人microRNA相关的遗传变异与肿瘤

doi:10.3724/SP.J.1005.2011.00870

遗传 ›› 2011, Vol. 33 ›› Issue (8): 870-878.doi: 10.3724/SP.J.1005.2011.00870

人microRNA相关的遗传变异与肿瘤

李佩尧^1,2, 贺福初^1,2, 周钢桥^1,2

1. 军事医学科学院放射与辐射医学研究所, 蛋白质组学国家重点实验室, 基因组学与蛋白质组学研究室, 北京 100850 2. 北京蛋白质组研究中心, 功能基因组学研究室, 北京 102206

收稿日期:2011-04-01 修回日期:2011-05-25 出版日期:2011-08-20 发布日期:2011-08-25
通讯作者: 李佩尧 E-mail:lipeiyao214@yahoo.com.cn
基金资助:
国家科技重大专项(编号：2008ZX10002-016)和国家自然科学基金项目(编号：30900819, 30901707)资助

Association of human microRNA related genetic variations with cancer

LI Pei-Yao^{1, 2}, HE Fu-Chu^{1, 2}, ZHOU Gang-Qiao^{1, 2}

1. Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China 2. Department of Functional Genomics, Beijing Proteome Research Center, Beijing 102206, China

Received:2011-04-01 Revised:2011-05-25 Online:2011-08-20 Published:2011-08-25

摘要/Abstract

摘要： 微RNA(microRNA, miRNA)是新发现的一类进化上高度保守的重要的转录后调控因子, 通过调节基因的表达而参与调控细胞凋亡、增殖及分化等生理过程, 同时与肿瘤等疾病的发生发展密切相关。近年来研究发现, miRNA、miRNA生物合成通路基因及miRNA的靶基因结合位点的遗传变异(例如单核苷酸多态性和拷贝数变异等)可影响miRNA调控功能的发挥, 并产生显著的遗传学效应。文章主要综述了miRNA相关的遗传变异与肿瘤易感性和临床转归等的研究进展。

关键词: microRNA, 单核苷酸多态性, 拷贝数变异, 肿瘤

Abstract: microRNAs (miRNAs) are a highly conserved class of small noncoding RNAs that regulate gene expression by post-transcriptional degradation or translational repression. miRNAs are involved in the regulation of cell apoptosis, prolif-eration, differentiation and other physiological processes, and are closely related with the development of cancer. More recently, it has been proposed that the presence of genetic variations (e.g., single nucleotide polymorphism and copy num-ber variation) in microRNA genes, their biogenesis pathway and target binding sites affect the miRNA processing machin-ery and targeting, and have a significant genetic effect. In this review, we focus on the miRNA-related genetic variations and cancer susceptibility and progression.

Key words: microRNA, polymorphism, copy number variation, cancer

中图分类号:

Q347

李佩尧，贺福初，周钢桥. 人microRNA相关的遗传变异与肿瘤[J]. 遗传, 2011, 33(8): 870-878.

LI Pei-Yao, HE Fu-Chu, ZHOU Gang-Qiao. Association of human microRNA related genetic variations with cancer[J]. HEREDITAS, 2011, 33(8): 870-878.

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人microRNA相关的遗传变异与肿瘤

Association of human microRNA related genetic variations with cancer

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