MicroRNA对皮肤毛囊发育的调控机制

doi:10.3724/SP.J.1005.2014.0655

遗传 ›› 2014, Vol. 36 ›› Issue (7): 655-660.doi: 10.3724/SP.J.1005.2014.0655

MicroRNA对皮肤毛囊发育的调控机制

张璐, 张燕军, 苏蕊, 王瑞军, 李金泉

内蒙古农业大学动物科学学院, 动物遗传育种与繁殖自治区重点实验室, 呼和浩特 010018

收稿日期:2013-12-03 出版日期:2014-07-20 发布日期:2014-06-23
通讯作者: 张燕军, 博士, 副教授, 研究方向：绒山羊遗传育种。E-mail: imauzyj@163.com
作者简介:张璐, 在读硕士研究生, 专业方向：绒山羊育种。E-mail:zl63412732@163.com
基金资助:
国家自然科学基金项目(编号：31260539), 国家农业部现代农业产业技术体系项目(编号：CARS-40-05)和国家高技术研究发展计划项目(863计划)(编号：2013AA102506)资助

The regulatory mechanism of microRNAs in skin and hair follicle development

Lu Zhang, Yanjun Zhang, Rui Su, Ruijun Wang, Jinquan Li

Inner Mongolia Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received:2013-12-03 Online:2014-07-20 Published:2014-06-23

摘要/Abstract

摘要： MicroRNA是参与转录后水平表达调控的重要因子, 在病理上成为药物作用的潜在靶点, 在生理上成为表型调控的潜在位点。目前, 对于microRNA的功能已有一定了解, 但其在皮肤毛囊发育中的作用机制还不完全清楚。近年来, 高通量测序技术为microRNA的鉴定提供了更准确、快速的途径, 研究发现一些microRNA能够影响皮肤毛囊细胞的分化和增殖, 其相关靶基因在调控毛囊周期性生长的过程中充当重要角色。文章综述了近年来microRNA在皮肤毛囊生长发育调控机制研究领域所取得的成果, 以期为后续开展绒山羊毛囊生长相关microRNA作用机制研究提供借鉴。

关键词: microRNA, 皮肤, 毛囊, 调控机制

Abstract: MicroRNAs (miRNAs) are an emerging class of regulators that control post-transcriptional processes, and could be potential targets for drug in pathology and potential sites of phenotypic regulation. Although some functions of miRNAs have been known, the regulatory mechanism of miRNAs in skin and hair follicle development remains unclear. High throughput sequencing provides more accurate and rapid method for identification of miRNAs. It has been found that some miRNAs affect the cell differentiation and proliferation of skin and hair follicles, and their target genes play important roles in the periodic growth of hair follicles. In this review, we summarize the recent achievements of the regulatory mechanism of miRNAs in the skin follicles and provide useful clues for further study on miRNA regulation in hair follicle growth of cashmere goat.

Key words: microRNA, skin, hair follicle, regulatory mechanism

张璐, 张燕军, 苏蕊, 王瑞军, 李金泉. MicroRNA对皮肤毛囊发育的调控机制[J]. 遗传, 2014, 36(7): 655-660.

Lu Zhang, Yanjun Zhang, Rui Su, Ruijun Wang, Jinquan Li. The regulatory mechanism of microRNAs in skin and hair follicle development[J]. HEREDITAS(Beijing), 2014, 36(7): 655-660.

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MicroRNA对皮肤毛囊发育的调控机制

The regulatory mechanism of microRNAs in skin and hair follicle development

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