遗传 ›› 1995, Vol. 17 ›› Issue (3): 13-15.

• 论文 • 上一篇    下一篇

中国人α珠蛋白基因3’HVR多态分布的研究

鲁晓宣; 茅一萍; 张军; 李明发; 高翼之; 王世浚 LU Xiao-Xuan;MAO Yi-Ping;ZHANG Jun;LI Ming-Fa;GAO Yi-Zhi;WANG Shi-Jun   

  1. 南京铁道医学院生物学教研室, 南京 210009 Departmnet of Biology,Nanjing Railway Medical College,Nanjing 210009
  • 收稿日期:1900-01-01 出版日期:1995-06-10 发布日期:1995-06-10

Restriction Fragment Length Polymorphism of alpha-Globin 3’HVR Locus in Chinese Population

  • Received:1900-01-01 Online:1995-06-10 Published:1995-06-10

摘要: 本文以3’HVR为探针,对来自全国17省市的51名无血缘关系的健康人进行P vuⅡ限制性片段长度的多态分析,发现3’HVR在片段大小的变异范围及基因频率的分布均有中国人的特点。结果表明,纯合子占15.7%,杂合子占84 .3%,102个等位基因共有34个长度不同的等位片段,大小从2.0-7.0kb之间呈连续分布, 主要分布在2.0-2.5kb及4.0-6.0kb,频率分别为0.43和0.34。并与刘国仰、余裕炉等的资料进行综合比较,初步揭示了中国人群中3’HVR的多态特点。
Abstract: 51 unrelated Chinese individuals from 17 different provinces and cities were typed for PvuII restiction fragment length polymorphism with the probe 3’HVR.The frequencies of homozygotes and heterozygotes were estimated as 15.7% and 84.3%,34 distinguishable allele sizes showed a continue distribution from 2.0-7.0kb.The main alleles of 2.0-2.5kb and 4.0-6.0kb gave the gene frequencies of 0.43 and 0.34 respectively.The preliminary characteristics of 3’HVR locus in Chinese population were revealed.

关键词: 高变区序列, 人α-珠蛋白基因簇
Key words,
限制性片段长度多态性, Hyper variable region, Restriction fragment length polymorphism, 等位酶, 独龙牛, 遗传多样性

Key words: Genetic diverity, Allozyme, Mithun(Bos frontalis)