遗传

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DNA羟甲基化调控动脉粥样硬化发生发展的研究进展

胡颖楚1,胡豪畅2,林少沂1,陈晓敏1   

  1. 1. 浙江大学宁波医院
    2. 宁波大学医学院
  • 收稿日期:2020-04-23 修回日期:2020-05-28 出版日期:2020-06-01 发布日期:2020-06-01
  • 通讯作者: 陈晓敏
  • 基金资助:
    浙江省自然科学基金项目;宁波市自然科学基金项目

The role of DNA hydroxymethylation in the regulation of atherosclerosis

  • Received:2020-04-23 Revised:2020-05-28 Online:2020-06-01 Published:2020-06-01
  • Contact: Xiaomin -Chen

摘要: DNA羟甲基化作为一种表观遗传学修饰,对基因的表达调控起到了重要作用。近年来,越来越多的研究发现在心血管疾病中可见5-羟甲基胞嘧啶(5-hydroxymethylcytosine, 5hmC)和染色体10/11易位(ten-eleven translocation, TET)家族蛋白的异常改变,提示这些心血管疾病与DNA羟甲基化的调控密切相关。DNA羟甲基化水平与动脉粥样硬化常见的危险因素如衰老、性别、高血压和吸烟存在一定关联,且和动脉粥样硬化发生过程中所涉及的免疫炎症反应以及内皮细胞和血管平滑肌细胞的功能相关。本文综述了DNA羟甲基化和TET家族蛋白对于动脉粥样硬化的作用机制及研究现状,以期为动脉粥样硬化的发生发展及诊断治疗提供表观遗传学方面的研究思路。

关键词: DNA羟甲基化, 动脉粥样硬化, 5hmC, TET, 表观遗传学

Abstract: As an epigenetic modification, DNA hydroxymethylation plays a significant role in regulating gene expression. In recent years, there has been increasing evidence that suggests abnormal changes of 5-hydroxymethylcytosine (5hmC) and ten-eleven translocation (TET) family proteins in cardiovascular diseases, indicating cardiovascular diseases are closely connected with DNA hydroxymethylation. The level of DNA hydroxymethylation is affected by some common risk factors of atherosclerosis, such as aging, gender, hypertension and smoking. It is also related to the immune and inflammatory reaction involved in the process of atherosclerosis as well as the function of endothelial cells and vascular smooth muscle cells. In this review, we summarize the mechanism and research status of DNA hydroxymethylation and TET family proteins towards atherosclerosis, aiming to provide a reference for the development, diagnosis and treatment of atherosclerosis.

Key words: DNA hydroxymethylation, atherosclerosis, 5hmC, TET, epigenetics