遗传 ›› 2014, Vol. 36 ›› Issue (9): 879-887.doi: 10.3724/SP.J.1005.2014.0879
任才芳，孙红艳，王立中，张国敏，樊懿萱，颜光耀，王丹，王锋
收稿日期:2014-04-17
出版日期:2014-09-20
发布日期:2014-09-20
通讯作者:
王锋，博士，教授，研究方向：动物胚胎工程。E-mail: caeet@njau.edu.cn
E-mail:2012105033@njau.edu.cn
作者简介:任才芳，博士研究生，研究方向：胚胎干细胞。
基金资助:Caifang Ren, Hongyan Sun, Lizhong Wang, Guomin Zhang, Yixuan Fan, Guangyao Yan, Dan Wang, Feng Wang
Received:2014-04-17
Online:2014-09-20
Published:2014-09-20
摘要： 诱导性多能干细胞(Induced pluripotent stem cells, iPSCs)是采用特定转录因子，将体细胞重编程为具有多能性的干细胞。iPSCs已成功由多种体细胞诱导出来，不仅具有发育多能性还能避免胚胎干细胞(Embryonic stem cells, ESCs)的伦理道德问题，已成为生命科学领域不可或缺的研究工具，具有广阔的应用前景。但获得高质量、遗传稳定的iPSCs是当前亟须解决的问题。文章对iPSCs重编程机制和遗传稳定性的研究进展进行了综述，以期为提高iPSCs的诱导效率、降低诱导成本、掌握iPSCs质量控制的关键点提供参考，从而推进多能性干细胞临床应用的发展。
任才芳，孙红艳，王立中，张国敏，樊懿萱，颜光耀，王丹，王锋. iPSCs遗传稳定性与重编程机制的研究进展[J]. 遗传, 2014, 36(9): 879-887.
Caifang Ren, Hongyan Sun, Lizhong Wang, Guomin Zhang, Yixuan Fan, Guangyao Yan, Dan Wang, Feng Wang. Reprogramming mechanism and genetic stability of induced pluripotent stem cells (iPSCs)[J]. HEREDITAS(Beijing), 2014, 36(9): 879-887.
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