甲状旁腺激素样激素在胚胎发育中的作用

doi:10.3724/SP.J.1005.2014.0871

遗传 ›› 2014, Vol. 36 ›› Issue (9): 871-878.doi: 10.3724/SP.J.1005.2014.0871

甲状旁腺激素样激素在胚胎发育中的作用

李园园^{1, 2}, 郭磊², 卢晟盛¹, 韩之明²

1. 广西大学动物科学技术学院,南宁 530004; 2. 中国科学院动物研究所,计划生育生殖生物学国家重点实验室,北京 100101

收稿日期:2014-04-29 出版日期:2014-09-20 发布日期:2014-09-20
通讯作者: 韩之明,博士,副研究员,专业方向：发育生物学。E-mail: hanzm@ioz.ac.cn E-mail:liyuanyuan16@sina.cn
作者简介:李园园,硕士研究生,专业方向：发育生物学。
基金资助:
国家自然科学基金项目(编号：31372144)资助

Role of parathyroid hormone-like hormone during embryonic development

Yuanyuan Li^{1, 2}, Lei Guo², Shengsheng Lu¹, Zhiming Han²

1. College of Animal Science and Technology, Guangxi University, Nanning 530004, China; 2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

Received:2014-04-29 Online:2014-09-20 Published:2014-09-20

摘要/Abstract

摘要： 甲状旁腺激素样激素(Parathyroid hormone-like hormone, PTHLH)又称为甲状旁腺激素相关蛋白(Parathyroid hormone-related protein, PTHrP),发现初期被认为是引起人类恶性肿瘤伴发的高钙血症的主要原因。进一步的研究发现,PTHLH在不同物种的多种成体和胎儿组织中均有表达,其生物学作用涉及形态发生、细胞生长与分化的调控、胎盘钙的转运等多个方面。文章主要综述了PTHLH的生物学特性及其在胚胎发育过程中的作用,并进一步探讨了涉及的信号通路及可能的作用机制。

关键词: 甲状旁腺激素样激素, 胚胎发育, 信号通路

Abstract: Parathyroid hormone-like hormone (PTHLH), also known as parathyroid hormone-related protein (PTHrP), was first identified as a parathyroid hormone (PTH)-like factor responsible for humoral hypercalcaemia in malignancies. Subsequent studies demonstrated that PTHLH has multiple physiological functions in many fetal and adult tissues, including the regulation of morphogenesis, cell proliferation and differentiation, and transplacental calcium transport. This review focuses on the biological characteristics of PTHLH and its function during embryonic development. The signaling pathway and potential mechanism involved are further discussed.

Key words: parathyroid hormone-like hormone, embryonic development, signaling pathway

李园园, 郭磊, 卢晟盛, 韩之明. 甲状旁腺激素样激素在胚胎发育中的作用[J]. 遗传, 2014, 36(9): 871-878.

Yuanyuan Li, Lei Guo, Shengsheng Lu, Zhiming Han. Role of parathyroid hormone-like hormone during embryonic development[J]. HEREDITAS(Beijing), 2014, 36(9): 871-878.

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甲状旁腺激素样激素在胚胎发育中的作用

Role of parathyroid hormone-like hormone during embryonic development

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