细菌几丁质酶基因的表达调控

doi:10.3724/SP.J.1005.2011.01029

遗传 ›› 2011, Vol. 33 ›› Issue (10): 1029-1038.doi: 10.3724/SP.J.1005.2011.01029

细菌几丁质酶基因的表达调控

谢池楚¹, 贾海云¹, 陈月华^{1, 2}

1. 南开大学微生物学系, 天津 300071 2. 分子微生物学与技术教育部重点实验室, 天津 300071

收稿日期:2011-03-31 修回日期:2011-06-14 出版日期:2011-10-20 发布日期:2011-10-25
通讯作者: 陈月华 E-mail:yhchen@nankai.edu.cn
基金资助:
国家自然科学基金项目(编号：30971957)资助

Regulation of chitinase genes expression in bacteria

XIE Chi-Chu¹, JIA Hai-Yun¹, CHEN Yue-Hua^{1, 2}

1. Department of Microbiology, Nankai University, Tianjin 300071, China 2. Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin 300071, China

Received:2011-03-31 Revised:2011-06-14 Online:2011-10-20 Published:2011-10-25

摘要/Abstract

摘要： 几丁质酶可以降解几丁质, 广泛存在于各类微生物中。几丁质的降解产物几丁寡糖在医药、食品及农业生防领域有很重要的应用价值及广泛的应用前景。细菌在利用几丁质时, 需要先分泌几丁质酶, 将几丁质降解成几丁寡糖或单体, 再通过特异的转运系统送进细胞而被利用。胞内的几丁质降解产物作为特定的信号分子, 可以激活或阻遏相应chi基因的转录, 从而影响细菌几丁质酶的合成。在各种调节蛋白及应答元件的参与下, 细菌几丁质酶的合成受到精密的控制。文章以链霉菌和大肠杆菌为代表综述了细菌在转运系统和基因表达两个层面上控制几丁质酶合成的最新研究进展。

关键词: 细菌, 几丁质酶基因, 转运系统, 表达调控

Abstract: Chitinases, which can hydrolyze chitin, occur in a wide range of microorganisms including viruses, bacteria, and fungi. The derivatives of chitin are potentially useful in several areas such as food processing, medicines, and biological control in agriculture. Some bacteria can uptake and utilize chitin as carbon source by secreting chitinase. The chitin is degraded into chito-oligosaccharides [(GlcNAc)_n] or N-acetylglucosamine (GlcNAc) by chitinases, and then the chitin derivatives are transferred into cells by specific transport systems of bacteria. The intracellular chitin derivatives activate or suppress the transcription of a series of chi genes and affect the amount of chitinase. The expression of chitinase genes are strictly regulated by various regulatory factors and responsive cis-acting elements. The present review will focus on the transport system and the regulation of chitinase genes expression in bacteria.

Key words: bacteria, chitinase gene, transport system, regulation

谢池楚，贾海云，陈月华. 细菌几丁质酶基因的表达调控[J]. 遗传, 2011, 33(10): 1029-1038.

XIE Che-Chu, GU Hai-Yun, CHEN Ru-Hua. Regulation of chitinase genes expression in bacteria[J]. HEREDITAS, 2011, 33(10): 1029-1038.

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细菌几丁质酶基因的表达调控

Regulation of chitinase genes expression in bacteria

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