MicroRNA参与调控睾丸支持细胞的增殖与粘附功能

doi:10.16288/j.yczz.18-050

遗传 ›› 2018, Vol. 40 ›› Issue (9): 724-732.doi: 10.16288/j.yczz.18-050

MicroRNA参与调控睾丸支持细胞的增殖与粘附功能

夏蒙蒙(),申雪沂,牛长敏,夏静,孙红亚,郑英()

扬州大学医学院组织学与胚胎学教研室,扬州 225001

收稿日期:2018-02-27 修回日期:2018-06-26 出版日期:2018-09-20 发布日期:2018-07-27
作者简介:夏蒙蒙,硕士研究生,专业方向：生殖医学。E-mail: nursingxmm@163.com
基金资助:
国家自然科学基金项目(31371174);江苏省自然科学基金项目(BK20131230)

MicroRNA regulates Sertoli cell proliferation and adhesion

Xia Mengmeng(),Shen Xueyi,Niu Changmin,Xia Jing,Sun Hongya,Zheng Ying()

Department of Histology and Embryology, School of Medicine,Yangzhou University, Yangzhou 225001, China

Received:2018-02-27 Revised:2018-06-26 Online:2018-09-20 Published:2018-07-27
Supported by:
Supported by the National Natural Science Foundation of China(31371174);the Natural Science Foundation of Jiangsu Province(BK20131230)

摘要/Abstract

摘要：

精子发生过程需要生精细胞及睾丸体细胞的共同参与,这两种细胞也决定着睾丸的发育及雄性生育力。支持细胞是生精小管中唯一的体细胞,在正常精子发生过程中发挥重要的作用。支持细胞增殖与粘附功能的异常将导致精子发生异常,进而引发雄性不育。近年来研究发现,microRNA (miRNA)可调控支持细胞的增殖与粘附功能,其表达水平在激素、内分泌干扰素和营养状况等多种因素作用下发生特异性变化。本文总结了与睾丸支持细胞增殖与粘附功能相关的miRNA及其作用机制,以期发现并鉴定更多与支持细胞相关的miRNA,进而为探索与支持细胞相关不育症的病因提供理论依据。

关键词: miRNA, 支持细胞, 增殖, 粘附

Abstract:

Spermatogenesis requires both germ cells and testicular somatic cells, which are also involved in testicular development and male fertility. Sertoli cells are the only somatic cells in the seminiferous tubules and play very important roles in normal spermatogenesis. Abnormality of Sertoli cells in proliferation and adhesion may induce aberrant spermatogenesis and eventually cause infertility. Recently, various studies have demonstrated that miRNA are involved in the regulation of Sertoli cell proliferation and adhesion. Additionally, miRNA expression could be affected by hormone, endocrine interferon, and nutrition. In this review, we summarize miRNAs related to Sertoli cell proliferation and adhesion, which will be helpful for finding and identifying more miRNAs from Sertoli cells. The review will also provide theoretical basis for the pathogenesis of infertility associated with Sertoli cells.

Key words: miRNA, Sertoli cells, proliferation, adhension

夏蒙蒙,申雪沂,牛长敏,夏静,孙红亚,郑英. MicroRNA参与调控睾丸支持细胞的增殖与粘附功能[J]. 遗传, 2018, 40(9): 724-732.

Xia Mengmeng,Shen Xueyi,Niu Changmin,Xia Jing,Sun Hongya,Zheng Ying. MicroRNA regulates Sertoli cell proliferation and adhesion[J]. Hereditas(Beijing), 2018, 40(9): 724-732.

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MicroRNA参与调控睾丸支持细胞的增殖与粘附功能

MicroRNA regulates Sertoli cell proliferation and adhesion

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