遗传 ›› 2006, Vol. 28 ›› Issue (2): 243-248.

• 专论与综述 • 上一篇    下一篇

PPAR基因与脂肪代谢调控

柳晓峰;李 辉   

  1. 东北农业大学动物科技学院,哈尔滨 150030
  • 收稿日期:2005-06-02 修回日期:2005-07-19 出版日期:2006-02-10 发布日期:2006-02-10
  • 通讯作者: 李辉

Regulation of Fat Metabolism by PPARs

LIU Xiao-Feng, LI Hui   

  1. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China
  • Received:2005-06-02 Revised:2005-07-19 Online:2006-02-10 Published:2006-02-10
  • Contact: LI Hui

摘要: 过氧化物酶体增值剂激活受体(PPARs)基因属于类固醇/甲状腺/维甲酸受体超家族,有3个亚型,即:PPAR-α、PPAR-β和PPAR-γ。PPARs具有多种生物学功能,如增强机体对胰岛素敏感性,调节体内糖平衡等,尤其在脂肪分化、生成等多方面起到重要作用,是目前的研究热点,文章从PPARs基因的结构,表达及功能等方面讨论了其与脂肪代谢调控的关系。

关键词: PPAR基因, 脂肪, 表达, 功能

Abstract:  Peroxisome proliferator activated receptors (PPARs) belong to the nuclear receptor superfamily. PPARs have diverse biological functions such as enhancing insulin sensitivity, regulating saccharometabolism homeostasis, and especially regulation of lipid homeostasis, which is the focus of much of the researches at present. In this article, we summarize the regulation of fat metabolism by PPAR genes based on their structure, function and expression.

中图分类号: