遗传 ›› 2013, Vol. 35 ›› Issue (6): 695-702.doi: 10.3724/SP.J.1005.2013.00695

• 综述 • 上一篇    下一篇

乳腺发育及泌乳相关miRNA研究进展

金晓露, 杨建香, 李真, 刘红云, 刘建新   

  1. 浙江大学动物科学学院奶业科学研究所, 杭州 310058
  • 收稿日期:2012-10-20 修回日期:2012-12-30 出版日期:2013-06-20 发布日期:2013-06-25
  • 通讯作者: 刘建新 E-mail:liujx@zju.edu.cn
  • 基金资助:

    国家重点基础研究发展计划(973 计划)项目(编号:2011CB100801)资助

Progress on the miRNA related with mammary gland development and lactation

JIN Xiao-Lu, YANG Jian-Xiang, LI Zhen, LIU Hong-Yun, LIU Jian-Xin   

  1. Institute of Dairy Science, College of Animal Science, Zhejiang University, Hangzhou 310058, China
  • Received:2012-10-20 Revised:2012-12-30 Online:2013-06-20 Published:2013-06-25

摘要: MicroRNA(miRNA)是一种重要的转录后调控的非编码RNA, 参与调控哺乳动物乳腺发育和泌乳。文章总结了乳腺发育和泌乳过程中miRNA表达的时空特异性, 综述了个别miRNA对乳腺发育和泌乳的调节作用, 旨在为乳腺miRNA的研究提供指导, 为利用miRNA促进乳腺健康发育和调控高质高效产乳提供理论基础和研究思路。

关键词: miRNA, 乳腺发育, 泌乳

Abstract: MicroRNAs (miRNAs) are non-coding RNAs that play important roles in post transcriptional regulation. They are involved in the regulation of mammary gland development and lactation. In this paper, we summarized the expression pattern of miRNAs which varied with tissues and lactation stages, and the functions of several miRNAs are also briefly reviewed. The objective of this work is to give reference for further study on miRNAs in mammary gland, and to provide theoretical basis and ideas for the use of miRNAs in improving healthy development of mammary gland and regulating the efficiency of lactation and the quality of milk.

Key words: miRNA, mammary gland development, lactation