miRNA介导PGR信号通路在雌性生殖功能调节中的作用机制

doi:10.16288/j.yczz.15-293

遗传 ›› 2016, Vol. 38 ›› Issue (1): 40-51.doi: 10.16288/j.yczz.15-293

miRNA介导PGR信号通路在雌性生殖功能调节中的作用机制

陈龙¹, 张宝云¹, 冯光德², 向伟¹, 马云霞¹, 陈航¹, 储明星³, 王凭青¹

1. 重庆大学生物工程学院,重庆 400030;
2. 四川铁骑力士牧业科技有限公司,绵阳 621000;
3. 中国农业科学院北京畜牧兽医研究所,农业部畜禽遗传资源与种质创新重点实验室,北京 100193

收稿日期:2015-06-24 修回日期:2015-09-05 出版日期:2016-01-20 发布日期:2016-01-20
通讯作者: 王凭青,博士,硕士生导师,研究方向：分子生物学与基因工程。Tel: 023-65112753;E-mail: wang_pq@21cn.com E-mail:chenlong19910522@163.com
作者简介:陈龙,硕士,专业方向：分子遗传学。
基金资助:
国家自然科学基金面上项目(编号：31372287),国家发改委重大专项(编号：2014-2573),国家科技重大专项(编号：2014ZX0800952B)和中国农业科学院科技创新工程(编号：ASTIP-IAS13)资助

The mechanism of miRNA-mediated PGR signaling pathway in regulating female reproduction

Long Chen¹, Baoyun Zhang¹, Guangde Feng², Wei Xiang¹, Yunxia Ma¹, Hang Chen¹, Mingxing Chu³, Pingqing Wang¹

1. Bioengineering Institute of Chongqing University, Chongqing 400030, China;
2. Sichuan TQLS Animal Husbandry Science and Technology Co., LTD, Mianyang 621000, China;
3. Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2015-06-24 Revised:2015-09-05 Online:2016-01-20 Published:2016-01-20
Supported by:
[Supported by the National Natural Science Foundation of China (No; 31372287), the Major Projects of Development and Reform Commission (No; 2014-2573), the National Science and Technology Major Projects of China (No; 2014ZX0800952B), Chinese Academy of Agricultural Science and Technology Innovation Project (No; ASTIP-IAS13)]

摘要/Abstract

摘要： MicroRNA(miRNA)作为重要的后转录调节因子参与多种生理活动。孕酮(Progesterone,P4)是重要的甾类激素,通过结合特异性受体——孕酮受体(Progesterone receptors , PGR)发挥生理作用。PGR作为核受体超家族的一员参与调控生殖相关组织或非生殖相关组织的功能。P4/PGR和miRNA可单独在雌性生殖中发挥调控作用。然而,在雌性生殖过程中,miRNA和P4/PGR的相互作用对调控排卵等雌性生殖活动起到非常重要的作用,但作用机制还未阐明。本文综述了miRNA调节P4产生、PGR基因表达以及P4/PGR调节miRNA表达的可能作用方式,为更好地研究miRNA和P4/PGR在雌性生殖中的作用提供理论基础。

关键词: miRNA, P4, 孕酮受体, 雌性生殖

Abstract: MicroRNAs (miRNAs) are involved in several physiological processes as important post-transcriptional regulators. Progesterone (P4), an important steroid hormone, produces physiological effect through binding specific receptor progesterone receptors (PGR) which regulates functions of both reproductive and non-reproductive tissues as a member of the nuclear receptor superfamily. P4/PGR and miRNAs could regulate female reproduction independently, however, it is still unclear how miRNAs and P4/PGR interaction regulates female reproductive activities such as ovulation in female reproduction. In this review, we summarize the possible ways in which miRNAs regulate P4 production and PGR gene expression as well as P4/PGR regulate miRNAs expression, which provide a theoretical basis for further studying the role of miRNAs and P4/PGR in female reproduction.

Key words: miRNA, progesterone, progesterone receptor, female reproduction

陈龙, 张宝云, 冯光德, 向伟, 马云霞, 陈航, 储明星, 王凭青. miRNA介导PGR信号通路在雌性生殖功能调节中的作用机制[J]. 遗传, 2016, 38(1): 40-51.

Long Chen, Baoyun Zhang, Guangde Feng, Wei Xiang, Yunxia Ma, Hang Chen, Mingxing Chu, Pingqing Wang. The mechanism of miRNA-mediated PGR signaling pathway in regulating female reproduction[J]. HEREDITAS(Beijing), 2016, 38(1): 40-51.

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miRNA介导PGR信号通路在雌性生殖功能调节中的作用机制

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