MicroRNA对肌肉再生功能调控研究进展

doi:10.16288/j.yczz.24-252

遗传 ›› 2025, Vol. 47 ›› Issue (5): 513-532.doi: 10.16288/j.yczz.24-252

MicroRNA对肌肉再生功能调控研究进展

周泰增¹^,²^,³(), 陈秋阳¹^,²^,³, 杨祎挺¹^,²^,³, 甘麦邻¹^,²^,³, 朱砺¹^,²^,³, 沈林園¹^,²^,³()

1.四川农业大学，猪禽种业全国重点实验室，成都 611130
2.四川农业大学，畜禽遗传资源发掘与创新利用四川省重点实验室，成都 611130
3.四川农业大学动物科技学院，农业农村部畜禽生物组学重点实验室，成都 611130

收稿日期:2024-09-02 修回日期:2024-12-08 出版日期:2025-05-20 发布日期:2025-01-10
通讯作者: 沈林園，博士，副教授，研究方向：猪的育种与分子遗传。E-mail: shenlinyuan@sicau.edu.cn
作者简介:周泰增，本科生，专业方向：动物遗传育种与繁殖。E-mail: zhoutaizeng666666@163.com
基金资助:
国家重点研发计划(2021YFD1200801);四川省科技计划(2021YFYZ0030);四川省科技计划(2021ZDZX0008);国家现代农业产业技术体系四川生猪创新团队项目(SCCXTD-2024-8);国家生猪产业体系项目(CARS-35);中央引导地方科技发展资金项目(2023ZYDF056)

Progress on the regulation of muscle regeneration by microRNA

Taizeng Zhou¹^,²^,³(), Qiuyang Chen¹^,²^,³, Yiting Yang¹^,²^,³, Mailin Gan¹^,²^,³, Li Zhu¹^,²^,³, Linyuan Shen¹^,²^,³()

1. National Key Laboratory of Pig and Poultry Seed Industry, Sichuan Agricultural University, Chengdu 611130, China
2. Sichuan Provincial Key Laboratory of Exploration and Innovative Utilization of Livestock and Poultry Genetic Resources, Sichuan Agricultural University, Chengdu 611130, China
3. Key Laboratory of Livestock and Poultry Biomics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China

Received:2024-09-02 Revised:2024-12-08 Published:2025-05-20 Online:2025-01-10
Supported by:
National Key Research and Development Program(2021YFD1200801);Sichuan Science and Technology Program(2021YFYZ0030);Sichuan Science and Technology Program(2021ZDZX0008);Program for Pig Industry Technology System Innovation Team of Sichuan Province(SCCXTD-2024-8);China Agriculture Research System(CARS-35);Central Government Guides the Local Science and Technology Development Fund Program(2023ZYDF056)

摘要/Abstract

摘要：

MicroRNA (miRNA)是一类大小在22 nt左右的单链非编码短RNA分子，已被证明参与了几乎所有细胞事件中基因表达的转录后调节，包括细胞增殖、迁移、分化和凋亡。因此，miRNA受到最为广泛的研究和关注。miRNA通过靶向骨骼肌再生不同阶段的关键因素，在肌肉再生过程中发挥着重要作用。本文探讨了miRNA在肌肉再生过程中通过影响卫星细胞静止、成肌细胞增殖、分化从而调控肌肉再生能力，并且更新了miRNA在肌肉再生过程中与PI3K/AKT、TGF-β/Smad信号通路互作的研究进展，有助于研究者更多地了解miRNA在肌肉再生生物学中的知识，为非编码RNA参与肌肉再生提供更深入的理解。

关键词: microRNA, 肌肉再生, 肌肉卫星细胞, 成肌细胞, 信号通路

Abstract:

MicroRNA (miRNA) is a class of single-stranded non-coding short RNA molecules about the size of 22 nt. Currently, miRNA has received the most extensive research and attention, and miRNA has been shown to be involved in the post-transcriptional regulation of gene expression in almost all cellular events, including cell proliferation, migration, differentiation, and apoptosis. miRNA plays an important role in the process of muscle regeneration by targeting key factors at different stages of skeletal muscle regeneration. In this review, we summarize the role of miRNA in regulating muscle regeneration by affecting satellite cell quiescence, myoblast proliferation, and differentiation during muscle regeneration, and update the relationship between miRNA and PI3K/AKT, TGF-β/Smad signaling during muscle regeneration. The research progress of pathway interaction will help researchers to learn more about the knowledge of miRNA in muscle regeneration biology, and provide a better understanding of the involvement of non-coding RNAs in muscle regeneration.

Key words: microRNA, muscle regeneration, muscle satellite cells, myoblasts, signaling pathways

周泰增, 陈秋阳, 杨祎挺, 甘麦邻, 朱砺, 沈林園. MicroRNA对肌肉再生功能调控研究进展[J]. 遗传, 2025, 47(5): 513-532.

Taizeng Zhou, Qiuyang Chen, Yiting Yang, Mailin Gan, Li Zhu, Linyuan Shen. Progress on the regulation of muscle regeneration by microRNA[J]. Hereditas(Beijing), 2025, 47(5): 513-532.

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miRNA	miRNA表达趋势	靶基因或调控对象	功能	参考文献
miR-708	上调	TNS3	拮抗细胞迁移来调节卫星静止和自我更新	[79]
miR-31	下调	IL-34	促进了增殖细胞的不对称细胞命运分离，导致卫星细胞重新进入静止状态	[80]
miR-489	上调	DEK	作为卫星细胞静止的调节剂	[81]
miR-31	上调	Myf5	抑制Myf5在静止卫星细胞中积累	[82]
miR-140	上调	Hey1、Notch1	抑制肌生成并维持肌肉卫星细胞静止	[83]
miR-378	上调	IGF1R	延迟卫星细胞活化	[84]

miRNA	miRNA表达趋势	靶基因或调控对象	功能	参考文献
miR-1、miR-29、miR-206、miR-27b、miR-128a	上调	Pax3	降低骨骼肌卫星细胞的增殖能力	[100~102]
miR-1、miR-106b、miR-133、miR-204、miR-206、miR-499	下调	Pax7	促进成肌细胞增殖	[103~107]
miR-208b	上调	CDKN1A	促进原代成肌细胞增殖	[108]
miR-33a	上调	CCND1	抑制成肌细胞增殖	[109]
miR-27b-3p	上调	MSTN	促进成肌细胞增殖	[110]
miR-22	上调	TGFBR1	抑制C2C12成肌细胞增殖	[111]
miR-452	上调	ANGPT1	促进C2C12成肌细胞增殖	[112]
miR-127-3p	上调	SEPT7	促进成肌细胞增殖	[113]
miR-365	上调	IGF-I	抑制成肌细胞增殖	[114]
miR-664-5p	上调	SRF	促进成肌细胞增殖	[115]
miR-499	上调	TGFβ-R1	抑制小鼠成肌细胞增殖	[116]
miR-543	上调	KLF6	抑制小鼠成肌细胞增殖	[117]
miR-16-5p	上调	SESN1	通过p53信号通路，抑制成肌细胞增殖	[118]
miR-130b	上调	Sp1	抑制成肌细胞增殖	[119]
miR-146b-3p	上调	AKT1、MDFIC	抑制PI3K/AKT通路，抑制鸡成肌细胞增殖	[120]
miR-92b-3p	上调	SGK3	抑制C2C12细胞增殖、迁移	[121]
miR-152	下调	E2F3	抑制成肌细胞增殖	[122]
miR-325-3p、miR-429-3p、miR-141-3p、miR-320-3p	上调	CFL2	增强细胞增殖和细胞周期进程	[123~126]
miR-103-3p、miR-302a、miR-665-3p	上调	TWF1	增强细胞增殖和细胞周期进程	[127~129]
miR-495-3p	下调	CDH2	抑制C2C12增殖	[130]
miR-100-5p	上调	TRIB2	促进成肌细胞增殖	[131]
miR-193b-3p	上调	IGF2BP1	促进山羊骨骼肌卫星细胞增殖	[132]
miR-222-3p、miR-487b-3p	下调	IRS1	抑制PI3K/AKT通路来抑制成肌细胞的增殖	[133,134]
miR-24-3p	上调	CAMK2B	促进牛肌肉原代细胞和C2C12细胞增殖	[135]

miRNA	miRNA表达趋势	靶基因或调控对象	功能	文献
miR-1、miR-206、miR-106b	上调	Pax7	促进肌源性分化	[103,107]
miR-16-5p	下调	SESN1	促进成肌细胞分化	[118]
miR-152	上调	E2F3	促进成肌细胞分化	[122]
miR-495-3p	上调	CDH2	促进C2C12成肌分化	[130]
miR-100-5p	下调	TRIB2	失活mTOR/S6K通路来抑制成肌细胞分化	[131]
miR-487b-3p	上调	IRS1	通过PI3K/AKT通路抑制C2C12的分化	[133]
miR-10b-5p	上调	NFAT5	抑制C2C12细胞分化	[137]
miR-424-5p	下调	HSP90AA1、Ezh1	抑制骨骼肌发育中的细胞分化	[75,143]
miR-9-5p	上调	IGF2BP3	抑制肌肉卫星细胞的分化	[145]
miR-148a-3p	上调	Meox2	激活PI3K/AKT通路来促进鸡成肌细胞的分化	[147]
miR-483	下调	IGF1	下调PI3/AKT信号通路关键蛋白的表达，抑制成肌细胞分化	[149]
miR-128	下调	SYNDECAN-4	抑制卫星细胞分化	[155]
miR-24	下调	GLYPICAN-1	抑制卫星细胞分化	[155]
miR-885	下调	MyoD1	抑制成肌细胞分化	[156]
miR-92a、miR-130b	下调	Sp1	诱导MyoD的表达，抑制成肌细胞分化	[119,157]
miR-22-3p、miR-29c、 miR-378a-3p、miR-206	上调	HDAC4	调节骨骼肌生长并促进成肌细胞的分化	[155,158~160]
miR-214	上调	TRMT61A	促进鸡成肌细胞分化	[161]
miR-24-3p	上调	Hmga1	促进骨骼肌分化	[162]
miR-29c	下调	IGF1	促进山羊原代成肌细胞的分化	[163]
miR-103-3p	下调	TWF1、BTG2、MAP4	抑制C2C12成肌分化	[127,164,165]

MicroRNA对肌肉再生功能调控研究进展

Progress on the regulation of muscle regeneration by microRNA

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