脉络丛及其与衰老相关疾病的关系

doi:10.16288/j.yczz.23-294

遗传 ›› 2024, Vol. 46 ›› Issue (2): 109-125.doi: 10.16288/j.yczz.23-294

脉络丛及其与衰老相关疾病的关系

杨韵霏¹(), 沈义栋^2,³()

1.重庆医科大学附属第一医院老年病科，重庆 400016
2.中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)，细胞生物学国家重点实验室，细胞信号网络协同创新中心，上海 200031
3.中国科学院大学，北京 100049

收稿日期:2023-11-30 修回日期:2024-01-02 出版日期:2024-02-20 发布日期:2024-01-25
通讯作者: 沈义栋 E-mail:yangyunfei@sibcb.ac.cn;yidong.shen@sibcb.ac.cn
作者简介:杨韵霏，博士研究生，专业方向：衰老及衰老相关疾病的机理研究。E-mail: yangyunfei@sibcb.ac.cn
基金资助:
国家自然科学基金项目(32270802)

Choroid plexus and its relations with age-related diseases

Yunfei Yang¹(), Yidong Shen^2,³()

1. Department of Geriatric, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
2. State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai 200031, China
3. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2023-11-30 Revised:2024-01-02 Published:2024-02-20 Online:2024-01-25
Contact: Yidong Shen E-mail:yangyunfei@sibcb.ac.cn;yidong.shen@sibcb.ac.cn
Supported by:
National Natural Science Foundation of China(32270802)

摘要/Abstract

摘要：

脉络丛由位于基底层上的上皮细胞组成，相邻脉络丛上皮细胞之间的紧密连接形成了血脑脊液屏障，它与血脑屏障一起对大脑微环境的稳态至关重要。脉络丛上皮可向脑室分泌脑脊液、生长因子、神经肽和脂类物质，同时脉络丛也是免疫细胞进入大脑的门户。衰老和神经退行性疾病的病理生理学仍然还存在大量未知，越来越多的研究将脉络丛与这些年龄相关性疾病的病因关联起来。本文综述了目前已知的脉络丛上皮与年龄相关疾病之间的关系，以期为防治相关疾病提供新的线索。

关键词: 脉络丛, 脑脊液, 衰老, 神经退行性疾病

Abstract:

The choroid plexus is composed of epithelial cells situated on the basal layer. The tight junctions between adjacent choroid plexus epithelial cells establish the blood-cerebrospinal fluid barrier. This barrier, in conjunction with the blood-brain barrier, is crucial for the homeostasis of the brain microenvironment. The choroid plexus epithelium secretes cerebrospinal fluid, growth factors, neuropeptides, and lipids into the ventricles and also serves as a gateway for immune cells to enter the brain. The pathophysiology of aging and neurodegenerative diseases remains largely enigmatic, with an increasing body of research linking the choroid plexus to the etiology of these age-related disorders. In this review, we summarize the known relationship between the choroid plexus epithelium and age-related diseases, aiming to provide new therapeutic clues for these disorders.

Key words: choroid plexus, cerebrospinal fluid, aging, neurodegenerative diseases

杨韵霏, 沈义栋. 脉络丛及其与衰老相关疾病的关系[J]. 遗传, 2024, 46(2): 109-125.

Yunfei Yang, Yidong Shen. Choroid plexus and its relations with age-related diseases[J]. Hereditas(Beijing), 2024, 46(2): 109-125.

图/表 2

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