蛋白质乙酰化修饰对自噬的调控作用

doi:10.16288/j.yczz.21-329

遗传 ›› 2022, Vol. 44 ›› Issue (1): 15-24.doi: 10.16288/j.yczz.21-329

蛋白质乙酰化修饰对自噬的调控作用

刘静(), 易聪, 许师明()

浙江大学医学院,杭州 310020

收稿日期:2021-09-13 修回日期:2021-12-01 出版日期:2022-01-20 发布日期:2021-12-02
通讯作者: 许师明 E-mail:18428302536@163.com;xusm@e-mdic.cn
作者简介:刘静,在读硕士研究生,专业方向：细胞生物学。E-mail: 18428302536@163.com
基金资助:
国家自然科学基金项目资助编号(31600934)

The regulatory effect of protein acetylation modification on autophagy

Jing Liu(), Cong Yi, Shiming Xu()

School of Medicine, Zhejiang University, Hangzhou 310020, China

Received:2021-09-13 Revised:2021-12-01 Online:2022-01-20 Published:2021-12-02
Contact: Xu Shiming E-mail:18428302536@163.com;xusm@e-mdic.cn
Supported by:
Supported by the National Natural Science Foundation of China No(31600934)

摘要/Abstract

摘要：

自噬是一种依赖于液泡或溶酶体,从酵母到人类都高度保守的物质降解途径,其在维持细胞稳态过程中起重要作用。自噬功能的异常与人类多种重大疾病如神经退行性疾病、代谢性疾病及恶性肿瘤的发生发展密切相关。作为维持生物体内稳态平衡的重要生物学过程,细胞自噬的发生受到精密的调控。乙酰化修饰作为一种可逆的蛋白翻译后修饰(post-translational modification, PTM),在自噬的精密调控中发挥重要作用。本文主要对近年来乙酰化修饰在自噬调控中的相关研究进行了综述,以期为自噬领域的基础研究提供思路,同时也为研究人员探索自噬相关疾病的预防和治疗方法提供参考。

关键词: 自噬, 乙酰化, 自噬相关蛋白

Abstract:

Autophagy is a highly conserved material degradation pathway from yeast to humans that depends on vacuoles or lysosomes. It plays an important role in the maintenance of homeostasis, and its dysfunction is closely related to the pathogenesis of major diseases, such as neurodegenerative disorders, metabolic diseases, and malignant tumors. As an important biological process for the maintenance of homeostasis, autophagy is highly regulated. Acetylation of proteins is a reversible post-translational modification and plays an important role in the regulation of autophagy. In this review, we summarize research results on the modulation of acetylation in the regulation of autophagy and aim to provide insights into this biological process for the advancement of the basic research and development of preventive and therapeutic strategies against autophagy-related diseases.

Key words: autophagy, acetylation, autophagy-related proteins

刘静, 易聪, 许师明. 蛋白质乙酰化修饰对自噬的调控作用[J]. 遗传, 2022, 44(1): 15-24.

Jing Liu, Cong Yi, Shiming Xu. The regulatory effect of protein acetylation modification on autophagy[J]. Hereditas(Beijing), 2022, 44(1): 15-24.

图/表 2

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蛋白	乙酰化位点	乙酰化酶/去乙酰化酶	对自噬的影响	相关文献
ATG12	—	p300/SIRT1	ATG12乙酰化抑制自噬发生	[29,39]
ATG9A	K359、K363	—/SIRT1	ATG9A的去乙酰不仅影响自噬体膜的形成,也充当内质网(ER)压力诱导自噬的传感器	[40,41]
LC3	K49、K51	p300/SIRT1	去乙酰化的LC3转位到胞质内,参与自噬复合体的形成	[42,43]
VPS34	K29、K771	p300/SIRT1	p300依赖性乙酰化/去乙酰化是诱导VPS34激酶活化并参与自噬的关键	[44]
ULK1	K162、K606	TIP60/—	ULK1的乙酰化是生长因子缺乏诱导的自噬所必需的	[45]
ATG5	—	p300/SIRT1	ATG5乙酰化抑制自噬溶酶体的成熟	[46,47]
ATG7	—	p300/SIRT1	ATG7乙酰化抑制自噬	[46~48]
ATG3	K19、K48	Esa1/Rpd3	ATG3的乙酰化通过控制ATG3和ATG8的相互作用以及ATG8的脂化来调节自噬	[49,50]
Pacer	K483、K573	TIP60/—	Pacer的乙酰化是自噬体成熟和细胞脂质代谢所必需的	[51]
STX17	K219、K223	CBP/HDAC2	STX17被募集到自噬体膜后,STX17的去乙酰化是其在自噬溶酶体融合中发挥作用的必不可少的步骤	[52]

蛋白质乙酰化修饰对自噬的调控作用

The regulatory effect of protein acetylation modification on autophagy

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