肾脏发育中信号通路的调控作用

doi:10.16288/j.yczz.2015.01.001

遗传 ›› 2015, Vol. 37 ›› Issue (1): 1-7.doi: 10.16288/j.yczz.2015.01.001

• 综述 • 下一篇

肾脏发育中信号通路的调控作用

邱晓^{1, 2}, 韦荣飞^{1, 2}, 张令强², 贺福初^{1, 2}

1. 清华大学生命科学学院,北京 100089;
2. 军事医学科学院放射与辐射医学研究所,蛋白质组学国家重点实验室,北京 100850

收稿日期:2014-07-26 修回日期:2014-10-15 出版日期:2015-01-20 发布日期:2015-01-20
通讯作者: 张令强,研究员,研究方向：蛋白质泛素化修饰与疾病。E-mail: zhanglq550@163.com E-mail:zhanglq550@163.com
作者简介:邱晓,在读博士研究生,研究方向：细胞生物学。E-mail: sdsqiuxiao378@126.com韦荣飞,在读博士研究生,研究方向：细胞生物学。E-mail: weirongfei2010@163.com
基金资助:
国家自然科学基金项目(编号：31125010,31471364)和重大科学研究计划课题部分项目(编号：2012CB910304,2011CB910602)资助

The roles of signaling pathways in regulating kidney development

Xiao Qiu^{1, 2}, Rongfei Wei^{1, 2}, Lingqiang Zhang², Fuchu He^{1, 2}

1. School of Life Sciences, Tsinghua University, Beijing 100089, China; 2. State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China

Received:2014-07-26 Revised:2014-10-15 Online:2015-01-20 Published:2015-01-20

摘要/Abstract

摘要： 肾脏发育是一个复杂的过程,需要在输尿管芽细胞和基质细胞相互诱导下,引起细胞生长、增殖、分化,从而产生肾单位及各种管状结构,最终发育为成熟的肾脏。在肾脏发育过程中,GDNF/Ret、Wnt、BMP等一系列信号通路参与了发育的调控过程。这些信号通路在肾脏发育的不同阶段或不同位置发挥着重要的调控作用,并且通路之间存在相互的调控,从而形成了一个复杂而精细的调控网络,保证了肾脏的正常发育。文章概括了肾脏发育的过程,总结了肾脏发育过程中相关信号通路对肾脏发育的调控作用以及信号通路之间的相互调控。

关键词: 肾脏发育, GDNF/Ret, Wnt, BMP, FGF, Notch

Abstract: The development of mammalian kidney is a complex process. The reciprocal inductive interactions between epithelial cells and metanephric mesenchymal cells determine cell fates including proliferation, growth, apoptosis, and eventually contribute to the formation of an intact kidney. Multiple signaling pathways, including the GDNF/Ret, Wnt and BMP signaling pathways, have been shown to regulate the development of kidney. A myriad of signaling pathways and their cross-talks form a precise spatiotemporal regulatory network, which ensures the kidney to be properly organized. In this review, we summarize the physiological process of kidney development as well as the involved signaling pathways and their interplay.

Key words: kidney development, GDNF/Ret, Wnt, BMP, FGF, Notch

邱晓, 韦荣飞, 张令强, 贺福初. 肾脏发育中信号通路的调控作用[J]. 遗传, 2015, 37(1): 1-7.

Xiao Qiu, Rongfei Wei, Lingqiang Zhang, Fuchu He. The roles of signaling pathways in regulating kidney development[J]. HEREDITAS(Beijing), 2015, 37(1): 1-7.

参考文献

[1] Chai OH, Song CH, Park SK, Kim W, Cho ES. Molecular regulation of kidney development. Anat Cell Biol , 2013, 46(1): 19-31.
[2] Patel SR, Dressler GR. The genetics and epigenetics of kidney development. Semin Nephrol , 2013, 33(4): 314-326.
[3] Faa G, Gerosa C, Fanni D, Monga G, Zaffanello M, Van Eyken P, Fanos V. Morphogenesis and molecular mechanisms involved in human kidney development. J Cell Physiol , 2012, 227(3): 1257-1268.
[4] Dressler GR. The cellular basis of kidney development. Annu Rev Cell Dev Biol , 2006, 22: 509-529.
[5] Sequeira Lopez MLS, Gomez RA. Development of the renal arterioles. J Am Soc Nephrol , 2011, 22(12): 2156-2165.
[6] Davis TK, Hoshi M, Jain S. To bud or not to bud: the RET perspective in CAKUT. Pediatr Nephrol , 2014, 29(4): 597- 608.
[7] Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature , 1994, 367(6461): 380-383.
[8] Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, Sariola H, Westphal H. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature , 1996, 382(6586): 73-76.
[9] Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F. Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Dev Cell , 2009, 17(2): 199-209.
[10] Hoshi M, Batourina E, Mendelsohn C, Jain S. Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice. Development , 2012, 139(13): 2405-2415.
[11] Costantini F. GDNF/Ret signaling and renal branching morphogenesis: From mesenchymal signals to epithelial cell behaviors. Organogenesis , 2010, 6(4): 252-262.
[12] Tang MJ, Cai Y, Tsai SJ, Wang YK, Dressler GR. Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase. Dev Biol, 2002, 243(1): 128-136.
[13] Yang YZ. Wnt signaling in development and disease. Cell Biosci , 2012, 2(1): 14.
[14] Freese JL, Pino D, Pleasure SJ. Wnt signaling in development and disease. Neurobiol Dis , 2010, 38(2): 148-153.
[15] Stark K, Vainio S, Vassileva G, McMahon AP. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature , 1994, 372(6507): 679-683.
[16] Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell , 2005, 9(2): 283-292.
[17] Park JS, Valerius MT, McMahon AP. Wnt/β-catenin signaling regulates nephron induction during mouse kidney development. Development , 2007, 134(13): 2533-2539.
[18] Fischer E, Legue E, Doyen A, Nato F, Nicolas JF, Torres V, Yaniv M, Pontoglio M. Defective planar cell polarity in polycystic kidney disease. Nat Genet , 2006, 38(1): 21-23.
[19] Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet , 2009, 41(7): 793-799.
[20] Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP. A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development , 2009, 136(1): 161-171.
[21] Oxburgh L, Brown AC, Muthukrishnan SD, Fetting JL. Bone morphogenetic protein signaling in nephron progenitor cells. Pediat Nephrol , 2014, 29(4): 531-536.
[22] Pope JC 4th, Brock JW 3rd, Adams MC, Stephens FD, Ichikawa I. How they begin and how they end: classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract, CAKUT. J Am Soc Nephrol , 1999, 10(9): 2018-2028.
[23] Dudley

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

肾脏发育中信号通路的调控作用

The roles of signaling pathways in regulating kidney development

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	龚一鸣, 王翔宇, 贺小云, 刘玉芳, 余平, 储明星, 狄冉. 绵羊FecB突变对BMPR1B活性及BMP/SMAD通路的影响研究进展[J]. 遗传, 2023, 45(4): 295-305.
[2]	郑鹏飞, 谢海波, 朱盼盼, 赵呈天. 斑马鱼神经底板处神经元的分布及特征[J]. 遗传, 2022, 44(6): 510-520.
[3]	万星琦, 魏婉珍, 郭胜良, 崔一笑, 景雪莹, 黄露杰, 马捷. BMP2基因远程调控元件的功能分析[J]. 遗传, 2022, 44(12): 1141-1147.
[4]	王姗姗, 赵琬怡, 吴慧潇, 舒梦, 袁嘉欣, 方丽, 徐潮. 特发性低促性腺激素性性腺功能减退症FGFR1与CEP290基因变异研究[J]. 遗传, 2022, 44(10): 937-949.
[5]	贾婷婷, 雷蕾, 吴歆媛, 蔡顺有, 陈艺璇, 薛钰. 二甲双胍对斑马鱼骨骼发育及损伤修复的机制研究[J]. 遗传, 2022, 44(1): 68-79.
[6]	张春霞, 刘峰. 造血干细胞发育过程中的信号通路调控[J]. 遗传, 2021, 43(4): 295-307.
[7]	赵晓琪, 敖英, 陈海云, 汪晖. miRNA与肾脏发育[J]. 遗传, 2020, 42(11): 1062-1072.
[8]	吕赵劼, 王志浩, 卢淑娴, 刘沛蓉, 田静. 短指(趾)症及指(趾)骨发育的分子调控机制[J]. 遗传, 2019, 41(12): 1073-1083.
[9]	杨志, 姚俊, 曹新. FGF信号通路在内耳发育调控和毛细胞再生中的作用[J]. 遗传, 2018, 40(7): 515-524.
[10]	刘旭, 张平, 张晓枫, 李兴, 白宇, 贾克荣, 郭晓东, 张豪, 马晓燕, 仓明, 刘东军, 郭旭东. 利用CRISPR/Cas9系统构建FGF21基因敲除小鼠模型[J]. 遗传, 2018, 40(1): 66-74.
[11]	范晴晴, 孟飞龙, 房冉, 李高鹏, 赵小立. Wnt信号通路在毛细胞分化和再生过程中的作用[J]. 遗传, 2017, 39(10): 897-907.
[12]	王敏,石翾,黄翔,刘小凤,覃玉凤,刘小红,陈瑶生,何祖勇. 应用RGS双荧光替代性报告载体提高CRISPR/Cas9对猪BMP15基因的打靶效率[J]. 遗传, 2017, 39(1): 48-55.
[13]	张蔓丽, 卢彦平, 李亚里. 初级纤毛与Wnt信号通路相关性研究进展[J]. 遗传, 2015, 37(3): 233-239.
[14]	许飞, 张进, 马端. Hippo/YAP和Wnt/β-catenin通路的对话[J]. 遗传, 2014, 36(2): 95-102.
[15]	侯晓明，陈星，王玉林. Pax2在肾脏发育和肾疾病中的调控作用[J]. 遗传, 2011, 33(9): 931-938.