方向：遗传相关疾病的发病机制。E-mail: zhangjin@rocketmail.com
马端, 博士, 教授, 博士生导师, 研究方向：遗传相关疾病的发病机制。E-mail: duanma@fudan.edu.cn
E-mail:zhangjin@rocketmail.com
作者简介:许飞, 直博生, 研究方向：肿瘤信号通路。E-mail：dashing1988@163.com
基金资助:高等学校博士学科点专项科研基金(新教师类课题)(编号：20110071120033)资助
Fei Xu1, Jin Zhang1, Duan Ma1,2
Received:2013-08-26
Revised:2013-11-25
Online:2014-02-20
Published:2014-01-25
摘要：
Hippo/YAP通路和Wnt/β-catenin通路是在细胞的生长分化、组织器官形成以及成体干细胞的维持等方面都起着重要作用的两条信号通路。在哺乳动物细胞中, Wnt/β-catenin通路通过一系列胞质蛋白的相互作用, 使β-catenin蛋白在胞质内累积, 进而入核传递生长刺激信号。Hippo/YAP通路通过激酶级联反应磷酸化YAP/TAZ, 使其滞留在细胞质中, 抑制了YAP/TAZ的转录活性, 从而限制细胞的生长增殖, 诱导细胞凋亡。这两条通路的异常调控往往会导致肿瘤的发生。近年来越来越多的研究证实, Hippo/YAP 和Wnt/β-catenin在很多方面相互影响, 共同参与组织生长和胚胎发育的调控。研究这两个通路在肿瘤发生过程中的转导和调控以及它们相互作用的机制, 有助于为肿瘤的防治提供新的思路与策略。文章对这两条通路的协同作用及其分子机制进行了综述。
许飞, 张进, 马端. Hippo/YAP和Wnt/β-catenin通路的对话[J]. 遗传, 2014, 36(2): 95-102.
Fei Xu, Jin Zhang, Duan Ma. Crosstalk of Hippo/YAP and Wnt/β-catenin pathways[J]. HEREDITAS, 2014, 36(2): 95-102.
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