遗传 ›› 2017, Vol. 39 ›› Issue (7): 597-606.doi: 10.16288/j.yczz.17-056

• 综述 • 上一篇    下一篇

Hippo信号通路在肺发育、再生和疾病中的功能

付思玲1,2(),赵婉滢1,3(),张雯婧4(),宋海5(),季红斌4(),汤楠1()   

  1. 1. 北京生命科学研究所,北京 102206
    2. 北京协和医学院,北京 100005
    3. 清华大学生命科学学院,北京 100084
    4. 中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海 200031
    5. 浙江大学生命科学学院,杭州 310058
  • 收稿日期:2017-02-21 修回日期:2017-03-22 出版日期:2017-07-20 发布日期:2017-05-31
  • 作者简介:付思玲,学士,专业方向：生物化学与分子生物学。E-mail: fusiling@nibs.ac.cn|赵婉滢,学士,专业方向：发育生物学。E-mail: zhaowanying@nibs.ac.cn|张雯婧,学士,专业方向：分子生物学。E-mail: zjhzwjzhang@126.com|宋海,博士,教授,研究方向：肺发育与再生。E-mail: haisong@zju.edu.cn|季红斌,博士,研究员,研究方向：肺癌发病分子机理。E-mail: hbji@sibcb.ac.cn|汤楠,博士,研究员,研究方向：肺发育与再生。E-mail: tangnan@nibs.ac.cn
  • 基金资助:
    国家重点基础研究发展规划(973计划)项目(2014CB850003);国家自然科学基金面上项目(31471368);国家杰出青年科学基金项目(81325015)

Hippo signaling pathway in lung development, regeneration, and diseases

Siling Fu1,2(),Wanying Zhao1,3(),Wenjing Zhang4(),Hai Song5(),Hongbin Ji4(),Nan Tang1()   

  1. 1. National Institute of Biological Sciences, Beijing 102206, China
    2. Graduate School of Peking Union Medical College, Beijing 100005, China
    3. School of Life Science,Tsinghua University, Beijing 100084, China
    4. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    5. School of Life Science, Zhejiang University, Hangzhou 310058, China
  • Received:2017-02-21 Revised:2017-03-22 Online:2017-07-20 Published:2017-05-31
  • Supported by:
    the National Basic Research Program of China(2014CB850003);the National Natural Science Foundation of China(31471368);the National Science Foundation for Distinguished Young Scholars(81325015)

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摘要：

哺乳动物肺对于血液与外部环境之间的气体交换至关重要。而肺相关的疾病是现代人死亡的主要原因之一。肺的发育、再生和相关疾病的研究对临床治疗具有重要的指导作用。研究发现,Hippo信号通路参与细胞增殖与分化的调控、器官大小的控制,以及机械力的感应和传递。Hippo信号通路中的核心转录调控分子YAP/TAZ在肺部的多种细胞中均有表达,其表达及定位的变化在肺发育与再生中发挥着重要的调控作用。本文主要介绍了Hippo信号通路在肺生长发育中的功能及其与肺纤维化、肺癌的关系,并从肺泡力学和肺泡相关免疫两个角度对Hippo信号通路潜在的功能进行了展望。

关键词: Hippo信号通路, 肺发育与再生, 肺癌, 肺纤维化

Abstract:

The mammalian lung is essential for the gas exchange function between the circulation and the atmospheric environment. Lung diseases, including lung cancer, are among the leading causes of death in the modern society. Research on lung development, regeneration and cancer could provide significant insights for the development of therapeutic approaches on lung diseases. Hippo/YAP/TAZ signaling pathway regulates cell proliferation and differentiation, controls organ size, and plays an important role in response to mechanical forces. YAP/TAZ are expressed in many cell types and serve various regulatory functions in the embryonic and adult lungs. In this review, we mainly focus on the roles of Hippo/YAP/TAZ signaling pathway in embryonic lung development, regeneration and cancer. We postulate that Hippo/YAP/TAZ signaling may play potential roles in regulating the alveolar mechanics and immune responses in the lung.

Key words: Hippo signaling pathway, lung development and regeneration, lung cancer, lung fibrosis