遗传 ›› 2018, Vol. 40 ›› Issue (10): 825-840.doi: 10.16288/j.yczz.18-209

• 综述 • 上一篇    下一篇

中国细胞重编程和多能干细胞研究进展

康岚2,3(),陈嘉瑜1,2(),高绍荣1,2()   

  1. 1. 同济大学附属第一妇婴保健院转化医学中心,上海 201104
    2. 同济大学生命科学与技术学院,上海 200092
    3. 同济大学附属东方医院再生医学研究所,上海 200123
  • 收稿日期:2018-07-20 修回日期:2018-08-30 出版日期:2018-10-20 发布日期:2018-09-11
  • 作者简介:康岚,教授,研究方向：干细胞与体细胞重编程。E-mail: kanglan@tongji.edu.cn|陈嘉瑜,副教授,研究方向：干细胞与体细胞重编程。E-mail: chenjiayu@tongji.edu.cn
  • 基金资助:
    国家重点研发计划(2016YFA0100400);国家自然科学基金项目(31721003);国家自然科学基金项目(81630035);国家自然科学基金项目(31430056);国家自然科学基金项目(31871489);国家自然科学基金项目(31871446)

Historical review of reprogramming and pluripotent stem cell research in China

Lan Kang2,3(), Jiayu Chen1,2(), Shaorong Gao1,2()   

  1. 1. Center of Translational Medicine, First Maternal and Child Health Care Hospital, Tongji University, Shanghai 201104, China
    2. School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
    3. Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University,Shanghai 200123, China
  • Received:2018-07-20 Revised:2018-08-30 Online:2018-10-20 Published:2018-09-11
  • Supported by:
    the National Key R&D program of China(2016YFA0100400);the National Natural Science Foundation of China(31721003);the National Natural Science Foundation of China(81630035);the National Natural Science Foundation of China(31430056);the National Natural Science Foundation of China(31871489);the National Natural Science Foundation of China(31871446)

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摘要：

近几十年是干细胞领域飞速发展的重要时期。随着中国经济实力的发展壮大,科研实力也在稳步增强,干细胞研究领域达到了国际并跑甚至领跑的水平。本文从体细胞核移植、诱导多能干细胞、单倍体多能干细胞和胚胎早期发育研究4个方面,对中国细胞重编程和干细胞领域的研究进展进行了历史性回顾,总结了中国科学家在相关领域所取得的重要科研成果。随着单细胞测序技术的发展,各种发育过程将实现更为深入的解读,干细胞的临床应用在中国也会大放异彩。

关键词: 重编程, 体细胞核移植, 诱导多能干细胞, 单倍体多能干细胞, 单细胞测序

Abstract:

The research of stem cell field has developed rapidly in recent decades. With the enhancing of China's economic power, the strength of scientific research is steadily increasing, and the stem cell research even has reached international advanced level. Here, we make a historical review of important research in China, focusing on somatic cell nuclear transfer, induced pluripotent stem cells, haploid pluripotent stem cells and early embryo development. The fast development of single cell sequencing will greatly help the understanding of various development process, and the stem cell clinical application will blossom in China in the future.

Key words: reprogramming, somatic cell nuclear transfer, induced pluripotent stem cells, haploid pluripotent stem cells, single cell sequencing