遗传 ›› 2009, Vol. 31 ›› Issue (11): 1094-1100.doi: 10.3724/SP.J.1005.2009.01094

• 综述 • 上一篇    下一篇

miR-17-92基因簇microRNAs对哺乳动物器官发育及肿瘤发生的调控

张振武;安洋;滕春波

  

  1. 东北林业大学生命科学学院发育生物学研究室, 哈尔滨 150040

  • 收稿日期:2009-04-29 修回日期:2009-06-20 出版日期:2009-11-10 发布日期:2009-11-10
  • 通讯作者: 滕春波

The roles of miR-17-92 cluster in mammal development and tumori-genesis

ZHANG Zhen-Wu;AN Yang;TENG Chun-Bo   

  1. Laboratory of Animal Development Biology, College of Life Science, Northeast Forestry University, Harbin 150040, China

  • Received:2009-04-29 Revised:2009-06-20 Online:2009-11-10 Published:2009-11-10
  • Contact: TENG Chun-Bo1

摘要:

microRNAs(miRNAs)是近年发现的一种高度保守的非编码小RNA, 它们通过抑制靶基因mRNA的翻译或将其降解, 在转录后水平调控基因的表达, 参与调控哺乳动物多个器官的发育过程和人类疾病的发生。miR-17-92基因簇是一个高度保守的基因簇, 编码miR-17-5p、miR-17-3p、miR-18a、miR-19a、miR-20a、miR-19b-1和miR-92-1等7个miRNAs。大量证据表明, miR-17-92基因簇miRNAs参与了心、肺、免疫系统的发育、血管生长及前脂肪细胞的分化等过程。此外, miR-17-92基因簇miRNAs在多种肿瘤中高表达, 能作为致癌基因诱发淋巴瘤和血管化肿瘤的发生, 但它也可以作为抑癌基因抑制乳腺癌细胞的增殖。文章对miR-17-92基因簇miRNAs在哺乳动物器官发育及肿瘤发生中的作用进行综述

关键词: 肿瘤发生, miR-17-92基因簇, 发育

Abstract:

MicroRNAs (miRNAs) are a new class of small, non-coding RNAs that regulate gene expression. The base pairing interactions between miRNAs and their target mRNAs, often within the 3’-untranslated region (UTR) of target genes, result in the degradation of target mRNAs or repression of their translation. MiRNAs regulate a diverse range of physiological processes, including cell differentiation and proliferation, mammalian development and human disease. Many studies have shown that miR-17-92 cluster, which encodes miR-17-5p, miR-17-3p, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92-1, is expressed in many mammalian tissues. This cluster contributes to the development of heart, lung, blood vessel, and immune system. In addition, it can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene. However, miR-17-92 cluster proved to suppress breast cancer cell proliferation and tumor colony formation as a tumor suppressor. This paper reviews the roles of miR-17-92 cluster in mammal development and the relationship between miR-17-92 cluster and tumorigenesis.