遗传 ›› 2012, Vol. 34 ›› Issue (11): 1351-1364.doi: 10.3724/SP.J.1005.2012.01351
杨昭庆, 禇嘉祐
收稿日期:2012-10-26
修回日期:2012-11-02
出版日期:2012-11-20
发布日期:2012-11-25
通讯作者:
褚嘉祐
E-mail:chujy@imbcams.com.cn
基金资助:国家高技术研究发展计划(863)项目(编号：2012AA021802)和国家自然科学基金面上项目(编号：30971578)资助
YANG Zhao-Qing, CHU Jia-You
Received:2012-10-26
Revised:2012-11-02
Online:2012-11-20
Published:2012-11-25
Contact:
Jiayou Chu
E-mail:chujy@imbcams.com.cn
摘要： 人类遗传多样性表现为世界各种族、民族和个体间存在的基因组差异, 是探讨人类进化与迁徙、环境与遗传背景相互作用、疾病与健康影响因素的主要资源和工具。中国具有世界1/5的人口, 有56个民族和丰富的遗传多样性资源。经过几十年的努力, 中国人类遗传多样性研究已积累了丰富的资料, 部分成果已经达到国际先进水平。文章重点论述了近年来形态学标记、生化及免疫学标记、DNA遗传标记在我国人类遗传多样性研究中的应用, 线粒体DNA、Y染色体DNA和HLA标记在中国不同民族源流和相互关系、东亚现代人起源和迁移等研究中的应用, 以及我国在中华民族遗传资源保存和利用、疾病易感基因和环境适应相关基因的鉴定及全基因组关联分析和第二代测序技术的应用、中国人基因组结构研究等方面取得的重要成果和进展。
杨昭庆，褚嘉祐. 中国人类遗传多样性研究进展[J]. 遗传, 2012, 34(11): 1351-1364.
YANG Zhao-Qing, CHU Jia-You. The research progress of human genetic diversity in China[J]. HEREDITAS, 2012, 34(11): 1351-1364.
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